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Anal canal carcinoma in situ

MedGen UID:
1615824
•Concept ID:
C4521060
•
Neoplastic Process
Synonyms: Anal Canal Carcinoma in situ; anal canal carcinoma in situ; anal canal in situ carcinoma; anal carcinoma in situ; anal carcinoma stage 0; anal intraepithelial neoplasia grade III; carcinoma in situ of anal canal; carcinoma in situ of anus; Stage 0 Anal Canal Cancer; stage 0 anal canal cancer; Stage 0 Anal Canal Cancer AJCC v6; stage 0 anal canal cancer aJCC v6; Stage 0 Anal Canal Cancer AJCC v6 and v7; stage 0 anal canal cancer aJCC v6 and v7; Stage 0 Anal Canal Cancer AJCC v7; stage 0 anal canal cancer aJCC v7; stage 0 anal canal carcinoma; Stage 0 Anal Canal Carcinoma AJCC v6 and v7; stage 0 anal canal carcinoma aJCC v6 and v7; Stage 0 Anal Carcinoma AJCC v6 and v7; stage 0 anal carcinoma aJCC v6 and v7; stage 0 anal carcinoma in situ
 
Monarch Initiative: MONDO:0004707

Definition

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th Eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal canal carcinoma in situ

Recent clinical studies

Etiology

Basaloid Squamous Cell Carcinoma of the Anus Revisited.
Graham RP, Arnold CA, Naini BV, Lam-Himlin DM
Am J Surg Pathol 2016 Mar;40(3):354-60. doi: 10.1097/PAS.0000000000000594. PMID: 26866355
The prognostic value of HPV status and p16 expression in patients with carcinoma of the anal canal.
Roldán Urgoiti GB, Gustafson K, Klimowicz AC, Petrillo SK, Magliocco AM, Doll CM
PLoS One 2014;9(10):e108790. Epub 2014 Oct 1 doi: 10.1371/journal.pone.0108790. PMID: 25271758Free PMC Article
Changing patterns of anal canal carcinoma in the United States.
Nelson RA, Levine AM, Bernstein L, Smith DD, Lai LL
J Clin Oncol 2013 Apr 20;31(12):1569-75. Epub 2013 Mar 18 doi: 10.1200/JCO.2012.45.2524. PMID: 23509304Free PMC Article
Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy.
Ortholan C, Ramaioli A, Peiffert D, Lusinchi A, Romestaing P, Chauveinc L, Touboul E, Peignaux K, Bruna A, de La Roche G, Lagrange JL, Alzieu C, Gerard JP
Int J Radiat Oncol Biol Phys 2005 Jun 1;62(2):479-85. doi: 10.1016/j.ijrobp.2004.09.060. PMID: 15890590

Diagnosis

The prospect of endoscopic submucosal dissection for early anal canal squamous cell carcinoma.
Ito T, Morita S, Shimeno N, Uehara K, Imai Y, Inokuma T
Clin J Gastroenterol 2016 Dec;9(6):384-388. Epub 2016 Oct 13 doi: 10.1007/s12328-016-0690-3. PMID: 27738909
Basaloid Squamous Cell Carcinoma of the Anus Revisited.
Graham RP, Arnold CA, Naini BV, Lam-Himlin DM
Am J Surg Pathol 2016 Mar;40(3):354-60. doi: 10.1097/PAS.0000000000000594. PMID: 26866355
Anal intraepithelial neoplasia in a sexually transmitted diseases outpatient clinic: correlation with cytological screening.
Repiso Jiménez JB, Frieyro-Elicegui M, Padilla-España L, Palma-Carazo F, de la Torre Lima J, Rivas-Ruiz F
J Eur Acad Dermatol Venereol 2014 May;28(5):658-61. Epub 2013 Mar 5 doi: 10.1111/jdv.12109. PMID: 23458493
Changing patterns of anal canal carcinoma in the United States.
Nelson RA, Levine AM, Bernstein L, Smith DD, Lai LL
J Clin Oncol 2013 Apr 20;31(12):1569-75. Epub 2013 Mar 18 doi: 10.1200/JCO.2012.45.2524. PMID: 23509304Free PMC Article
The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget's disease.
Ohnishi T, Watanabe S
Br J Dermatol 2000 Feb;142(2):243-7. doi: 10.1046/j.1365-2133.2000.03291.x. PMID: 10730755

Therapy

Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584

Prognosis

The prognostic value of HPV status and p16 expression in patients with carcinoma of the anal canal.
Roldán Urgoiti GB, Gustafson K, Klimowicz AC, Petrillo SK, Magliocco AM, Doll CM
PLoS One 2014;9(10):e108790. Epub 2014 Oct 1 doi: 10.1371/journal.pone.0108790. PMID: 25271758Free PMC Article
Changing patterns of anal canal carcinoma in the United States.
Nelson RA, Levine AM, Bernstein L, Smith DD, Lai LL
J Clin Oncol 2013 Apr 20;31(12):1569-75. Epub 2013 Mar 18 doi: 10.1200/JCO.2012.45.2524. PMID: 23509304Free PMC Article
Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy.
Ortholan C, Ramaioli A, Peiffert D, Lusinchi A, Romestaing P, Chauveinc L, Touboul E, Peignaux K, Bruna A, de La Roche G, Lagrange JL, Alzieu C, Gerard JP
Int J Radiat Oncol Biol Phys 2005 Jun 1;62(2):479-85. doi: 10.1016/j.ijrobp.2004.09.060. PMID: 15890590
The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget's disease.
Ohnishi T, Watanabe S
Br J Dermatol 2000 Feb;142(2):243-7. doi: 10.1046/j.1365-2133.2000.03291.x. PMID: 10730755

Clinical prediction guides

The prognostic value of HPV status and p16 expression in patients with carcinoma of the anal canal.
Roldán Urgoiti GB, Gustafson K, Klimowicz AC, Petrillo SK, Magliocco AM, Doll CM
PLoS One 2014;9(10):e108790. Epub 2014 Oct 1 doi: 10.1371/journal.pone.0108790. PMID: 25271758Free PMC Article
Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U; German Competence Network HIV/AIDS
Br J Dermatol 2010 Jun;162(6):1269-77. Epub 2010 Feb 22 doi: 10.1111/j.1365-2133.2010.09712.x. PMID: 20184584
The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extramammary Paget's disease.
Ohnishi T, Watanabe S
Br J Dermatol 2000 Feb;142(2):243-7. doi: 10.1046/j.1365-2133.2000.03291.x. PMID: 10730755

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