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Organic mental disorder

MedGen UID:
14510
•Concept ID:
C0029227
•
Mental or Behavioral Dysfunction
Synonyms: Delirium, Dementia, Amnestic, Cognitive Disorders; Disorders, Organic Mental; Mental Disorder, Organic; Mental Disorders, Organic; Organic Mental Disorder; Organic Mental Disorders
SNOMED CT: Organic mental disorder (111479008)

Definition

Any decrease in mental functioning in which the cause is not attributable to psychiatric illness, which includes damage from physical trauma, anoxic injury, damage from chemicals or toxins, infection, cancer, and degenerative diseases, including Alzheimer''s disease, Huntington''s disease, Parkinson''s disease, and Creutzfeldt-Jakob disease. [from NCI]

Professional guidelines

PubMed

Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study.
Chen CK, Yang SY, Park SC, Jang OJ, Zhu X, Xiang YT, Ouyang WC, Javed A, Khan MNS, Grover S, Avasthi A, Kallivayalil RA, Chee KY, Chemi N, Kato TA, Hayakawa K, Pariwatcharakul P, Maramis M, Seneviratne L, Sim K, Tang WK, Oo T, Sartorius N, Tan CH, Chong MY, Park YC, Shinfuku N, Lin SK
Asian J Psychiatr 2023 Jul;85:103613. Epub 2023 Apr 28 doi: 10.1016/j.ajp.2023.103613. PMID: 37163943
Excess mortality and risk factors for mortality among patients with severe mental disorders receiving home care case management.
Chen WY, Huang SJ, Chang CK, Pan CH, Su SS, Yang TW, Kuo CJ
Nord J Psychiatry 2021 Feb;75(2):109-117. Epub 2020 Aug 4 doi: 10.1080/08039488.2020.1799431. PMID: 32749171
The Role of Statins in the Management of Delirium: Recent Advances.
Chen J, Wang Y, Hu X, Li M, Xiong K, Zhang Z, Chen Q
CNS Neurol Disord Drug Targets 2021 Oct 26;20(3):203-215. doi: 10.2174/1871527319666200720111318. PMID: 32691721

Recent clinical studies

Etiology

Loneliness in Elderly Inpatients.
Just SA, Seethaler M, Sarpeah R, Waßmuth N, Bermpohl F, Brandl EJ
Psychiatr Q 2022 Dec;93(4):1017-1030. Epub 2022 Nov 9 doi: 10.1007/s11126-022-10006-7. PMID: 36350482Free PMC Article
Association between Mental Disorders and Subsequent Medical Conditions.
Momen NC, Plana-Ripoll O, Agerbo E, Benros ME, Børglum AD, Christensen MK, Dalsgaard S, Degenhardt L, de Jonge P, Debost JPG, Fenger-Grøn M, Gunn JM, Iburg KM, Kessing LV, Kessler RC, Laursen TM, Lim CCW, Mors O, Mortensen PB, Musliner KL, Nordentoft M, Pedersen CB, Petersen LV, Ribe AR, Roest AM, Saha S, Schork AJ, Scott KM, Sievert C, Sørensen HJ, Stedman TJ, Vestergaard M, Vilhjalmsson B, Werge T, Weye N, Whiteford HA, Prior A, McGrath JJ
N Engl J Med 2020 Apr 30;382(18):1721-1731. doi: 10.1056/NEJMoa1915784. PMID: 32348643Free PMC Article
Depression and ionizing radiation.
Loganovsky KN, Vasilenko ZL
Probl Radiac Med Radiobiol 2013;(18):200-19. PMID: 25191725
Quantifying undiagnosed organic mental disorder in geriatric inpatients.
Sheline Y
Hosp Community Psychiatry 1990 Sep;41(9):1004-8. doi: 10.1176/ps.41.9.1004. PMID: 2210693
Psychiatric emergencies.
Cavanaugh SV
Med Clin North Am 1986 Sep;70(5):1185-202. doi: 10.1016/s0025-7125(16)30919-1. PMID: 3736271

Diagnosis

Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study.
Chen CK, Yang SY, Park SC, Jang OJ, Zhu X, Xiang YT, Ouyang WC, Javed A, Khan MNS, Grover S, Avasthi A, Kallivayalil RA, Chee KY, Chemi N, Kato TA, Hayakawa K, Pariwatcharakul P, Maramis M, Seneviratne L, Sim K, Tang WK, Oo T, Sartorius N, Tan CH, Chong MY, Park YC, Shinfuku N, Lin SK
Asian J Psychiatr 2023 Jul;85:103613. Epub 2023 Apr 28 doi: 10.1016/j.ajp.2023.103613. PMID: 37163943
Loneliness in Elderly Inpatients.
Just SA, Seethaler M, Sarpeah R, Waßmuth N, Bermpohl F, Brandl EJ
Psychiatr Q 2022 Dec;93(4):1017-1030. Epub 2022 Nov 9 doi: 10.1007/s11126-022-10006-7. PMID: 36350482Free PMC Article
Association between Mental Disorders and Subsequent Medical Conditions.
Momen NC, Plana-Ripoll O, Agerbo E, Benros ME, Børglum AD, Christensen MK, Dalsgaard S, Degenhardt L, de Jonge P, Debost JPG, Fenger-Grøn M, Gunn JM, Iburg KM, Kessing LV, Kessler RC, Laursen TM, Lim CCW, Mors O, Mortensen PB, Musliner KL, Nordentoft M, Pedersen CB, Petersen LV, Ribe AR, Roest AM, Saha S, Schork AJ, Scott KM, Sievert C, Sørensen HJ, Stedman TJ, Vestergaard M, Vilhjalmsson B, Werge T, Weye N, Whiteford HA, Prior A, McGrath JJ
N Engl J Med 2020 Apr 30;382(18):1721-1731. doi: 10.1056/NEJMoa1915784. PMID: 32348643Free PMC Article
Psychiatric emergencies.
Cavanaugh SV
Med Clin North Am 1986 Sep;70(5):1185-202. doi: 10.1016/s0025-7125(16)30919-1. PMID: 3736271
Overview: pseudodementia.
McAllister TW
Am J Psychiatry 1983 May;140(5):528-33. doi: 10.1176/ajp.140.5.528. PMID: 6342420

Therapy

Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study.
Chen CK, Yang SY, Park SC, Jang OJ, Zhu X, Xiang YT, Ouyang WC, Javed A, Khan MNS, Grover S, Avasthi A, Kallivayalil RA, Chee KY, Chemi N, Kato TA, Hayakawa K, Pariwatcharakul P, Maramis M, Seneviratne L, Sim K, Tang WK, Oo T, Sartorius N, Tan CH, Chong MY, Park YC, Shinfuku N, Lin SK
Asian J Psychiatr 2023 Jul;85:103613. Epub 2023 Apr 28 doi: 10.1016/j.ajp.2023.103613. PMID: 37163943
The Role of Statins in the Management of Delirium: Recent Advances.
Chen J, Wang Y, Hu X, Li M, Xiong K, Zhang Z, Chen Q
CNS Neurol Disord Drug Targets 2021 Oct 26;20(3):203-215. doi: 10.2174/1871527319666200720111318. PMID: 32691721
Trauma-focused psychodynamic therapy and STAIR Narrative Therapy of post-traumatic stress disorder related to childhood maltreatment: trial protocol of a multicentre randomised controlled trial assessing psychological, neurobiological and health economic outcomes (ENHANCE).
Leichsenring F, Steinert C, Beutel ME, Feix L, Gündel H, Hermann A, Karabatsiakis A, Knaevelsrud C, König HH, Kolassa IT, Kruse J, Niemeyer H, Nöske F, Palmer S, Peters E, Reese JP, Reuss A, Salzer S, Schade-Brittinger C, Schuster P, Stark R, Weidner K, von Wietersheim J, Witthöft M, Wöller W, Hoyer J
BMJ Open 2020 Dec 17;10(12):e040123. doi: 10.1136/bmjopen-2020-040123. PMID: 33334832Free PMC Article
Depression and ionizing radiation.
Loganovsky KN, Vasilenko ZL
Probl Radiac Med Radiobiol 2013;(18):200-19. PMID: 25191725
Overview: pseudodementia.
McAllister TW
Am J Psychiatry 1983 May;140(5):528-33. doi: 10.1176/ajp.140.5.528. PMID: 6342420

Prognosis

Loneliness in Elderly Inpatients.
Just SA, Seethaler M, Sarpeah R, Waßmuth N, Bermpohl F, Brandl EJ
Psychiatr Q 2022 Dec;93(4):1017-1030. Epub 2022 Nov 9 doi: 10.1007/s11126-022-10006-7. PMID: 36350482Free PMC Article
Survival Rate Following Involuntary Electroconvulsive Therapy: A Population-Based Study.
Salagre E, Rohde C, Ishtiak-Ahmed K, Gasse C, Østergaard SD
J ECT 2021 Jun 1;37(2):94-99. doi: 10.1097/YCT.0000000000000736. PMID: 33337646
Microsurgical tissue transfers for head and neck reconstruction in patients with alcohol-induced mental disorder.
Kuo YR, Jeng SF, Lin KM, Hou SJ, Su CY, Chien CY, Hsueh KL, Huang EY
Ann Surg Oncol 2008 Jan;15(1):371-7. Epub 2007 Nov 1 doi: 10.1245/s10434-007-9506-5. PMID: 17973172
Personality disorder and the Temperament and Character Inventory in the elderly.
Casey JE, Joyce PR
Acta Psychiatr Scand 1999 Oct;100(4):302-8. doi: 10.1111/j.1600-0447.1999.tb10865.x. PMID: 10510700
Overview: pseudodementia.
McAllister TW
Am J Psychiatry 1983 May;140(5):528-33. doi: 10.1176/ajp.140.5.528. PMID: 6342420

Clinical prediction guides

Clinical features and outcomes of COVID-19 patients hospitalized for psychiatric disorders: a French multi-centered prospective observational study.
Dobre D, Schwan R, Jansen C, Schwitzer T, Martin O, Ligier F, Rolland B, Ahad PA, Capdevielle D, Corruble E, Delamillieure P, Dollfus S, Drapier D, Bennabi D, Joubert F, Lecoeur W, Massoubre C, Pelissolo A, Roser M, Schmitt C, Teboul N, Vansteene C, Yekhlef W, Yrondi A, Haoui R, Gaillard R, Leboyer M, Thomas P, Gorwood P, Laprevote V
Psychol Med 2023 Jan;53(2):342-350. Epub 2021 Apr 27 doi: 10.1017/S0033291721001537. PMID: 33902760Free PMC Article
Loneliness in Elderly Inpatients.
Just SA, Seethaler M, Sarpeah R, Waßmuth N, Bermpohl F, Brandl EJ
Psychiatr Q 2022 Dec;93(4):1017-1030. Epub 2022 Nov 9 doi: 10.1007/s11126-022-10006-7. PMID: 36350482Free PMC Article
Trauma-focused psychodynamic therapy and STAIR Narrative Therapy of post-traumatic stress disorder related to childhood maltreatment: trial protocol of a multicentre randomised controlled trial assessing psychological, neurobiological and health economic outcomes (ENHANCE).
Leichsenring F, Steinert C, Beutel ME, Feix L, Gündel H, Hermann A, Karabatsiakis A, Knaevelsrud C, König HH, Kolassa IT, Kruse J, Niemeyer H, Nöske F, Palmer S, Peters E, Reese JP, Reuss A, Salzer S, Schade-Brittinger C, Schuster P, Stark R, Weidner K, von Wietersheim J, Witthöft M, Wöller W, Hoyer J
BMJ Open 2020 Dec 17;10(12):e040123. doi: 10.1136/bmjopen-2020-040123. PMID: 33334832Free PMC Article
Depression and ionizing radiation.
Loganovsky KN, Vasilenko ZL
Probl Radiac Med Radiobiol 2013;(18):200-19. PMID: 25191725
Bipolar disorder: similarities and differences between patients with illness onset before and after 65 years of age.
Almeida OP, Fenner S
Int Psychogeriatr 2002 Sep;14(3):311-22. doi: 10.1017/s1041610202008517. PMID: 12475092

Recent systematic reviews

Factor Structure of Cotard's Syndrome: Systematic Review of Case Reports.
Huarcaya-Victoria J, Bojórquez-De la Torre J, De la Cruz-Oré J
Rev Colomb Psiquiatr (Engl Ed) 2020 Jul-Sep;49(3):187-193. Epub 2018 Dec 3 doi: 10.1016/j.rcp.2018.10.008. PMID: 32888662

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