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Primary Hyperthyroidism

MedGen UID:
811409
•Concept ID:
C3714618
•
Disease or Syndrome
Synonym: Hyperthyroidism, Primary

Definition

Overproduction of thyroid hormone due to a disorder originating within the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Hyperthyroidism

Professional guidelines

PubMed

Efficacy Of Different Dosage Regimens Of Carbimazole In The Treatment Of Primary Hyperthyroidism.
Usman R, Ismail S, Tahir R, Jamil M
J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):244-247. PMID: 34137538
Diagnosis and treatment of TSH-secreting adenomas: review of a longtime experience in a reference center.
Nazato DM, Abucham J
J Endocrinol Invest 2018 Apr;41(4):447-454. Epub 2017 Oct 11 doi: 10.1007/s40618-017-0770-3. PMID: 29022276
Primary hyperthyroidism--diagnosis and treatment. Indications and contraindications for radioiodine therapy.
Gurgul E, Sowinski J
Nucl Med Rev Cent East Eur 2011;14(1):29-32. PMID: 21751169

Recent clinical studies

Etiology

Risk of perioperative thyroid storm in hyperthyroid patients: a systematic review.
de Mul N, Damstra J, Nieveen van Dijkum EJM, Fischli S, Kalkman CJ, Schellekens WM, Immink RV
Br J Anaesth 2021 Dec;127(6):879-889. Epub 2021 Aug 11 doi: 10.1016/j.bja.2021.06.043. PMID: 34389171
Assessment of Thyroid Function in Patients With Alkaptonuria.
Avadhanula S, Introne WJ, Auh S, Soldin SJ, Stolze B, Regier D, Ciccone C, Hannah-Shmouni F, Filie AC, Burman KD, Klubo-Gwiezdzinska J
JAMA Netw Open 2020 Mar 2;3(3):e201357. doi: 10.1001/jamanetworkopen.2020.1357. PMID: 32202644Free PMC Article
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
Renal lithiasis in patients with primary hyperparathyroidism. Evolution and treatment.
Valle Díaz de la Guardia F, Arrabal Martín M, Arrabal Polo MA, Quirosa Flores S, Miján Ortiz JL, Zuluaga Gómez A
Arch Esp Urol 2010 Jan-Feb;63(1):32-40. PMID: 20157217
Primary hyperparathyroidism, insulin resistance, and cardiovascular disease: a review.
Ybarra J, Doñate T, Jurado J, Pou JM
Nurs Clin North Am 2007 Mar;42(1):79-85, vii. doi: 10.1016/j.cnur.2006.11.010. PMID: 17270592

Diagnosis

Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
Primary hyperthyroidism--diagnosis and treatment. Indications and contraindications for radioiodine therapy.
Gurgul E, Sowinski J
Nucl Med Rev Cent East Eur 2011;14(1):29-32. PMID: 21751169
Renal lithiasis in patients with primary hyperparathyroidism. Evolution and treatment.
Valle Díaz de la Guardia F, Arrabal Martín M, Arrabal Polo MA, Quirosa Flores S, Miján Ortiz JL, Zuluaga Gómez A
Arch Esp Urol 2010 Jan-Feb;63(1):32-40. PMID: 20157217
Primary hyperparathyroidism, insulin resistance, and cardiovascular disease: a review.
Ybarra J, Doñate T, Jurado J, Pou JM
Nurs Clin North Am 2007 Mar;42(1):79-85, vii. doi: 10.1016/j.cnur.2006.11.010. PMID: 17270592
Central hyperthyroidism.
McDermott MT, Ridgway EC
Endocrinol Metab Clin North Am 1998 Mar;27(1):187-203. doi: 10.1016/s0889-8529(05)70306-6. PMID: 9534036

Therapy

Non-diabetic ketoacidosis secondary to primary hyperthyroidism: A case report.
Al-Mashdali AF, Gul M, Umer W, Omar A, Jones A
Medicine (Baltimore) 2022 Jun 10;101(23):e28253. doi: 10.1097/MD.0000000000028253. PMID: 35687767Free PMC Article
Risk of perioperative thyroid storm in hyperthyroid patients: a systematic review.
de Mul N, Damstra J, Nieveen van Dijkum EJM, Fischli S, Kalkman CJ, Schellekens WM, Immink RV
Br J Anaesth 2021 Dec;127(6):879-889. Epub 2021 Aug 11 doi: 10.1016/j.bja.2021.06.043. PMID: 34389171
Primary hyperthyroidism--diagnosis and treatment. Indications and contraindications for radioiodine therapy.
Gurgul E, Sowinski J
Nucl Med Rev Cent East Eur 2011;14(1):29-32. PMID: 21751169
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418670Free PMC Article
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2008 Mar 25;2008 PMID: 19450325Free PMC Article

Prognosis

Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418670Free PMC Article
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2008 Mar 25;2008 PMID: 19450325Free PMC Article
Parathyroid imaging: technique and role in the preoperative evaluation of primary hyperparathyroidism.
Johnson NA, Tublin ME, Ogilvie JB
AJR Am J Roentgenol 2007 Jun;188(6):1706-15. doi: 10.2214/AJR.06.0938. PMID: 17515397
Thyrotropin receptor autoantibodies (TSHRAbs): epitopes, origins and clinical significance.
Kohn LD, Harii N
Autoimmunity 2003 Sep-Nov;36(6-7):331-7. doi: 10.1080/08916930310001604199. PMID: 14669940

Clinical prediction guides

Thyroid Hormones Regulate the Thermoregulatory Mechanisms of the Body: Review.
Filfilan WM
Pak J Biol Sci 2023 Aug;26(9):453-457. doi: 10.3923/pjbs.2023.453.457. PMID: 38044694
Effects of thyroid hormones on thermogenesis and energy partitioning.
Iwen KA, Oelkrug R, Brabant G
J Mol Endocrinol 2018 Apr;60(3):R157-R170. Epub 2018 Feb 6 doi: 10.1530/JME-17-0319. PMID: 29434028
Primary hyperthyroidism--diagnosis and treatment. Indications and contraindications for radioiodine therapy.
Gurgul E, Sowinski J
Nucl Med Rev Cent East Eur 2011;14(1):29-32. PMID: 21751169
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418670Free PMC Article
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2008 Mar 25;2008 PMID: 19450325Free PMC Article

Recent systematic reviews

Risk of perioperative thyroid storm in hyperthyroid patients: a systematic review.
de Mul N, Damstra J, Nieveen van Dijkum EJM, Fischli S, Kalkman CJ, Schellekens WM, Immink RV
Br J Anaesth 2021 Dec;127(6):879-889. Epub 2021 Aug 11 doi: 10.1016/j.bja.2021.06.043. PMID: 34389171
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2010 Jul 19;2010 PMID: 21418670Free PMC Article
Hyperthyroidism (primary).
Nygaard B
BMJ Clin Evid 2008 Mar 25;2008 PMID: 19450325Free PMC Article

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