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Abnormal lymphocyte surface marker expression

MedGen UID:
1627791
•Concept ID:
C4531164
•
Finding
HPO: HP:0031383

Definition

Abnormal amount of a protein that is normally present on the cell surface of lymphocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal lymphocyte surface marker expression

Professional guidelines

PubMed

Flow Cytometric Evaluation of Surface and Cytoplasmic TRBC1 Expression in the Differential Diagnosis of Immature T-Cell Proliferations.
Horna P, Otteson GE, Shi M, Jevremovic D, Yuan J, Olteanu H
Am J Clin Pathol 2022 Jan 6;157(1):64-72. doi: 10.1093/ajcp/aqab098. PMID: 34302330
Flow cytometry immunophenotyping in integrated diagnostics of patients with newly diagnosed cytopenia: one tube 10-color 14-antibody screening panel and 3-tube extensive panel for detection of MDS-related features.
Porwit A, Rajab A
Int J Lab Hematol 2015 May;37 Suppl 1:133-43. doi: 10.1111/ijlh.12368. PMID: 25976971
Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment.
Ahearne MJ, Allchin RL, Fox CP, Wagner SD
Br J Haematol 2014 Aug;166(3):326-35. Epub 2014 May 12 doi: 10.1111/bjh.12941. PMID: 24815671

Recent clinical studies

Etiology

Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.
Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425Free PMC Article
The clinical significance of CD49e and CD56 for multiple myeloma in the novel agents era.
Okura M, Ida N, Yamauchi T
Med Oncol 2020 Oct 17;37(11):103. doi: 10.1007/s12032-020-01423-4. PMID: 33068194
Persistent Hyperactivation of Endothelial Cells in Patients with Alcoholic Hepatitis.
Xia Y, Yang J, Sanyal AJ, Shah VH, Chalasani NP, Yu Q, Zheng X, Li W
Alcohol Clin Exp Res 2020 May;44(5):1075-1087. Epub 2020 Apr 21 doi: 10.1111/acer.14331. PMID: 32246771Free PMC Article
Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.
D'Avola A, Drennan S, Tracy I, Henderson I, Chiecchio L, Larrayoz M, Rose-Zerilli M, Strefford J, Plass C, Johnson PW, Steele AJ, Packham G, Stevenson FK, Oakes CC, Forconi F
Blood 2016 Aug 11;128(6):816-26. Epub 2016 Jun 14 doi: 10.1182/blood-2016-03-707786. PMID: 27301861
Multiple myeloma and chronic lymphocytic leukemia.
Rosen L, Vescio R, Berenson JR
Curr Opin Hematol 1995 Jul;2(4):275-82. doi: 10.1097/00062752-199502040-00007. PMID: 9372008

Diagnosis

Aberrant expression of T cell activation markers and upregulation of Tregs in bone marrow and peripheral blood in acute myeloid leukemia patients.
Fang J, Zhang R, Lin X, Xu Y, Huang K, Saw PE
Hematology 2023 Dec;28(1):2219554. doi: 10.1080/16078454.2023.2219554. PMID: 37288810
Flow Cytometric Evaluation of Surface and Cytoplasmic TRBC1 Expression in the Differential Diagnosis of Immature T-Cell Proliferations.
Horna P, Otteson GE, Shi M, Jevremovic D, Yuan J, Olteanu H
Am J Clin Pathol 2022 Jan 6;157(1):64-72. doi: 10.1093/ajcp/aqab098. PMID: 34302330
Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.
Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425Free PMC Article
Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment.
Ahearne MJ, Allchin RL, Fox CP, Wagner SD
Br J Haematol 2014 Aug;166(3):326-35. Epub 2014 May 12 doi: 10.1111/bjh.12941. PMID: 24815671
How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype.
Crispín JC, Kyttaris VC, Juang YT, Tsokos GC
Trends Immunol 2008 Mar;29(3):110-5. Epub 2008 Feb 4 doi: 10.1016/j.it.2007.12.003. PMID: 18249583

Therapy

The clinical significance of CD49e and CD56 for multiple myeloma in the novel agents era.
Okura M, Ida N, Yamauchi T
Med Oncol 2020 Oct 17;37(11):103. doi: 10.1007/s12032-020-01423-4. PMID: 33068194
Immunometabolic and Lipidomic Markers Associated With the Frailty Index and Quality of Life in Aging HIV+ Men on Antiretroviral Therapy.
Yeoh HL, Cheng AC, Cherry CL, Weir JM, Meikle PJ, Hoy JF, Crowe SM, Palmer CS
EBioMedicine 2017 Aug;22:112-121. Epub 2017 Jul 18 doi: 10.1016/j.ebiom.2017.07.015. PMID: 28754302Free PMC Article
Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment.
Ahearne MJ, Allchin RL, Fox CP, Wagner SD
Br J Haematol 2014 Aug;166(3):326-35. Epub 2014 May 12 doi: 10.1111/bjh.12941. PMID: 24815671
Leukocyte perturbation associated with Fabry disease.
Rozenfeld P, Agriello E, De Francesco N, Martinez P, Fossati C
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S67-77. Epub 2009 Mar 7 doi: 10.1007/s10545-009-1060-9. PMID: 19259782
Multiple myeloma and chronic lymphocytic leukemia.
Rosen L, Vescio R, Berenson JR
Curr Opin Hematol 1995 Jul;2(4):275-82. doi: 10.1097/00062752-199502040-00007. PMID: 9372008

Prognosis

Aberrant expression of T cell activation markers and upregulation of Tregs in bone marrow and peripheral blood in acute myeloid leukemia patients.
Fang J, Zhang R, Lin X, Xu Y, Huang K, Saw PE
Hematology 2023 Dec;28(1):2219554. doi: 10.1080/16078454.2023.2219554. PMID: 37288810
CD160 receptor in CLL: Current state and future avenues.
Oumeslakht L, Aziz AI, Bensussan A, Ben Mkaddem S
Front Immunol 2022;13:1028013. Epub 2022 Nov 7 doi: 10.3389/fimmu.2022.1028013. PMID: 36420268Free PMC Article
CD markers variations in chronic lymphocytic leukemia: New insights into prognosis.
Vosoughi T, Bagheri M, Hosseinzadeh M, Ehsanpour A, Davari N, Saki N
J Cell Physiol 2019 Nov;234(11):19420-19439. Epub 2019 May 2 doi: 10.1002/jcp.28724. PMID: 31049958
Expression of CD markers' in immune thrombocytopenic purpura: prognostic approaches.
Behzad MM, Asnafi AA, Jaseb K, Jalali Far MA, Saki N
APMIS 2017 Dec;125(12):1042-1055. Epub 2017 Sep 28 doi: 10.1111/apm.12755. PMID: 28960510
Identification of regulatory T cells in systemic lupus erythematosus.
Gerli R, Nocentini G, Alunno A, Bocci EB, Bianchini R, Bistoni O, Riccardi C
Autoimmun Rev 2009 Mar;8(5):426-30. Epub 2009 Feb 8 doi: 10.1016/j.autrev.2009.01.004. PMID: 19185065

Clinical prediction guides

Impaired surface marker expression in stimulated Epstein-Barr virus transformed lymphoblasts from Barth Syndrome patients.
Zegallai HM, Hatch GM
Sci Rep 2022 Apr 13;12(1):6195. doi: 10.1038/s41598-022-10270-4. PMID: 35418665Free PMC Article
Comprehensive Overview of Gene Rearrangements in Childhood T-Cell Acute Lymphoblastic Leukaemia.
Mroczek A, Zawitkowska J, Kowalczyk J, Lejman M
Int J Mol Sci 2021 Jan 15;22(2) doi: 10.3390/ijms22020808. PMID: 33467425Free PMC Article
Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.
D'Avola A, Drennan S, Tracy I, Henderson I, Chiecchio L, Larrayoz M, Rose-Zerilli M, Strefford J, Plass C, Johnson PW, Steele AJ, Packham G, Stevenson FK, Oakes CC, Forconi F
Blood 2016 Aug 11;128(6):816-26. Epub 2016 Jun 14 doi: 10.1182/blood-2016-03-707786. PMID: 27301861
Morphological and immunophenotypic features of chronic lymphocytic leukemia.
Matutes E, Polliack A
Rev Clin Exp Hematol 2000 Mar;4(1):22-47. doi: 10.1046/j.1468-0734.2000.00002.x. PMID: 11486329
Biology of the neoplastic lymphocyte in B-CLL.
Dighiero G
Baillieres Clin Haematol 1993 Dec;6(4):807-20. doi: 10.1016/s0950-3536(05)80177-5. PMID: 8038491

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