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Bone Hibernoma

MedGen UID:
1791591
•Concept ID:
C5555150
•
Neoplastic Process

Definition

A benign neoplasm that is composed of brown adipocytes and arises within or on the surface of bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Hibernoma

Professional guidelines

PubMed

Toward clinical and molecular dissection of frontonasal dysplasia with facial skin polyps: From Pai syndrome to differential diagnosis through a series of 27 patients.
Lehalle D, Bruel AL, Vitobello A, Denommé-Pichon AS, Duffourd Y, Assoum M, Amiel J, Baujat G, Bessieres B, Bigoni S, Burglen L, Captier G, Dard R, Edery P, Fortunato F, Geneviève D, Goldenberg A, Guibaud L, Héron D, Holder-Espinasse M, Lederer D, Lopez Grondona F, Grotto S, Marlin S, Nadeau G, Picard A, Rossi M, Roume J, Sanlaville D, Saugier-Veber P, Triau S, Valenzuela Palafoll MI, Vanlerberghe C, Van Maldergem L, Vezain M, Vincent-Delorme C, Zivi E, Thevenon J, Vabres P, Thauvin-Robinet C, Callier P, Faivre L
Am J Med Genet A 2022 Jul;188(7):2036-2047. Epub 2022 Apr 21 doi: 10.1002/ajmg.a.62739. PMID: 35445792
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Clinical evaluation and management of benign soft tissue tumors of the extremities.
Erwteman AS, Balach T
Cancer Treat Res 2014;162:171-202. doi: 10.1007/978-3-319-07323-1_9. PMID: 25070236

Recent clinical studies

Etiology

Bone and soft tissue tumors at the borderlands of malignancy.
Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Orthopedic issues in vascular anomalies.
Spencer SA, Sorger JI
Semin Pediatr Surg 2020 Oct;29(5):150973. Epub 2020 Sep 19 doi: 10.1016/j.sempedsurg.2020.150973. PMID: 33069292
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Temperatures rising: brown fat and bone.
Motyl KJ, Rosen CJ
Discov Med 2011 Mar;11(58):179-85. PMID: 21447277Free PMC Article

Diagnosis

Ultrasound of congenital spine anomalies.
Rees MA, Squires JH, Coley BD, Hoehne B, Ho ML
Pediatr Radiol 2021 Dec;51(13):2442-2457. Epub 2021 Sep 16 doi: 10.1007/s00247-021-05178-6. PMID: 34532816
Calcaneal Bone Tumors.
Temple EW, Prusa RD
Clin Podiatr Med Surg 2021 Apr;38(2):227-233. Epub 2021 Jan 26 doi: 10.1016/j.cpm.2020.12.007. PMID: 33745653
Atypical spindle cell/pleomorphic lipomatous tumor.
Lecoutere E, Creytens D
Histol Histopathol 2020 Aug;35(8):769-778. Epub 2020 Feb 18 doi: 10.14670/HH-18-210. PMID: 32068239
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Orbital lipoma.
Koganei Y, Ishikawa S, Abe K, Mukuno K, Shioya N
Ann Plast Surg 1988 Feb;20(2):173-82. doi: 10.1097/00000637-198802000-00017. PMID: 3281547

Therapy

Transcutaneous electrical stimulation therapy and genetic analysis in Dercum's disease: A pilot study.
Caretto A, Errichiello E, Patricelli MG, Zuffardi O, Cristel G, Ravelli S, Sirtori M, Scavini M, Bosi E, Martinenghi S
Medicine (Baltimore) 2021 Dec 23;100(51):e28360. doi: 10.1097/MD.0000000000028360. PMID: 34941153Free PMC Article
Tumors of the foot and ankle: a single-institution experience.
Azevedo CP, Casanova JM, Guerra MG, Santos AL, Portela MI, Tavares PF
J Foot Ankle Surg 2013 Mar-Apr;52(2):147-52. Epub 2013 Jan 16 doi: 10.1053/j.jfas.2012.12.004. PMID: 23333280
US of the spinal cord in newborns: spectrum of normal findings, variants, congenital anomalies, and acquired diseases.
Unsinn KM, Geley T, Freund MC, Gassner I
Radiographics 2000 Jul-Aug;20(4):923-38. doi: 10.1148/radiographics.20.4.g00jl06923. PMID: 10903684
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432
Interscapular syndrome.
Kinariwala VJ, Shah BR
J Assoc Physicians India 1971 Aug;19(8):579-83. PMID: 5118237

Prognosis

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Orthopedic issues in vascular anomalies.
Spencer SA, Sorger JI
Semin Pediatr Surg 2020 Oct;29(5):150973. Epub 2020 Sep 19 doi: 10.1016/j.sempedsurg.2020.150973. PMID: 33069292
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Oncologic conditions that simulate common sports injuries.
Krych A, Odland A, Rose P, Dahm D, Levy B, Wenger D, Stuart M, Sim F
J Am Acad Orthop Surg 2014 Apr;22(4):223-34. doi: 10.5435/JAAOS-22-04-223. PMID: 24668352
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Clinical prediction guides

Intraosseous hibernoma: clinicopathologic and imaging analysis of 18 cases.
Gangahar CN, Dehner CA, Wang DP, Amini B, Hillen T, O'Conor C, Jennings SN, Byrnes K, Montgomery EA, Czerniak BA, Bridge JA, Schroeder MC, Jennings JW, Wang WL, Chrisinger JSA
Histopathology 2023 Jul;83(1):40-48. Epub 2023 Apr 26 doi: 10.1111/his.14928. PMID: 37099409
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Proteus syndrome review: molecular, clinical, and pathologic features.
Cohen MM Jr
Clin Genet 2014 Feb;85(2):111-9. Epub 2013 Oct 23 doi: 10.1111/cge.12266. PMID: 23992099
Temperatures rising: brown fat and bone.
Motyl KJ, Rosen CJ
Discov Med 2011 Mar;11(58):179-85. PMID: 21447277Free PMC Article

Recent systematic reviews

Head and neck lipoblastoma in children: A case report and systematic review.
Tyra J, Mierzwińska-Dolny P, Fishman AJ, Mierzwiński J
Int J Pediatr Otorhinolaryngol 2023 Oct;173:111699. Epub 2023 Aug 16 doi: 10.1016/j.ijporl.2023.111699. PMID: 37597314
In Reply to the Letter to the Editor Regarding "Nondysraphic Intramedullary Lipoma of the Cervical Spine: A Systematic Review of Management Strategies and Outcomes".
Grasso G, Kim HS, Torregrossa F
World Neurosurg 2023 Jul;175:162. doi: 10.1016/j.wneu.2023.04.061. PMID: 37365759
Nondysraphic Intramedullary Lipoma of the Cervical Spine: A Systematic Review of Management Strategies and Outcomes.
Grasso G, Paolini F, Sallì M, Kim HS, Torregrossa F
World Neurosurg 2023 Jun;174:197-204.e1. Epub 2023 Mar 4 doi: 10.1016/j.wneu.2023.02.131. PMID: 36871652
Liponeurocytoma: Systematic Review of a Rare Entity.
Gembruch O, Junker A, Mönninghoff C, Ahmadipour Y, Darkwah Oppong M, Sure U, El Hindy N, Lemonas E
World Neurosurg 2018 Dec;120:214-233. Epub 2018 Sep 8 doi: 10.1016/j.wneu.2018.09.001. PMID: 30205225
Iatrogenic surgical microscope skin burns: A systematic review of the literature and case report.
Lopez J, Soni A, Calva D, Susarla SM, Jallo GI, Redett R
Burns 2016 Jun;42(4):e74-80. Epub 2016 Jan 15 doi: 10.1016/j.burns.2015.08.014. PMID: 26777456

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