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Motor seizure

MedGen UID:
148322
•Concept ID:
C0751494
•
Sign or Symptom
Synonyms: Convulsive Seizure; Convulsive Seizures; Motor Seizure; Motor Seizures; Seizure, Convulsive; Seizure, Motor; Seizures, Convulsive; Seizures, Motor
 
HPO: HP:0020219

Definition

A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMotor seizure

Professional guidelines

PubMed

The Impact of Clinical Seizure Characteristics on Recognition and Treatment of New-onset Focal Epilepsy in Emergency Departments.
Pellinen J, Tafuro E, Baehr A, Barnard S, Holmes M, French J; Human Epilepsy Project Investigators
Acad Emerg Med 2021 Apr;28(4):412-420. Epub 2020 Sep 16 doi: 10.1111/acem.14114. PMID: 32810323
Concurrent Electroconvulsive Therapy and Bupropion Treatment.
Takala CR, Leung JG, Murphy LL, Geske JR, Palmer BA
J ECT 2017 Sep;33(3):185-189. doi: 10.1097/YCT.0000000000000423. PMID: 28570500
Use of video to facilitate sideline concussion diagnosis and management decision-making.
Davis G, Makdissi M
J Sci Med Sport 2016 Nov;19(11):898-902. Epub 2016 Feb 22 doi: 10.1016/j.jsams.2016.02.005. PMID: 27117715

Recent clinical studies

Etiology

Multimodal nocturnal seizure detection in children with epilepsy: A prospective, multicenter, long-term, in-home trial.
van Westrhenen A, Lazeron RHC, van Dijk JP, Leijten FSS, Thijs RD; Dutch TeleEpilepsy Consortium
Epilepsia 2023 Aug;64(8):2137-2152. Epub 2023 Jun 14 doi: 10.1111/epi.17654. PMID: 37195144
Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE).
Demarest S, Jeste S, Agarwal N, Arkilo D, Asgharnejad M, Hsiao S, Thibert R
Epilepsy Behav 2023 May;142:109173. Epub 2023 Apr 1 doi: 10.1016/j.yebeh.2023.109173. PMID: 37011526
Automated detection of nocturnal motor seizures using an audio-video system.
Armand Larsen S, Terney D, Østerkjerhuus T, Vinding Merinder T, Annala K, Knight A, Beniczky S
Brain Behav 2022 Sep;12(9):e2737. Epub 2022 Aug 8 doi: 10.1002/brb3.2737. PMID: 35939047Free PMC Article
Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial.
Knight EMP, Amin S, Bahi-Buisson N, Benke TA, Cross JH, Demarest ST, Olson HE, Specchio N, Fleming TR, Aimetti AA, Gasior M, Devinsky O; Marigold Trial Group
Lancet Neurol 2022 May;21(5):417-427. doi: 10.1016/S1474-4422(22)00077-1. PMID: 35429480
Using sEMG to identify seizure semiology of motor seizures.
Baumgartner C, Whitmire LE, Voyles SR, Cardenas DP
Seizure 2021 Mar;86:52-59. Epub 2020 Nov 23 doi: 10.1016/j.seizure.2020.11.013. PMID: 33550134

Diagnosis

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Automated detection of nocturnal motor seizures using an audio-video system.
Armand Larsen S, Terney D, Østerkjerhuus T, Vinding Merinder T, Annala K, Knight A, Beniczky S
Brain Behav 2022 Sep;12(9):e2737. Epub 2022 Aug 8 doi: 10.1002/brb3.2737. PMID: 35939047Free PMC Article
Diagnostic Delay in Epilepsy: the Scope of the Problem.
Pellinen J, French J, Knupp KG
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):71. doi: 10.1007/s11910-021-01161-8. PMID: 34817723
Generalized nonmotor (absence) seizures-What do absence, generalized, and nonmotor mean?
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337
Midline spikes.
Yong T, Chayasirisobhon S, Yoshina JS, Tin SN, Tehrani K, Skinner SE, Markus E, Spurgeon BD, Gurbani S
Clin EEG Neurosci 2008 Jan;39(1):28-32. doi: 10.1177/155005940803900110. PMID: 18318416

Therapy

Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE).
Demarest S, Jeste S, Agarwal N, Arkilo D, Asgharnejad M, Hsiao S, Thibert R
Epilepsy Behav 2023 May;142:109173. Epub 2023 Apr 1 doi: 10.1016/j.yebeh.2023.109173. PMID: 37011526
Automated detection of nocturnal motor seizures using an audio-video system.
Armand Larsen S, Terney D, Østerkjerhuus T, Vinding Merinder T, Annala K, Knight A, Beniczky S
Brain Behav 2022 Sep;12(9):e2737. Epub 2022 Aug 8 doi: 10.1002/brb3.2737. PMID: 35939047Free PMC Article
Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial.
Knight EMP, Amin S, Bahi-Buisson N, Benke TA, Cross JH, Demarest ST, Olson HE, Specchio N, Fleming TR, Aimetti AA, Gasior M, Devinsky O; Marigold Trial Group
Lancet Neurol 2022 May;21(5):417-427. doi: 10.1016/S1474-4422(22)00077-1. PMID: 35429480
Psychotropic Medication Effects on Seizure Threshold and Seizure Duration During Electroconvulsive Therapy Stimulus Titration.
Chiao S, Isenberg K, North CS
J ECT 2020 Jun;36(2):115-122. doi: 10.1097/YCT.0000000000000621. PMID: 31609275
Midline spikes.
Yong T, Chayasirisobhon S, Yoshina JS, Tin SN, Tehrani K, Skinner SE, Markus E, Spurgeon BD, Gurbani S
Clin EEG Neurosci 2008 Jan;39(1):28-32. doi: 10.1177/155005940803900110. PMID: 18318416

Prognosis

Intercorrelation of physiological seizure parameters and hormonal changes in electroconvulsive therapy.
Thörnblom E, Gingnell M, Cunningham JL, Landén M, Bodén R
Nord J Psychiatry 2023 Apr;77(3):312-318. Epub 2022 Aug 15 doi: 10.1080/08039488.2022.2107237. PMID: 35968653
Factors Associated With Seizure Adequacy Along the Course of Electroconvulsive Therapy.
Tedeschi EA, Patusco LM, Zahler S, Martini M, Chiavaro da Fonseca R, Magalhães PVS
J ECT 2021 Mar 1;37(1):46-50. doi: 10.1097/YCT.0000000000000716. PMID: 32881781
Concurrent Electroconvulsive Therapy and Bupropion Treatment.
Takala CR, Leung JG, Murphy LL, Geske JR, Palmer BA
J ECT 2017 Sep;33(3):185-189. doi: 10.1097/YCT.0000000000000423. PMID: 28570500
Ictal motor sequences: Lateralization and localization values.
Marashly A, Ewida A, Agarwal R, Younes K, Lüders HO
Epilepsia 2016 Mar;57(3):369-75. Epub 2016 Feb 11 doi: 10.1111/epi.13322. PMID: 26864781
Child neurology: hemiconvulsion-hemiplegia-epilepsy syndrome.
Tenney JR, Schapiro MB
Neurology 2012 Jul 3;79(1):e1-4. doi: 10.1212/WNL.0b013e31825dce5f. PMID: 22753451

Clinical prediction guides

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Multimodal nocturnal seizure detection in children with epilepsy: A prospective, multicenter, long-term, in-home trial.
van Westrhenen A, Lazeron RHC, van Dijk JP, Leijten FSS, Thijs RD; Dutch TeleEpilepsy Consortium
Epilepsia 2023 Aug;64(8):2137-2152. Epub 2023 Jun 14 doi: 10.1111/epi.17654. PMID: 37195144
Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE).
Demarest S, Jeste S, Agarwal N, Arkilo D, Asgharnejad M, Hsiao S, Thibert R
Epilepsy Behav 2023 May;142:109173. Epub 2023 Apr 1 doi: 10.1016/j.yebeh.2023.109173. PMID: 37011526
Intercorrelation of physiological seizure parameters and hormonal changes in electroconvulsive therapy.
Thörnblom E, Gingnell M, Cunningham JL, Landén M, Bodén R
Nord J Psychiatry 2023 Apr;77(3):312-318. Epub 2022 Aug 15 doi: 10.1080/08039488.2022.2107237. PMID: 35968653
Generalized nonmotor (absence) seizures-What do absence, generalized, and nonmotor mean?
Unterberger I, Trinka E, Kaplan PW, Walser G, Luef G, Bauer G
Epilepsia 2018 Mar;59(3):523-529. Epub 2018 Jan 11 doi: 10.1111/epi.13996. PMID: 29327337

Recent systematic reviews

Evaluation of Etomidate for Seizure Duration in Electroconvulsive Therapy: A Systematic Review and Meta-analysis.
Singh PM, Arora S, Borle A, Varma P, Trikha A, Goudra BG
J ECT 2015 Dec;31(4):213-25. doi: 10.1097/YCT.0000000000000212. PMID: 25634566
Effects of general anesthetic agents in adults receiving electroconvulsive therapy: a systematic review.
Hooten WM, Rasmussen KG Jr
J ECT 2008 Sep;24(3):208-23. doi: 10.1097/YCT.0b013e31815bfe2a. PMID: 18628717

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