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Advanced Head and Neck Carcinoma

MedGen UID:
1391724
•Concept ID:
C4329280
•
Neoplastic Process

Definition

A head and neck carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Response Rate of Cisplatin Plus Docetaxel as Primary Treatment in Locally Advanced Head and Neck Carcinoma (Squamous Cell Types).
Nouman M, Haider G, Bukhari N, Yousuf A, Nouman R, Shaikh MR, Hussain S, Pavan B, Rahool R, Memon P, Zahoor S, Mehar K, Sami A
Asian Pac J Cancer Prev 2020 Mar 1;21(3):825-830. doi: 10.31557/APJCP.2020.21.3.825. PMID: 32212813Free PMC Article
Elderly Patients with Advanced Head and Neck Carcinoma: Does Aggressive Treatment Result in Better Outcomes?
Jang IJH, Skanthakumar T, Tan HK, Tan NC, Soo KC, Iyer NG
Otolaryngol Head Neck Surg 2019 Apr;160(4):642-650. Epub 2018 Dec 18 doi: 10.1177/0194599818815065. PMID: 30558490
BOMM regimen for the treatment of advanced head and neck carcinoma.
Kohno N, Inuyama Y, Sakurai S, Ohnuma T
Cancer Invest 1991;9(5):485-9. doi: 10.3109/07357909109018946. PMID: 1718577

Recent clinical studies

Etiology

Confounding factors in the assessment of oral mucositis in head and neck cancer.
Lorini L, Perri F, Vecchio S, Belgioia L, Vinches M, Brana I, Elad S, Bossi P
Support Care Cancer 2022 Oct;30(10):8455-8463. Epub 2022 May 31 doi: 10.1007/s00520-022-07128-w. PMID: 35639187Free PMC Article
Cetuximab pharmacokinetic/pharmacodynamics relationships in advanced head and neck carcinoma patients.
Le Louedec F, Alix-Panabières C, Lafont T, Allal BC, Garrel R, Digue L, Guigay J, Cupissol D, Delord JP, Lallemant B, Alfonsi M, Aubry K, Mazel M, Becher F, Perriard F, Chatelut E, Thomas F
Br J Clin Pharmacol 2019 Jun;85(6):1357-1366. Epub 2019 Apr 13 doi: 10.1111/bcp.13907. PMID: 30811063Free PMC Article
Elderly Patients with Advanced Head and Neck Carcinoma: Does Aggressive Treatment Result in Better Outcomes?
Jang IJH, Skanthakumar T, Tan HK, Tan NC, Soo KC, Iyer NG
Otolaryngol Head Neck Surg 2019 Apr;160(4):642-650. Epub 2018 Dec 18 doi: 10.1177/0194599818815065. PMID: 30558490
Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial.
Bourhis J, Sire C, Graff P, Grégoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, Tao YG, Blanchard P, Aupérin A
Lancet Oncol 2012 Feb;13(2):145-53. Epub 2012 Jan 18 doi: 10.1016/S1470-2045(11)70346-1. PMID: 22261362
Pretreatment probability model for predicting outcome after intraarterial chemoradiation for advanced head and neck carcinoma.
van den Broek GB, Rasch CR, Pameijer FA, Peter E, van den Brekel MW, Tan IB, Schornagel JH, de Bois JA, Zijp LJ, Balm AJ
Cancer 2004 Oct 15;101(8):1809-17. doi: 10.1002/cncr.20556. PMID: 15386309

Diagnosis

Relevance of the time interval between surgery and adjuvant radio (chemo) therapy in HPV-negative and advanced head and neck carcinoma of unknown primary (CUP).
Balk M, Rupp R, Mantsopoulos K, Allner M, Grundtner P, Mueller SK, Traxdorf M, Eckstein M, Speer S, Semrau S, Fietkau R, Iro H, Hecht M, Gostian AO
BMC Cancer 2021 Nov 18;21(1):1236. doi: 10.1186/s12885-021-08885-3. PMID: 34794411Free PMC Article
Cetuximab pharmacokinetic/pharmacodynamics relationships in advanced head and neck carcinoma patients.
Le Louedec F, Alix-Panabières C, Lafont T, Allal BC, Garrel R, Digue L, Guigay J, Cupissol D, Delord JP, Lallemant B, Alfonsi M, Aubry K, Mazel M, Becher F, Perriard F, Chatelut E, Thomas F
Br J Clin Pharmacol 2019 Jun;85(6):1357-1366. Epub 2019 Apr 13 doi: 10.1111/bcp.13907. PMID: 30811063Free PMC Article
Neoadjuvant radiotherapy of head and neck carcinoma: an obstacle for plastic reconstruction?
Riml S, Böhler F, Larcher L, de Vries A, Elsässer W, Kompatscher P
Wien Klin Wochenschr 2012 Sep;124(17-18):599-604. Epub 2012 Aug 1 doi: 10.1007/s00508-012-0214-1. PMID: 22850812
Evaluation of patients with head and neck cancer by means of 99mTc-glucarate.
Gambini JP, Nuñez M, Cabral P, Lafferranderie M, Noble J, Corchs E, D'Albora R, Savio E, Delgado L, Alonso O
J Nucl Med Technol 2009 Dec;37(4):229-32. doi: 10.2967/jnmt.109.062927. PMID: 19949020
Induction paclitaxel and carboplatin for patients with head and neck carcinoma. Analysis of 62 patients treated between 1994 an 1999.
Dunphy FR, Dunleavy TL, Harrison BR, Trinkaus KM, Kim HJ, Stack BC Jr, Needles B, Boyd JH
Cancer 2001 Mar 1;91(5):940-8. PMID: 11251945

Therapy

Long-Term Update of NRG/RTOG 0522: A Randomized Phase 3 Trial of Concurrent Radiation and Cisplatin With or Without Cetuximab in Locoregionally Advanced Head and Neck Cancer.
Caudell JJ, Torres-Saavedra PA, Rosenthal DI, Axelrod RS, Nguyen-Tan PF, Sherman EJ, Weber RS, Galvin JM, El-Naggar AK, Konski AA, Echevarria MI, Dunlap NE, Shenouda G, Singh AK, Beitler JJ, Garsa A, Bonner JA, Garden AS, Algan O, Harris J, Le QT
Int J Radiat Oncol Biol Phys 2023 Jul 1;116(3):533-543. Epub 2022 Dec 19 doi: 10.1016/j.ijrobp.2022.12.015. PMID: 36549347Free PMC Article
ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy.
Guberina M, Sak A, Pöttgen C, Tinhofer-Keilholz I, Budach V, Balermpas P, Von der Grün J, Rödel CM, Gkika E, Grosu AL, Abdollahi A, Debus J, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, De-Colle C, Welz S, Linge A, Lohaus F, Baretton G, Gauler T, Baumann M, Krause M, Schuler M, Bankfalvi A, Höing B, Lang S, Stuschke M
Pharmacogenomics J 2021 Feb;21(1):37-46. Epub 2020 Jun 16 doi: 10.1038/s41397-020-0174-1. PMID: 32546699Free PMC Article
Cetuximab pharmacokinetic/pharmacodynamics relationships in advanced head and neck carcinoma patients.
Le Louedec F, Alix-Panabières C, Lafont T, Allal BC, Garrel R, Digue L, Guigay J, Cupissol D, Delord JP, Lallemant B, Alfonsi M, Aubry K, Mazel M, Becher F, Perriard F, Chatelut E, Thomas F
Br J Clin Pharmacol 2019 Jun;85(6):1357-1366. Epub 2019 Apr 13 doi: 10.1111/bcp.13907. PMID: 30811063Free PMC Article
Accelerated hypofractionation (OCTA SHOT): Palliative radiation schedule in advanced head and neck carcinoma.
Jakhar SL, Purohit R, Solanki A, Murali P, Kothari T, Sharma N, Kumar HS
J Cancer Res Ther 2017 Oct-Dec;13(6):943-946. doi: 10.4103/jcrt.JCRT_767_16. PMID: 29237955
Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial.
Bourhis J, Sire C, Graff P, Grégoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, Tao YG, Blanchard P, Aupérin A
Lancet Oncol 2012 Feb;13(2):145-53. Epub 2012 Jan 18 doi: 10.1016/S1470-2045(11)70346-1. PMID: 22261362

Prognosis

Relevance of the time interval between surgery and adjuvant radio (chemo) therapy in HPV-negative and advanced head and neck carcinoma of unknown primary (CUP).
Balk M, Rupp R, Mantsopoulos K, Allner M, Grundtner P, Mueller SK, Traxdorf M, Eckstein M, Speer S, Semrau S, Fietkau R, Iro H, Hecht M, Gostian AO
BMC Cancer 2021 Nov 18;21(1):1236. doi: 10.1186/s12885-021-08885-3. PMID: 34794411Free PMC Article
ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy.
Guberina M, Sak A, Pöttgen C, Tinhofer-Keilholz I, Budach V, Balermpas P, Von der Grün J, Rödel CM, Gkika E, Grosu AL, Abdollahi A, Debus J, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, De-Colle C, Welz S, Linge A, Lohaus F, Baretton G, Gauler T, Baumann M, Krause M, Schuler M, Bankfalvi A, Höing B, Lang S, Stuschke M
Pharmacogenomics J 2021 Feb;21(1):37-46. Epub 2020 Jun 16 doi: 10.1038/s41397-020-0174-1. PMID: 32546699Free PMC Article
Elderly Patients with Advanced Head and Neck Carcinoma: Does Aggressive Treatment Result in Better Outcomes?
Jang IJH, Skanthakumar T, Tan HK, Tan NC, Soo KC, Iyer NG
Otolaryngol Head Neck Surg 2019 Apr;160(4):642-650. Epub 2018 Dec 18 doi: 10.1177/0194599818815065. PMID: 30558490
Neoadjuvant radiotherapy of head and neck carcinoma: an obstacle for plastic reconstruction?
Riml S, Böhler F, Larcher L, de Vries A, Elsässer W, Kompatscher P
Wien Klin Wochenschr 2012 Sep;124(17-18):599-604. Epub 2012 Aug 1 doi: 10.1007/s00508-012-0214-1. PMID: 22850812
Pretreatment probability model for predicting outcome after intraarterial chemoradiation for advanced head and neck carcinoma.
van den Broek GB, Rasch CR, Pameijer FA, Peter E, van den Brekel MW, Tan IB, Schornagel JH, de Bois JA, Zijp LJ, Balm AJ
Cancer 2004 Oct 15;101(8):1809-17. doi: 10.1002/cncr.20556. PMID: 15386309

Clinical prediction guides

ERCC2 gene single-nucleotide polymorphism as a prognostic factor for locally advanced head and neck carcinomas after definitive cisplatin-based radiochemotherapy.
Guberina M, Sak A, Pöttgen C, Tinhofer-Keilholz I, Budach V, Balermpas P, Von der Grün J, Rödel CM, Gkika E, Grosu AL, Abdollahi A, Debus J, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, De-Colle C, Welz S, Linge A, Lohaus F, Baretton G, Gauler T, Baumann M, Krause M, Schuler M, Bankfalvi A, Höing B, Lang S, Stuschke M
Pharmacogenomics J 2021 Feb;21(1):37-46. Epub 2020 Jun 16 doi: 10.1038/s41397-020-0174-1. PMID: 32546699Free PMC Article
Cetuximab pharmacokinetic/pharmacodynamics relationships in advanced head and neck carcinoma patients.
Le Louedec F, Alix-Panabières C, Lafont T, Allal BC, Garrel R, Digue L, Guigay J, Cupissol D, Delord JP, Lallemant B, Alfonsi M, Aubry K, Mazel M, Becher F, Perriard F, Chatelut E, Thomas F
Br J Clin Pharmacol 2019 Jun;85(6):1357-1366. Epub 2019 Apr 13 doi: 10.1111/bcp.13907. PMID: 30811063Free PMC Article
Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma - a feasibility study.
Verduijn GM, de Wee EM, Rijnen Z, Togni P, Hardillo JAU, Ten Hove I, Franckena M, van Rhoon GC, Paulides MM
Int J Hyperthermia 2018 Nov;34(7):994-1001. Epub 2018 May 11 doi: 10.1080/02656736.2018.1454610. PMID: 29747544
A Nomogram to predict parotid gland overdose in head and neck IMRT.
Castelli J, Simon A, Rigaud B, Lafond C, Chajon E, Ospina JD, Haigron P, Laguerre B, Loubière AR, Benezery K, de Crevoisier R
Radiat Oncol 2016 Jun 8;11:79. doi: 10.1186/s13014-016-0650-6. PMID: 27278960Free PMC Article
Pretreatment probability model for predicting outcome after intraarterial chemoradiation for advanced head and neck carcinoma.
van den Broek GB, Rasch CR, Pameijer FA, Peter E, van den Brekel MW, Tan IB, Schornagel JH, de Bois JA, Zijp LJ, Balm AJ
Cancer 2004 Oct 15;101(8):1809-17. doi: 10.1002/cncr.20556. PMID: 15386309

Recent systematic reviews

Sacrifice and extracranial reconstruction of the common or internal carotid artery in advanced head and neck carcinoma: Review and meta-analysis.
Bäck LJJ, Aro K, Tapiovaara L, Vikatmaa P, de Bree R, Fernández-Álvarez V, Kowalski LP, Nixon IJ, Rinaldo A, Rodrigo JP, Robbins KT, Silver CE, Snyderman CH, Suárez C, Takes RP, Ferlito A
Head Neck 2018 Jun;40(6):1305-1320. Epub 2018 Feb 5 doi: 10.1002/hed.25093. PMID: 29405536

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