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Reduced T cell CD40 expression

MedGen UID:
1625346
Concept ID:
C4531163
Finding
HPO: HP:0031384

Definition

A deficiency in the expression of the CD40 ligand on the surface of activated T-lymphocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced T cell CD40 expression

Professional guidelines

PubMed

Mazzola MA, Raheja R, Regev K, Beynon V, von Glehn F, Paul A, Pierre I, Kivisakk P, Weiner HL, Gandhi R
Mult Scler 2019 Jan;25(1):63-71. Epub 2017 Nov 6 doi: 10.1177/1352458517740213. PMID: 29106333
Tung CH, Lu MC, Lai NS, Wu SF
PLoS One 2017;12(8):e0183726. Epub 2017 Aug 24 doi: 10.1371/journal.pone.0183726. PMID: 28837666Free PMC Article
Ding Q, Si X, Liu D, Peng J, Tang H, Sun W, Rui M, Chen Q, Wu L, Xu Y
J Control Release 2015 Jun 10;207:86-92. Epub 2015 Apr 1 doi: 10.1016/j.jconrel.2015.03.035. PMID: 25839125

Recent clinical studies

Etiology

Keller B, Strohmeier V, Harder I, Unger S, Payne KJ, Andrieux G, Boerries M, Felixberger PT, Landry JJM, Nieters A, Rensing-Ehl A, Salzer U, Frede N, Usadel S, Elling R, Speckmann C, Hainmann I, Ralph E, Gilmour K, Wentink MWJ, van der Burg M, Kuehn HS, Rosenzweig SD, Kölsch U, von Bernuth H, Kaiser-Labusch P, Gothe F, Hambleton S, Vlagea AD, Garcia Garcia A, Alsina L, Markelj G, Avcin T, Vasconcelos J, Guedes M, Ding JY, Ku CL, Shadur B, Avery DT, Venhoff N, Thiel J, Becker H, Erazo-Borrás L, Trujillo-Vargas CM, Franco JL, Fieschi C, Okada S, Gray PE, Uzel G, Casanova JL, Fliegauf M, Grimbacher B, Eibel H, Ehl S, Voll RE, Rizzi M, Stepensky P, Benes V, Ma CS, Bossen C, Tangye SG, Warnatz K
Sci Immunol 2021 Oct 15;6(64):eabh0891. Epub 2021 Oct 8 doi: 10.1126/sciimmunol.abh0891. PMID: 34623902
Garcia Cruz D, Giri RR, Gamiotea Turro D, Balsbaugh JL, Adler AJ, Rodriguez A
J Immunol 2021 Nov 1;207(9):2374-2384. Epub 2021 Sep 29 doi: 10.4049/jimmunol.2001188. PMID: 34588222Free PMC Article
Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T
Cancer Cell 2021 Jul 12;39(7):973-988.e9. Epub 2021 Jun 10 doi: 10.1016/j.ccell.2021.05.006. PMID: 34115989Free PMC Article
Nelke J, Medler J, Weisenberger D, Beilhack A, Wajant H
MAbs 2020 Jan-Dec;12(1):1807721. doi: 10.1080/19420862.2020.1807721. PMID: 32840410Free PMC Article
Kor DJ, Van Buskirk CM, Gajic O
Bosn J Basic Med Sci 2009 Oct;9 Suppl 1(Suppl 1):S21-S27. doi: 10.17305/bjbms.2009.2750. PMID: 19912115Free PMC Article

Diagnosis

Wang L, Sun J
Genes (Basel) 2022 Jul 28;13(8) doi: 10.3390/genes13081352. PMID: 36011263Free PMC Article
Zhao G, Liang J, Cao J, Jiang S, Lu J, Jiang B
J Healthc Eng 2022;2022:3724033. Epub 2022 Apr 19 doi: 10.1155/2022/3724033. PMID: 35494526Free PMC Article
Wiedemann A, Lettau M, Weißenberg SY, Stefanski AL, Schrezenmeier EV, Rincon-Arevalo H, Reiter K, Alexander T, Hiepe F, Lino AC, Dörner T
Front Immunol 2021;12:667991. Epub 2021 Apr 22 doi: 10.3389/fimmu.2021.667991. PMID: 33968071Free PMC Article
Galea R, Nel HJ, Talekar M, Liu X, Ooi JD, Huynh M, Hadjigol S, Robson KJ, Ting YT, Cole S, Cochlin K, Hitchcock S, Zeng B, Yekollu S, Boks M, Goh N, Roberts H, Rossjohn J, Reid HH, Boyd BJ, Malaviya R, Shealy DJ, Baker DG, Madakamutil L, Kitching AR, O'Sullivan BJ, Thomas R
JCI Insight 2019 Sep 19;4(18) doi: 10.1172/jci.insight.126025. PMID: 31487265Free PMC Article
Herrero C, Pérez-Simón JA
Braz J Med Biol Res 2010 May;43(5):425-30. Epub 2010 Apr 23 doi: 10.1590/s0100-879x2010007500033. PMID: 20490429

Therapy

Wang N, Chen Z, Zhang F, Zhang Q, Sun L, Lv H, Wang B, Shen J, Zhou X, Chen F, Zhang B, Meng L, Zhou H, Bai Z, Huang J
Front Immunol 2022;13:802690. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.802690. PMID: 35222381Free PMC Article
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y
Nat Commun 2021 Jun 8;12(1):3424. doi: 10.1038/s41467-021-23832-3. PMID: 34103524Free PMC Article
Bertelli R, Bonanni A, Di Donato A, Cioni M, Ravani P, Ghiggeri GM
Clin Exp Immunol 2016 Feb;183(2):166-74. Epub 2015 Oct 12 doi: 10.1111/cei.12675. PMID: 26147676Free PMC Article
Kor DJ, Van Buskirk CM, Gajic O
Bosn J Basic Med Sci 2009 Oct;9 Suppl 1(Suppl 1):S21-S27. doi: 10.17305/bjbms.2009.2750. PMID: 19912115Free PMC Article
Masri MA
Mol Immunol 2003 Jul;39(17-18):1073-7. doi: 10.1016/s0161-5890(03)00075-0. PMID: 12835079

Prognosis

Dhanasekaran R, Hansen AS, Park J, Lemaitre L, Lai I, Adeniji N, Kuruvilla S, Suresh A, Zhang J, Swamy V, Felsher DW
Cancer Res 2023 Feb 15;83(4):626-640. doi: 10.1158/0008-5472.CAN-22-0232. PMID: 36525476Free PMC Article
Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T
Cancer Cell 2021 Jul 12;39(7):973-988.e9. Epub 2021 Jun 10 doi: 10.1016/j.ccell.2021.05.006. PMID: 34115989Free PMC Article
Ragusa S, Prat-Luri B, González-Loyola A, Nassiri S, Squadrito ML, Guichard A, Cavin S, Gjorevski N, Barras D, Marra G, Lutolf MP, Perentes J, Corse E, Bianchi R, Wetterwald L, Kim J, Oliver G, Delorenzi M, De Palma M, Petrova TV
J Clin Invest 2020 Mar 2;130(3):1199-1216. doi: 10.1172/JCI129558. PMID: 32015230Free PMC Article
Raffray L, Burton RJ, Baker SE, Morgan MP, Eberl M
Immunology 2020 Jan;159(1):88-95. Epub 2019 Nov 21 doi: 10.1111/imm.13132. PMID: 31606902Free PMC Article
Vitaliti G, Leonardi S, Miraglia Del Giudice M, Salpietro A, Artusio L, Caimmi D, Arrigo T, Salpietro C, Ciprandi G, La Rosa M
J Biol Regul Homeost Agents 2012 Jan-Mar;26(1 Suppl):S85-93. PMID: 22691255

Clinical prediction guides

Xie X, Doody GM, Shuweihdi F, Conaghan PG, Ponchel F
Osteoarthritis Cartilage 2023 Sep;31(9):1176-1188. Epub 2023 Jun 7 doi: 10.1016/j.joca.2023.03.017. PMID: 37290499
Dhanasekaran R, Hansen AS, Park J, Lemaitre L, Lai I, Adeniji N, Kuruvilla S, Suresh A, Zhang J, Swamy V, Felsher DW
Cancer Res 2023 Feb 15;83(4):626-640. doi: 10.1158/0008-5472.CAN-22-0232. PMID: 36525476Free PMC Article
Lee HS, Jeong GS
Molecules 2020 Oct 8;25(19) doi: 10.3390/molecules25194590. PMID: 33050076Free PMC Article
Nelke J, Medler J, Weisenberger D, Beilhack A, Wajant H
MAbs 2020 Jan-Dec;12(1):1807721. doi: 10.1080/19420862.2020.1807721. PMID: 32840410Free PMC Article
Du X, Tang W, Chen X, Zeng T, Wang Y, Chen Z, Xu T, Zhou L, Tang X, An Y, Zhao X
Scand J Immunol 2019 Oct;90(4):e12798. Epub 2019 Jul 21 doi: 10.1111/sji.12798. PMID: 31179555

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