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Advanced Oropharyngeal Carcinoma

MedGen UID:
1729598
•Concept ID:
C5418792
•
Neoplastic Process

Definition

Oropharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Oropharyngeal Carcinoma

Professional guidelines

PubMed

A real-world comparison of cisplatin vs cetuximab used concurrently with radiation in the treatment of locally advanced oropharyngeal carcinoma.
Fung AS, Afzal AR, Banerjee R, Debenham B, Hao D
Head Neck 2021 Jan;43(1):153-163. Epub 2020 Sep 19 doi: 10.1002/hed.26469. PMID: 32949087
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011

Recent clinical studies

Etiology

Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates.
Haist M, Kaufmann J, Kur IM, Zimmer S, Grabbe S, Schmidberger H, Weigert A, Mayer A
Front Immunol 2023;14:1070203. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1070203. PMID: 37187729Free PMC Article
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011
Transoral robotic surgery for advanced oropharyngeal carcinoma.
Weinstein GS, O'Malley BW Jr, Cohen MA, Quon H
Arch Otolaryngol Head Neck Surg 2010 Nov;136(11):1079-85. doi: 10.1001/archoto.2010.191. PMID: 21079160
Quality of life in advanced oropharyngeal carcinoma after chemoradiation versus surgery and radiation.
Mowry SE, Ho A, Lotempio MM, Sadeghi A, Blackwell KE, Wang MB
Laryngoscope 2006 Sep;116(9):1589-93. doi: 10.1097/01.mlg.0000233244.18901.44. PMID: 16954985

Diagnosis

Predicting two-year longitudinal MD Anderson Dysphagia Inventory outcomes after intensity modulated radiotherapy for locoregionally advanced oropharyngeal carcinoma.
Goepfert RP, Lewin JS, Barrow MP, Fuller CD, Lai SY, Song J, Hobbs BP, Gunn GB, Beadle BM, Rosenthal DI, Garden AS, Kies MS, Papadimitrakopoulou VA, Schwartz DL, Hutcheson KA
Laryngoscope 2017 Apr;127(4):842-848. Epub 2016 Jul 21 doi: 10.1002/lary.26153. PMID: 27440393Free PMC Article
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century.
Garden AS, Kies MS, Morrison WH, Weber RS, Frank SJ, Glisson BS, Gunn GB, Beadle BM, Ang KK, Rosenthal DI, Sturgis EM
Radiat Oncol 2013 Jan 29;8:21. doi: 10.1186/1748-717X-8-21. PMID: 23360540Free PMC Article
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma.
Lybak S, Liavaag PG, Monge OR, Olofsson J
Eur Arch Otorhinolaryngol 2011 Mar;268(3):449-56. Epub 2010 Aug 28 doi: 10.1007/s00405-010-1344-6. PMID: 20803151Free PMC Article
Transoral robotic surgery for advanced oropharyngeal carcinoma.
Weinstein GS, O'Malley BW Jr, Cohen MA, Quon H
Arch Otolaryngol Head Neck Surg 2010 Nov;136(11):1079-85. doi: 10.1001/archoto.2010.191. PMID: 21079160

Therapy

Predicting two-year longitudinal MD Anderson Dysphagia Inventory outcomes after intensity modulated radiotherapy for locoregionally advanced oropharyngeal carcinoma.
Goepfert RP, Lewin JS, Barrow MP, Fuller CD, Lai SY, Song J, Hobbs BP, Gunn GB, Beadle BM, Rosenthal DI, Garden AS, Kies MS, Papadimitrakopoulou VA, Schwartz DL, Hutcheson KA
Laryngoscope 2017 Apr;127(4):842-848. Epub 2016 Jul 21 doi: 10.1002/lary.26153. PMID: 27440393Free PMC Article
Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century.
Garden AS, Kies MS, Morrison WH, Weber RS, Frank SJ, Glisson BS, Gunn GB, Beadle BM, Ang KK, Rosenthal DI, Sturgis EM
Radiat Oncol 2013 Jan 29;8:21. doi: 10.1186/1748-717X-8-21. PMID: 23360540Free PMC Article
Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors.
Krstevska V, Stojkovski I, Zafirova-Ivanovska B
Radiat Oncol 2012 May 28;7:78. doi: 10.1186/1748-717X-7-78. PMID: 22640662Free PMC Article
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011
Combined-modality therapy for locoregionally advanced head and neck cancer.
Cmelak AJ, Murphy BA, Day T
Oncology (Williston Park) 1999 Oct;13(10 Suppl 5):83-91. PMID: 10550831

Prognosis

Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates.
Haist M, Kaufmann J, Kur IM, Zimmer S, Grabbe S, Schmidberger H, Weigert A, Mayer A
Front Immunol 2023;14:1070203. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1070203. PMID: 37187729Free PMC Article
Prognosis of HPV-Positive and -Negative Oropharyngeal Cancers Depends on the Treatment Modality.
Horáková Z, Slavik M, Veselý K, Budíková M, Kostřica R, Binková H
Klin Onkol 2019 Spring;32(3):187-196. PMID: 31216850
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011
Transoral robotic surgery for advanced oropharyngeal carcinoma.
Weinstein GS, O'Malley BW Jr, Cohen MA, Quon H
Arch Otolaryngol Head Neck Surg 2010 Nov;136(11):1079-85. doi: 10.1001/archoto.2010.191. PMID: 21079160

Clinical prediction guides

Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates.
Haist M, Kaufmann J, Kur IM, Zimmer S, Grabbe S, Schmidberger H, Weigert A, Mayer A
Front Immunol 2023;14:1070203. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1070203. PMID: 37187729Free PMC Article
A real-world comparison of cisplatin vs cetuximab used concurrently with radiation in the treatment of locally advanced oropharyngeal carcinoma.
Fung AS, Afzal AR, Banerjee R, Debenham B, Hao D
Head Neck 2021 Jan;43(1):153-163. Epub 2020 Sep 19 doi: 10.1002/hed.26469. PMID: 32949087
Predicting two-year longitudinal MD Anderson Dysphagia Inventory outcomes after intensity modulated radiotherapy for locoregionally advanced oropharyngeal carcinoma.
Goepfert RP, Lewin JS, Barrow MP, Fuller CD, Lai SY, Song J, Hobbs BP, Gunn GB, Beadle BM, Rosenthal DI, Garden AS, Kies MS, Papadimitrakopoulou VA, Schwartz DL, Hutcheson KA
Laryngoscope 2017 Apr;127(4):842-848. Epub 2016 Jul 21 doi: 10.1002/lary.26153. PMID: 27440393Free PMC Article
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Advanced oropharyngeal carcinoma treated with surgery and radiotherapy: oncologic outcome and functional assessment.
Denittis AS, Machtay M, Rosenthal DI, Sanfilippo NJ, Lee JH, Goldfeder S, Chalian AA, Weinstein GS, Weber RS
Am J Otolaryngol 2001 Sep-Oct;22(5):329-35. doi: 10.1053/ajot.2001.26492. PMID: 11562884

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