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Metastatic Malignant Neoplasm in the Liver

MedGen UID:
141667
Concept ID:
C0494165
Neoplastic Process
Synonyms: Cancer metastatic to liver; Hepatic metastasis; Liver Metastases; Liver Metastasis; Liver secondaries; Liver secondary cancer; Metastasis to liver; Metastatic malignant neoplasm of liver; Metastatic malignant neoplasm to liver; Metastatic Malignant Neoplasm to the Liver; Metastatic Neoplasm to the Liver; Metastatic Tumor to the Liver; Secondary malignancy of liver; Secondary malignant neoplasm of liver
SNOMED CT: Secondary malignant neoplasm of liver (94381002); Metastatic malignant neoplasm to liver (94381002); Cancer metastatic to liver (94381002); Metastatic malignant neoplasm of liver (94381002); Liver secondary cancer (94381002); Metastasis to liver (94381002); Liver secondaries (94381002); Secondary malignancy of liver (94381002); Hepatic metastasis (94381002)

Definition

A malignant neoplasm that has spread to the liver from another (primary) anatomic site. Representative examples include carcinomas, lymphomas, melanomas, or sarcomas. [from NCI]

Professional guidelines

PubMed

Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Bonney GK, Chew CA, Lodge P, Hubbard J, Halazun KJ, Trunecka P, Muiesan P, Mirza DF, Isaac J, Laing RW, Iyer SG, Chee CE, Yong WP, Muthiah MD, Panaro F, Sanabria J, Grothey A, Moodley K, Chau I, Chan ACY, Wang CC, Menon K, Sapisochin G, Hagness M, Dueland S, Line PD, Adam R
Lancet Gastroenterol Hepatol 2021 Nov;6(11):933-946. Epub 2021 Sep 8 doi: 10.1016/S2468-1253(21)00219-3. PMID: 34506756
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Lopez-Lopez V, Linecker M, Caballero-Llanes A, Reese T, Oldhafer KJ, Hernandez-Alejandro R, Tun-Abraham M, Li J, Fard-Aghaie M, Petrowsky H, Brusadin R, Lopez-Conesa A, Ratti F, Aldrighetti L, Ramouz A, Mehrabi A, Autran Machado M, Ardiles V, De Santibañes E, Marichez A, Adam R, Truant S, Pruvot FR, Olthof PB, Van Gulick TM, Montalti R, Troisi RI, Kron P, Lodge P, Kambakamba P, Hoti E, Martinez-Caceres C, de la Peña-Moral J, Clavien PA, Robles-Campos R
Ann Surg 2024 Feb 1;279(2):306-313. Epub 2023 Jul 24 doi: 10.1097/SLA.0000000000006024. PMID: 37487004
Kurzawski M, Szeląg-Pieniek S, Łapczuk-Romańska J, Wrzesiński M, Oswald S, Droździk M
Pharmacol Rep 2022 Feb;74(1):204-215. Epub 2021 Nov 6 doi: 10.1007/s43440-021-00337-w. PMID: 34741761Free PMC Article
Strathearn LS, Stepanov AI, Font-Burgada J
Nutrients 2020 Mar 27;12(4) doi: 10.3390/nu12040933. PMID: 32230953Free PMC Article
Thirunavukarasu P, Aloia TA
Surg Clin North Am 2016 Apr;96(2):197-205. Epub 2016 Feb 16 doi: 10.1016/j.suc.2015.11.001. PMID: 27017859
Groen KA
Semin Oncol Nurs 1999 Feb;15(1):48-57. doi: 10.1016/s0749-2081(99)80039-4. PMID: 10074657

Diagnosis

Boulter L, Bullock E, Mabruk Z, Brunton VG
Br J Cancer 2021 Jan;124(1):27-36. Epub 2020 Nov 26 doi: 10.1038/s41416-020-01172-1. PMID: 33239677Free PMC Article
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Pittman ME, Yantiss RK
Surg Pathol Clin 2018 Jun;11(2):453-466. Epub 2018 Mar 26 doi: 10.1016/j.path.2018.02.012. PMID: 29751885
Thyagarajan MS, Sharif K
Indian J Pediatr 2016 Nov;83(11):1291-1302. Epub 2016 Oct 25 doi: 10.1007/s12098-016-2240-x. PMID: 27783314
Donnelly LF, Bisset GS 3rd
Radiol Clin North Am 1998 Mar;36(2):413-27. doi: 10.1016/s0033-8389(05)70032-4. PMID: 9520992

Therapy

Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A
Nat Commun 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. PMID: 37741832Free PMC Article
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Clift AK, Frilling A
Curr Oncol Rep 2021 Mar 15;23(4):44. doi: 10.1007/s11912-021-01030-0. PMID: 33721122
Puijk RS, Ruarus AH, Vroomen LGPH, van Tilborg AAJM, Scheffer HJ, Nielsen K, de Jong MC, de Vries JJJ, Zonderhuis BM, Eker HH, Kazemier G, Verheul H, van der Meijs BB, van Dam L, Sorgedrager N, Coupé VMH, van den Tol PMP, Meijerink MR; COLLISION Trial Group
BMC Cancer 2018 Aug 15;18(1):821. doi: 10.1186/s12885-018-4716-8. PMID: 30111304Free PMC Article
Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733Free PMC Article

Prognosis

Lopez-Lopez V, Linecker M, Caballero-Llanes A, Reese T, Oldhafer KJ, Hernandez-Alejandro R, Tun-Abraham M, Li J, Fard-Aghaie M, Petrowsky H, Brusadin R, Lopez-Conesa A, Ratti F, Aldrighetti L, Ramouz A, Mehrabi A, Autran Machado M, Ardiles V, De Santibañes E, Marichez A, Adam R, Truant S, Pruvot FR, Olthof PB, Van Gulick TM, Montalti R, Troisi RI, Kron P, Lodge P, Kambakamba P, Hoti E, Martinez-Caceres C, de la Peña-Moral J, Clavien PA, Robles-Campos R
Ann Surg 2024 Feb 1;279(2):306-313. Epub 2023 Jul 24 doi: 10.1097/SLA.0000000000006024. PMID: 37487004
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Clift AK, Frilling A
World J Gastroenterol 2018 May 28;24(20):2152-2162. doi: 10.3748/wjg.v24.i20.2152. PMID: 29853733Free PMC Article
Thyagarajan MS, Sharif K
Indian J Pediatr 2016 Nov;83(11):1291-1302. Epub 2016 Oct 25 doi: 10.1007/s12098-016-2240-x. PMID: 27783314
Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733Free PMC Article

Clinical prediction guides

Haberman DM, Andriani OC, Segaran NL, Volpacchio MM, Micheli ML, Russi RH, Pérez Fernández IA
Radiographics 2022 Jan-Feb;42(1):106-124. doi: 10.1148/rg.210067. PMID: 34990325
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138. Epub 2020 Jun 11 doi: 10.1038/s41586-020-2394-6. PMID: 32528174
Machado MAC, Surjan RC, Makdissi F
Ann Surg Oncol 2020 Apr;27(4):1174-1179. Epub 2019 Nov 4 doi: 10.1245/s10434-019-08027-x. PMID: 31686346
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478Free PMC Article

Recent systematic reviews

Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613
Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M
Cochrane Database Syst Rev 2020 Mar 2;3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3. PMID: 32118296Free PMC Article

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