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Abnormal vena cava morphology

MedGen UID:: 1391621
•Concept ID:: C4476886
•: Anatomical Abnormality

Synonym:	Abnormality of the vena cava

HPO:	HP:0005345

Definition

An abnormality of the structure of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Abnormal vena cava morphology

Phenotypic abnormality
- Abnormality of the cardiovascular system
  - Abnormal cardiovascular system morphology
    - Abnormal vascular morphology
      - Abnormal blood vessel morphology
        Abnormal morphology of the great vessels
        Abnormal vena cava morphology
        Abnormal inferior vena cava morphology
        Enlarged Eustachian valve
        Inferior vena cava obstruction
        Interrupted inferior vena cava with azygous continuation
        Abnormal superior vena cava morphology
        Infra-aortic superior vena cava
        Obstruction of the superior vena cava
        Persistent left superior vena cava
        Absent right superior vena cava
        Bilateral superior vena cava

Professional guidelines

PubMed

Persistent Left Superior Vena Cava: Why is Prenatal Diagnosis Important?

Keleş A, Yılmaz O, Dağdeviren G, Çelik ÖY, Yücel A, Şahin D
Fetal Pediatr Pathol 2022 Aug;41(4):592-602. Epub 2021 Jun 9 doi: 10.1080/15513815.2021.1933662. PMID: 34106033

Caval Thrombus Management: The Data, Where We Are, and How It Is Done.

Harrison B, Hao F, Koney N, McWilliams J, Moriarty JM
Tech Vasc Interv Radiol 2018 Jun;21(2):65-77. Epub 2018 Mar 9 doi: 10.1053/j.tvir.2018.03.002. PMID: 29784124

May-Thurner syndrome: diagnosis and management.

Brazeau NF, Harvey HB, Pinto EG, Deipolyi A, Hesketh RL, Oklu R
Vasa 2013 Mar;42(2):96-105. doi: 10.1024/0301-1526/a000252. PMID: 23485836

See all (65)

Recent clinical studies

Etiology

Inferior vena cava thrombosis-rope ladder sign.

Meyer S, Poryo M
Wien Med Wochenschr 2023 May;173(7-8):159-160. Epub 2021 Oct 6 doi: 10.1007/s10354-021-00886-y. PMID: 34613517 Free PMC Article

Anomalies of Inferior Vena Cava: Implications and Considerations in Retroperitoneal Surgical Procedures.

Nigro B, Ayarragaray JEF
Ann Vasc Surg 2022 Feb;79:372-379. Epub 2021 Oct 10 doi: 10.1016/j.avsg.2021.07.029. PMID: 34644626

Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.

Syngelaki A, Hammami A, Bower S, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2019 Oct;54(4):468-476. doi: 10.1002/uog.20844. PMID: 31408229

Persistent Left Superior Vena Cava in Fetuses: An Autopsy Series.

Ramakrishnan D, Chidambarathanu S, Murli L, Micheal J, Jagadeesh S, Suresh I, Seshadri S
Fetal Pediatr Pathol 2017 Aug;36(4):304-310. Epub 2017 Jun 1 doi: 10.1080/15513815.2017.1324546. PMID: 28569558

Inferior vena cava filter-associated abnormalities: MDCT findings.

Rao B, Duran C, Steigner ML, Rybicki FJ
AJR Am J Roentgenol 2012 Jun;198(6):W605-10. doi: 10.2214/AJR.11.7664. PMID: 22623578

See all (1026)

Diagnosis

Outcomes following prenatal diagnosis of isolated persistent left superior vena cava.

Durand I, Hazelzet T, Gillibert A, Parrod C, David N, El Youssef F, Brehin AC, Barre E
Arch Cardiovasc Dis 2022 Jun-Jul;115(6-7):335-347. Epub 2022 May 14 doi: 10.1016/j.acvd.2022.03.005. PMID: 35660361

Persistent Left Superior Vena Cava: Why is Prenatal Diagnosis Important?

Keleş A, Yılmaz O, Dağdeviren G, Çelik ÖY, Yücel A, Şahin D
Fetal Pediatr Pathol 2022 Aug;41(4):592-602. Epub 2021 Jun 9 doi: 10.1080/15513815.2021.1933662. PMID: 34106033

Persistent Left Superior Vena Cava in Fetuses: An Autopsy Series.

Double Inferior Vena Cava and its Implications During Endovascular and Surgical Interventions: A Word of Caution.

Shammas NW, Rachwan RJ, Daher G, Bou Dargham B
J Invasive Cardiol 2017 Feb;29(2):51-53. PMID: 28145872

Comprehensive Imaging Review of the Superior Vena Cava.

Sonavane SK, Milner DM, Singh SP, Abdel Aal AK, Shahir KS, Chaturvedi A
Radiographics 2015 Nov-Dec;35(7):1873-92. Epub 2015 Oct 9 doi: 10.1148/rg.2015150056. PMID: 26452112

See all (2184)

Therapy

Anomalies of Inferior Vena Cava: Implications and Considerations in Retroperitoneal Surgical Procedures.

Nigro B, Ayarragaray JEF
Ann Vasc Surg 2022 Feb;79:372-379. Epub 2021 Oct 10 doi: 10.1016/j.avsg.2021.07.029. PMID: 34644626

Suprarenal Inferior Vena Cava Filter Placement and Retrieval: Safety Analysis.

Baheti A, Sheeran D, Patrie J, Sabri SS, Angle JF, Wilkins LR
J Vasc Interv Radiol 2020 Feb;31(2):231-235. Epub 2019 Dec 26 doi: 10.1016/j.jvir.2019.08.012. PMID: 31883935

Vascular Behçet's syndrome: an update.

Emmi G, Bettiol A, Silvestri E, Di Scala G, Becatti M, Fiorillo C, Prisco D
Intern Emerg Med 2019 Aug;14(5):645-652. Epub 2018 Nov 29 doi: 10.1007/s11739-018-1991-y. PMID: 30499073

Caval Thrombus Management: The Data, Where We Are, and How It Is Done.

Harrison B, Hao F, Koney N, McWilliams J, Moriarty JM
Tech Vasc Interv Radiol 2018 Jun;21(2):65-77. Epub 2018 Mar 9 doi: 10.1053/j.tvir.2018.03.002. PMID: 29784124

Inferior vena cava filter-associated abnormalities: MDCT findings.

Rao B, Duran C, Steigner ML, Rybicki FJ
AJR Am J Roentgenol 2012 Jun;198(6):W605-10. doi: 10.2214/AJR.11.7664. PMID: 22623578

See all (531)

Prognosis

Duplication of the inferior vena cava: a case series.

Li WR, Feng H, Jin L, Chen XM, Zhang ZW
J Int Med Res 2022 May;50(5):3000605221100771. doi: 10.1177/03000605221100771. PMID: 35607249 Free PMC Article

Anomalies of Inferior Vena Cava: Implications and Considerations in Retroperitoneal Surgical Procedures.

Nigro B, Ayarragaray JEF
Ann Vasc Surg 2022 Feb;79:372-379. Epub 2021 Oct 10 doi: 10.1016/j.avsg.2021.07.029. PMID: 34644626

Left superior vena cava: cross-sectional imaging overview.

Batouty NM, Sobh DM, Gadelhak B, Sobh HM, Mahmoud W, Tawfik AM
Radiol Med 2020 Mar;125(3):237-246. Epub 2019 Dec 10 doi: 10.1007/s11547-019-01114-9. PMID: 31823296

Double Inferior Vena Cava and its Implications During Endovascular and Surgical Interventions: A Word of Caution.

Shammas NW, Rachwan RJ, Daher G, Bou Dargham B
J Invasive Cardiol 2017 Feb;29(2):51-53. PMID: 28145872

Left-sided and duplicate inferior vena cava: a case series and review.

Ang WC, Doyle T, Stringer MD
Clin Anat 2013 Nov;26(8):990-1001. Epub 2012 May 10 doi: 10.1002/ca.22090. PMID: 22576868

See all (872)

Clinical prediction guides

Clinical significance of prenatally diagnosed persistent left superior vena cava.

Esin D, Aslan Çetin B, Şenol G, Selçuki NFT, Gedik Özköse Z, Acar Z, Yüksel MA
J Gynecol Obstet Hum Reprod 2022 Apr;51(4):102332. Epub 2022 Feb 2 doi: 10.1016/j.jogoh.2022.102332. PMID: 35123124

Anomalies of Inferior Vena Cava: Implications and Considerations in Retroperitoneal Surgical Procedures.

Nigro B, Ayarragaray JEF
Ann Vasc Surg 2022 Feb;79:372-379. Epub 2021 Oct 10 doi: 10.1016/j.avsg.2021.07.029. PMID: 34644626

Suprarenal Inferior Vena Cava Filter Placement and Retrieval: Safety Analysis.

Baheti A, Sheeran D, Patrie J, Sabri SS, Angle JF, Wilkins LR
J Vasc Interv Radiol 2020 Feb;31(2):231-235. Epub 2019 Dec 26 doi: 10.1016/j.jvir.2019.08.012. PMID: 31883935

Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.

Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326

Inferior Vena Cava Atresia: Characterisation of Risk Factors, Treatment, and Outcomes.

Mabud TS, Sailer AM, Swee JKY, Tamboli M, Arendt VA, Jeon GS, An X, Cohn DM, Kuo WT, Hofmann LV
Cardiovasc Intervent Radiol 2020 Jan;43(1):37-45. Epub 2019 Oct 24 doi: 10.1007/s00270-019-02353-z. PMID: 31650242

See all (489)

Recent systematic reviews

Systematic review of electrophysiology procedures in patients with obstruction of the inferior vena cava.

Al-Sinan A, Chan KH, Young GD, Martin A, Sepahpour A, Sy RW
J Cardiovasc Electrophysiol 2022 Jun;33(6):1300-1311. Epub 2022 Apr 30 doi: 10.1111/jce.15505. PMID: 35441755 Free PMC Article

Duplication and transposition of inferior vena cava: A meta-analysis of prevalence.

Hostiuc S, Minoiu C, Negoi I, Rusu MC, Hostiuc M
J Vasc Surg Venous Lymphat Disord 2019 Sep;7(5):742-755. Epub 2019 May 5 doi: 10.1016/j.jvsv.2019.01.063. PMID: 31068277

Dilated cerebral venous system observed in growth-restricted fetuses.

Baron J, Mastrolia SA, Shelef I, Tirosh D, Daniel-Spiegel E, Hershkovitz R
J Matern Fetal Neonatal Med 2018 May;31(10):1369-1372. Epub 2017 Apr 20 doi: 10.1080/14767058.2017.1315097. PMID: 28372477

Left-sided and duplicate inferior vena cava: a case series and review.

Ang WC, Doyle T, Stringer MD
Clin Anat 2013 Nov;26(8):990-1001. Epub 2012 May 10 doi: 10.1002/ca.22090. PMID: 22576868

Double inferior vena cava with interiliac vein: a case report and literature review.

Chen H, Emura S, Nagasaki S, Kubo KY
Okajimas Folia Anat Jpn 2012 Feb;88(4):147-51. doi: 10.2535/ofaj.88.147. PMID: 22645906

See all (8)

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Abnormal vena cava morphology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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