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Neuroma

MedGen UID:
14352
•Concept ID:
C0027858
•
Neoplastic Process
Synonym: Neuromas
SNOMED CT: Neuroma (443892003); Neuroma (1163436007)
 
HPO: HP:0030430
Monarch Initiative: MONDO:0002173

Definition

A tumor made up of nerve cells and nerve fibers. [from HPO]

Professional guidelines

PubMed

Differential Diagnosis of Metatarsalgia.
Afonso PD, Britto SV, Spritzer CE, Martins E Souza P
Semin Musculoskelet Radiol 2023 Jun;27(3):337-350. Epub 2023 May 25 doi: 10.1055/s-0043-1764388. PMID: 37230133
Neuropathic Pain: From Mechanisms to Treatment.
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Heel Pain: Diagnosis and Management.
Tu P
Am Fam Physician 2018 Jan 15;97(2):86-93. PMID: 29365222

Recent clinical studies

Etiology

Vestibular Schwannoma: What We Know and Where We are Heading.
Gupta VK, Thakker A, Gupta KK
Head Neck Pathol 2020 Dec;14(4):1058-1066. Epub 2020 Mar 30 doi: 10.1007/s12105-020-01155-x. PMID: 32232723Free PMC Article
Etiology and Treatment Outcomes for Sural Neuroma.
Lans J, Gamo L, DiGiovanni CW, Chen NC, Eberlin KR
Foot Ankle Int 2019 May;40(5):545-552. Epub 2019 Feb 2 doi: 10.1177/1071100719828375. PMID: 30712380
Metatarsalgia.
Hodes A, Umans H
Radiol Clin North Am 2018 Nov;56(6):877-892. doi: 10.1016/j.rcl.2018.06.004. PMID: 30322488
Treatment of Morton's neuroma: A systematic review.
Valisena S, Petri GJ, Ferrero A
Foot Ankle Surg 2018 Aug;24(4):271-281. Epub 2017 Apr 5 doi: 10.1016/j.fas.2017.03.010. PMID: 29409240
Morton neuroma and metatarsalgia.
Wu KK
Curr Opin Rheumatol 2000 Mar;12(2):131-42. doi: 10.1097/00002281-200003000-00007. PMID: 10751016

Diagnosis

Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Morton's neuroma: review of anatomy, pathomechanism, and imaging.
Mak MS, Chowdhury R, Johnson R
Clin Radiol 2021 Mar;76(3):235.e15-235.e23. Epub 2020 Nov 7 doi: 10.1016/j.crad.2020.10.006. PMID: 33168237
Revision of Recurrent Neuromas.
Frush K, Niester A
Clin Podiatr Med Surg 2020 Jul;37(3):521-532. Epub 2020 May 12 doi: 10.1016/j.cpm.2020.03.007. PMID: 32471616
Vestibular Schwannoma: What We Know and Where We are Heading.
Gupta VK, Thakker A, Gupta KK
Head Neck Pathol 2020 Dec;14(4):1058-1066. Epub 2020 Mar 30 doi: 10.1007/s12105-020-01155-x. PMID: 32232723Free PMC Article
Neuroma.
Neumeister MW, Winters JN
Clin Plast Surg 2020 Apr;47(2):279-283. Epub 2020 Jan 31 doi: 10.1016/j.cps.2019.12.008. PMID: 32115053

Therapy

Common Painful Foot and Ankle Conditions: A Review.
Cooper MT
JAMA 2023 Dec 19;330(23):2285-2294. doi: 10.1001/jama.2023.23906. PMID: 38112812
A Critical Overview of Targeted Therapies for Vestibular Schwannoma.
Tamura R, Toda M
Int J Mol Sci 2022 May 13;23(10) doi: 10.3390/ijms23105462. PMID: 35628268Free PMC Article
Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Non-surgical treatments for Morton's neuroma: A systematic review.
Thomson L, Aujla RS, Divall P, Bhatia M
Foot Ankle Surg 2020 Oct;26(7):736-743. Epub 2019 Nov 2 doi: 10.1016/j.fas.2019.09.009. PMID: 31718949
Treatment of Morton's neuroma: A systematic review.
Valisena S, Petri GJ, Ferrero A
Foot Ankle Surg 2018 Aug;24(4):271-281. Epub 2017 Apr 5 doi: 10.1016/j.fas.2017.03.010. PMID: 29409240

Prognosis

Incidence, Diagnosis, and Management of Neuromas Following Radiofrequency Ablation Treatment: a Narrative Review.
Schmidt S, Karri J, Singh M, Abd-Elsayed A
Curr Pain Headache Rep 2021 May 7;25(7):45. doi: 10.1007/s11916-021-00964-1. PMID: 33961177
Vestibular Schwannomas.
Carlson ML, Link MJ
N Engl J Med 2021 Apr 8;384(14):1335-1348. doi: 10.1056/NEJMra2020394. PMID: 33826821
Radiation therapy for vestibular schwannomas.
Mulder JJ, Kaanders JH, van Overbeeke JJ, Cremers CW
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):367-71. doi: 10.1097/MOO.0b013e328357d337. PMID: 22931906
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113
Acoustic schwannoma.
Chandler CL, Ramsden RT
Br J Hosp Med 1993 Mar 3-16;49(5):335-43. PMID: 8472085

Clinical prediction guides

Plantar and dorsal approaches for excision of morton's neuroma: a comparison study.
Xu W, Zhang N, Li Z, Wang Y, Li X, Wang Y, Si H, Hu Y
BMC Musculoskelet Disord 2022 Oct 6;23(1):898. doi: 10.1186/s12891-022-05858-w. PMID: 36203146Free PMC Article
Interdigital Commissural Approach for Morton's Neuroma.
Yañez Arauz JM
Foot Ankle Int 2020 Oct;41(10):1226-1233. Epub 2020 Jul 16 doi: 10.1177/1071100720936599. PMID: 32674597
Prediction of Clinical Prognosis according to Intermetatarsal Distance and Neuroma Size on Ultrasonography in Morton Neuroma: A Prospective Observational Study.
Park YH, Kim TJ, Choi GW, Kim HJ
J Ultrasound Med 2019 Apr;38(4):1009-1014. Epub 2018 Sep 23 doi: 10.1002/jum.14787. PMID: 30244477
Growth rate of vestibular schwannoma.
Paldor I, Chen AS, Kaye AH
J Clin Neurosci 2016 Oct;32:1-8. Epub 2016 Jul 20 doi: 10.1016/j.jocn.2016.05.003. PMID: 27450283
Hearing preservation: microsurgery.
Kari E, Friedman RA
Curr Opin Otolaryngol Head Neck Surg 2012 Oct;20(5):358-66. doi: 10.1097/MOO.0b013e3283579673. PMID: 22929113

Recent systematic reviews

Treatment for vestibular schwannoma: Systematic review and single arm meta-analysis.
Thai NLB, Mai NY, Vuong NL, Tin NM, Karam D, Refaey MA, Shahin KM, Soliman AL, Al Khudari R, Thuan TM, Sabbah GM, El-Qushayri AE, Karimzadeh S, Hirayama K, Huy NT
Am J Otolaryngol 2022 Mar-Apr;43(2):103337. Epub 2021 Dec 20 doi: 10.1016/j.amjoto.2021.103337. PMID: 34973662
Extracorporeal Shockwave Therapy for Foot and Ankle Disorders: A Systematic Review and Meta-Analysis.
Nazim B Tengku Yusof T, Seow D, Vig KS
J Am Podiatr Med Assoc 2022 May-Jun;112(3) doi: 10.7547/18-191. PMID: 34878537
Non-surgical treatments for Morton's neuroma: A systematic review.
Thomson L, Aujla RS, Divall P, Bhatia M
Foot Ankle Surg 2020 Oct;26(7):736-743. Epub 2019 Nov 2 doi: 10.1016/j.fas.2019.09.009. PMID: 31718949
The effectiveness of non-surgical interventions for common plantar digital compressive neuropathy (Morton's neuroma): a systematic review and meta-analysis.
Matthews BG, Hurn SE, Harding MP, Henry RA, Ware RS
J Foot Ankle Res 2019;12:12. Epub 2019 Feb 13 doi: 10.1186/s13047-019-0320-7. PMID: 30809275Free PMC Article
Treatment of Morton's neuroma: A systematic review.
Valisena S, Petri GJ, Ferrero A
Foot Ankle Surg 2018 Aug;24(4):271-281. Epub 2017 Apr 5 doi: 10.1016/j.fas.2017.03.010. PMID: 29409240

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