U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bone benign neoplasm

MedGen UID:
146337
•Concept ID:
C0684516
•
Neoplastic Process
Synonyms: Benign Bone Neoplasm; benign bone neoplasm; Benign bone tumor; Benign Bone Tumor; benign bone tumor; benign bone tumour; Benign neoplasm of bone; Benign Neoplasm of Bone; benign neoplasm of bone; Benign Neoplasm of the Bone; benign neoplasm of the bone; Benign Osseous Neoplasm; benign osseous neoplasm; Benign Osseous Tumor; benign osseous tumor; benign osseous tumour; Benign Tumor of Bone; benign tumor of bone; Benign Tumor of the Bone; benign tumor of the bone; benign tumour of bone; benign tumour of the bone; bone benign neoplasm; bone tissue benign neoplasm
SNOMED CT: Benign neoplasm of bone (92027006); Benign bone tumor (92027006)
 
Monarch Initiative: MONDO:0000631

Definition

A mesenchymal neoplasm that arises from bone or articular cartilage and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations.
Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110
The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients.
Desmoid Tumor Working Group
Eur J Cancer 2020 Mar;127:96-107. Epub 2020 Jan 28 doi: 10.1016/j.ejca.2019.11.013. PMID: 32004793
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BG, Miguel JF
Lancet Oncol 2014 Nov;15(12):e538-48. Epub 2014 Oct 26 doi: 10.1016/S1470-2045(14)70442-5. PMID: 25439696

Recent clinical studies

Etiology

Benign tumours and tumour like lesions of bone.
Atif M, Ali Hasan OH, Ashraf U, Mustafa M, Umer M
J Pak Med Assoc 2018 Oct;68(10):1502-1507. PMID: 30317350
Animal models for bone tissue engineering and modelling disease.
McGovern JA, Griffin M, Hutmacher DW
Dis Model Mech 2018 Apr 23;11(4) doi: 10.1242/dmm.033084. PMID: 29685995Free PMC Article
Cancer Treatment and Bone Health.
Handforth C, D'Oronzo S, Coleman R, Brown J
Calcif Tissue Int 2018 Feb;102(2):251-264. Epub 2018 Jan 20 doi: 10.1007/s00223-017-0369-x. PMID: 29353450Free PMC Article
Hypoxia and Bone Metastatic Disease.
Johnson RW, Sowder ME, Giaccia AJ
Curr Osteoporos Rep 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. PMID: 28597139Free PMC Article
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652

Diagnosis

Understanding Unicameral and Aneurysmal Bone Cysts.
Rosenblatt J, Koder A
Pediatr Rev 2019 Feb;40(2):51-59. doi: 10.1542/pir.2015-0128. PMID: 30709971
Benign tumours and tumour like lesions of bone.
Atif M, Ali Hasan OH, Ashraf U, Mustafa M, Umer M
J Pak Med Assoc 2018 Oct;68(10):1502-1507. PMID: 30317350
Multiparametric MR Imaging of Benign and Malignant Bone Lesions.
Tang H, Ahlawat S, Fayad LM
Magn Reson Imaging Clin N Am 2018 Nov;26(4):559-569. doi: 10.1016/j.mric.2018.06.010. PMID: 30316467
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Exercise and cancer.
Knobf MT, Winters-Stone K
Annu Rev Nurs Res 2013;31:327-65. doi: 10.1891/0739-6686.31.327. PMID: 24894145

Therapy

Bone metastasis: mechanisms, therapies, and biomarkers.
Clézardin P, Coleman R, Puppo M, Ottewell P, Bonnelye E, Paycha F, Confavreux CB, Holen I
Physiol Rev 2021 Jul 1;101(3):797-855. Epub 2020 Dec 24 doi: 10.1152/physrev.00012.2019. PMID: 33356915
Basic and clinical associations between bone and cancer.
He F, Matsumoto Y
Immunol Med 2020 Sep;43(3):103-106. Epub 2020 Apr 17 doi: 10.1080/25785826.2020.1754084. PMID: 32301686
Cancer Treatment and Bone Health.
Handforth C, D'Oronzo S, Coleman R, Brown J
Calcif Tissue Int 2018 Feb;102(2):251-264. Epub 2018 Jan 20 doi: 10.1007/s00223-017-0369-x. PMID: 29353450Free PMC Article
Exercise and cancer.
Knobf MT, Winters-Stone K
Annu Rev Nurs Res 2013;31:327-65. doi: 10.1891/0739-6686.31.327. PMID: 24894145
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652

Prognosis

Primary Leiomyosarcoma of Bone: Review and Update.
Wang GY, Lucas DR
Arch Pathol Lab Med 2019 Nov;143(11):1332-1337. doi: 10.5858/arpa.2019-0375-RA. PMID: 31661313
Imaging of Multiple Myeloma.
Kosmala A, Bley T, Petritsch B
Rofo 2019 Sep;191(9):805-816. Epub 2019 Jun 11 doi: 10.1055/a-0864-2084. PMID: 31185511
Benign tumours and tumour like lesions of bone.
Atif M, Ali Hasan OH, Ashraf U, Mustafa M, Umer M
J Pak Med Assoc 2018 Oct;68(10):1502-1507. PMID: 30317350
Hallmarks of Bone Metastasis.
Johnson RW, Suva LJ
Calcif Tissue Int 2018 Feb;102(2):141-151. Epub 2017 Nov 14 doi: 10.1007/s00223-017-0362-4. PMID: 29138883Free PMC Article
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652

Clinical prediction guides

Novel Techniques to Study the Bone-Tumor Microenvironment.
Shupp AB, Kolb AD, Bussard KM
Adv Exp Med Biol 2020;1225:1-18. doi: 10.1007/978-3-030-35727-6_1. PMID: 32030644
Adrenocortical incidentalomas and bone: from molecular insights to clinical perspectives.
Altieri B, Muscogiuri G, Paschou SA, Vryonidou A, Della Casa S, Pontecorvi A, Fassnacht M, Ronchi CL, Newell-Price J
Endocrine 2018 Dec;62(3):506-516. Epub 2018 Aug 2 doi: 10.1007/s12020-018-1696-z. PMID: 30073456
Endothelin Signaling in Bone.
Kristianto J, Johnson MG, Afzal R, Blank RD
Endocrinol Metab Clin North Am 2017 Mar;46(1):51-62. Epub 2016 Nov 26 doi: 10.1016/j.ecl.2016.09.014. PMID: 28131136Free PMC Article
The Bone Microenvironment: a Fertile Soil for Tumor Growth.
Buenrostro D, Mulcrone PL, Owens P, Sterling JA
Curr Osteoporos Rep 2016 Aug;14(4):151-8. doi: 10.1007/s11914-016-0315-2. PMID: 27255469Free PMC Article
MicroRNAs in osteosarcomagenesis.
Kafchinski LA, Jones KB
Adv Exp Med Biol 2014;804:119-27. doi: 10.1007/978-3-319-04843-7_6. PMID: 24924171

Recent systematic reviews

ESTRO clinical practice guideline: Stereotactic body radiotherapy for spine metastases.
Guckenberger M, Andratschke N, Belka C, Bellut D, Cuccia F, Dahele M, Guninski RS, Josipovic M, Mancosu P, Minniti G, Niyazi M, Ricardi U, Munck Af Rosenschold P, Sahgal A, Tsang Y, Verbakel W, Alongi F
Radiother Oncol 2024 Jan;190:109966. Epub 2023 Nov 2 doi: 10.1016/j.radonc.2023.109966. PMID: 37925107
Papilliferous Keratoameloblastoma: Systematic review.
Sachdev SS, Chettiankandy TJ, Adhane YB, Sardar MA, Trimukhe A, Jain R
Sultan Qaboos Univ Med J 2023 Aug;23(3):288-296. Epub 2023 Aug 28 doi: 10.18295/squmj.5.2023.021. PMID: 37655071Free PMC Article
Head-to-head Comparison of the Diagnostic Accuracy of Prostate-specific Membrane Antigen Positron Emission Tomography and Conventional Imaging Modalities for Initial Staging of Intermediate- to High-risk Prostate Cancer: A Systematic Review and Meta-analysis.
Chow KM, So WZ, Lee HJ, Lee A, Yap DWT, Takwoingi Y, Tay KJ, Tuan J, Thang SP, Lam W, Yuen J, Lawrentschuk N, Hofman MS, Murphy DG, Chen K
Eur Urol 2023 Jul;84(1):36-48. Epub 2023 Apr 7 doi: 10.1016/j.eururo.2023.03.001. PMID: 37032189
Skull base hemangiopericytomas.
Tobias S, Jahshan S, Grober Y, Soustiel JF
Acta Neurol Belg 2022 Dec;122(6):1537-1545. Epub 2021 Sep 30 doi: 10.1007/s13760-021-01812-0. PMID: 34595730
Osteoradionecrosis: Exposing the Evidence Not the Bone.
Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1206-1218. Epub 2021 Jan 4 doi: 10.1016/j.ijrobp.2020.12.043. PMID: 33412258

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...