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Refractory Acute Myeloid Leukemia

MedGen UID:
1627534
Concept ID:
C4528668
Neoplastic Process
Synonyms: Refractory acute myelocytic leukemia; Refractory acute myeloid leukemia; Refractory AML; Refractory AML (acute myelocytic leukemia); Refractory AML (acute myeloid leukemia)
SNOMED CT: Refractory AML (acute myelocytic leukemia) (12291000132102); Refractory acute myelocytic leukemia (12291000132102); Refractory acute myeloid leukemia (12291000132102); Refractory AML (acute myeloid leukemia) (12291000132102)

Definition

Acute myeloid leukemia that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Duffy MJ, Synnott NC, O'Grady S, Crown J
Semin Cancer Biol 2022 Feb;79:58-67. Epub 2020 Jul 31 doi: 10.1016/j.semcancer.2020.07.005. PMID: 32741700
Duffy MJ, O'Grady S, Tang M, Crown J
Cancer Treat Rev 2021 Mar;94:102154. Epub 2021 Jan 19 doi: 10.1016/j.ctrv.2021.102154. PMID: 33524794
Bose P, Vachhani P, Cortes JE
Curr Treat Options Oncol 2017 Mar;18(3):17. doi: 10.1007/s11864-017-0456-2. PMID: 28286924

Recent clinical studies

Etiology

DeAngelo DJ, Jonas BA, Liesveld JL, Bixby DL, Advani AS, Marlton P, Magnani JL, Thackray HM, Feldman EJ, O'Dwyer ME, Becker PS
Blood 2022 Feb 24;139(8):1135-1146. doi: 10.1182/blood.2021010721. PMID: 34543383Free PMC Article
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A, Ravandi F, Erba HP, Byrne M, Michaelis L, Topp MS, Vey N, Ciceri F, Carrabba MG, Paolini S, Huls GA, Jongen-Lavrencic M, Wermke M, Chevallier P, Gyan E, Récher C, Stiff PJ, Pettit KM, Löwenberg B, Church SE, Anderson E, Vadakekolathu J, Santaguida M, Rettig MP, Muth J, Curtis T, Fehr E, Guo K, Zhao J, Bakkacha O, Jacobs K, Tran K, Kaminker P, Kostova M, Bonvini E, Walter RB, Davidson-Moncada JK, Rutella S, DiPersio JF
Blood 2021 Feb 11;137(6):751-762. doi: 10.1182/blood.2020007732. PMID: 32929488Free PMC Article
Perl AE, Martinelli G, Cortes JE, Neubauer A, Berman E, Paolini S, Montesinos P, Baer MR, Larson RA, Ustun C, Fabbiano F, Erba HP, Di Stasi A, Stuart R, Olin R, Kasner M, Ciceri F, Chou WC, Podoltsev N, Recher C, Yokoyama H, Hosono N, Yoon SS, Lee JH, Pardee T, Fathi AT, Liu C, Hasabou N, Liu X, Bahceci E, Levis MJ
N Engl J Med 2019 Oct 31;381(18):1728-1740. doi: 10.1056/NEJMoa1902688. PMID: 31665578
DiNardo CD, Rausch CR, Benton C, Kadia T, Jain N, Pemmaraju N, Daver N, Covert W, Marx KR, Mace M, Jabbour E, Cortes J, Garcia-Manero G, Ravandi F, Bhalla KN, Kantarjian H, Konopleva M
Am J Hematol 2018 Mar;93(3):401-407. Epub 2017 Dec 23 doi: 10.1002/ajh.25000. PMID: 29218851

Diagnosis

Li K, Du Y, Cai Y, Liu W, Lv Y, Huang B, Zhang L, Wang Z, Liu P, Sun Q, Li N, Zhu M, Bosco B, Li L, Wu W, Wu L, Li J, Wang Q, Hong M, Qian S
Leukemia 2023 Feb;37(2):308-325. Epub 2022 Dec 21 doi: 10.1038/s41375-022-01789-6. PMID: 36543880Free PMC Article
DeAngelo DJ, Jonas BA, Liesveld JL, Bixby DL, Advani AS, Marlton P, Magnani JL, Thackray HM, Feldman EJ, O'Dwyer ME, Becker PS
Blood 2022 Feb 24;139(8):1135-1146. doi: 10.1182/blood.2021010721. PMID: 34543383Free PMC Article
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Horibata S, Gui G, Lack J, DeStefano CB, Gottesman MM, Hourigan CS
Proc Natl Acad Sci U S A 2019 May 21;116(21):10494-10503. Epub 2019 May 7 doi: 10.1073/pnas.1902375116. PMID: 31064876Free PMC Article
Schlenk RF, Müller-Tidow C, Benner A, Kieser M
Curr Opin Oncol 2017 Nov;29(6):467-473. doi: 10.1097/CCO.0000000000000404. PMID: 28857842

Therapy

Daver N, Perl AE, Maly J, Levis M, Ritchie E, Litzow M, McCloskey J, Smith CC, Schiller G, Bradley T, Tiu RV, Naqvi K, Dail M, Brackman D, Siddani S, Wang J, Chyla B, Lee P, Altman JK
J Clin Oncol 2022 Dec 10;40(35):4048-4059. Epub 2022 Jul 18 doi: 10.1200/JCO.22.00602. PMID: 35849791Free PMC Article
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Duffy MJ, O'Grady S, Tang M, Crown J
Cancer Treat Rev 2021 Mar;94:102154. Epub 2021 Jan 19 doi: 10.1016/j.ctrv.2021.102154. PMID: 33524794
Perl AE, Martinelli G, Cortes JE, Neubauer A, Berman E, Paolini S, Montesinos P, Baer MR, Larson RA, Ustun C, Fabbiano F, Erba HP, Di Stasi A, Stuart R, Olin R, Kasner M, Ciceri F, Chou WC, Podoltsev N, Recher C, Yokoyama H, Hosono N, Yoon SS, Lee JH, Pardee T, Fathi AT, Liu C, Hasabou N, Liu X, Bahceci E, Levis MJ
N Engl J Med 2019 Oct 31;381(18):1728-1740. doi: 10.1056/NEJMoa1902688. PMID: 31665578
Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS
Blood 2017 Aug 10;130(6):722-731. Epub 2017 Jun 6 doi: 10.1182/blood-2017-04-779405. PMID: 28588020Free PMC Article

Prognosis

DeAngelo DJ, Jonas BA, Liesveld JL, Bixby DL, Advani AS, Marlton P, Magnani JL, Thackray HM, Feldman EJ, O'Dwyer ME, Becker PS
Blood 2022 Feb 24;139(8):1135-1146. doi: 10.1182/blood.2021010721. PMID: 34543383Free PMC Article
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A, Ravandi F, Erba HP, Byrne M, Michaelis L, Topp MS, Vey N, Ciceri F, Carrabba MG, Paolini S, Huls GA, Jongen-Lavrencic M, Wermke M, Chevallier P, Gyan E, Récher C, Stiff PJ, Pettit KM, Löwenberg B, Church SE, Anderson E, Vadakekolathu J, Santaguida M, Rettig MP, Muth J, Curtis T, Fehr E, Guo K, Zhao J, Bakkacha O, Jacobs K, Tran K, Kaminker P, Kostova M, Bonvini E, Walter RB, Davidson-Moncada JK, Rutella S, DiPersio JF
Blood 2021 Feb 11;137(6):751-762. doi: 10.1182/blood.2020007732. PMID: 32929488Free PMC Article
Perl AE, Martinelli G, Cortes JE, Neubauer A, Berman E, Paolini S, Montesinos P, Baer MR, Larson RA, Ustun C, Fabbiano F, Erba HP, Di Stasi A, Stuart R, Olin R, Kasner M, Ciceri F, Chou WC, Podoltsev N, Recher C, Yokoyama H, Hosono N, Yoon SS, Lee JH, Pardee T, Fathi AT, Liu C, Hasabou N, Liu X, Bahceci E, Levis MJ
N Engl J Med 2019 Oct 31;381(18):1728-1740. doi: 10.1056/NEJMoa1902688. PMID: 31665578
Schlenk RF, Müller-Tidow C, Benner A, Kieser M
Curr Opin Oncol 2017 Nov;29(6):467-473. doi: 10.1097/CCO.0000000000000404. PMID: 28857842

Clinical prediction guides

Smith CC, Levis MJ, Perl AE, Hill JE, Rosales M, Bahceci E
Blood Adv 2022 Apr 12;6(7):2144-2155. doi: 10.1182/bloodadvances.2021006489. PMID: 35130342Free PMC Article
DeAngelo DJ, Jonas BA, Liesveld JL, Bixby DL, Advani AS, Marlton P, Magnani JL, Thackray HM, Feldman EJ, O'Dwyer ME, Becker PS
Blood 2022 Feb 24;139(8):1135-1146. doi: 10.1182/blood.2021010721. PMID: 34543383Free PMC Article
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A, Ravandi F, Erba HP, Byrne M, Michaelis L, Topp MS, Vey N, Ciceri F, Carrabba MG, Paolini S, Huls GA, Jongen-Lavrencic M, Wermke M, Chevallier P, Gyan E, Récher C, Stiff PJ, Pettit KM, Löwenberg B, Church SE, Anderson E, Vadakekolathu J, Santaguida M, Rettig MP, Muth J, Curtis T, Fehr E, Guo K, Zhao J, Bakkacha O, Jacobs K, Tran K, Kaminker P, Kostova M, Bonvini E, Walter RB, Davidson-Moncada JK, Rutella S, DiPersio JF
Blood 2021 Feb 11;137(6):751-762. doi: 10.1182/blood.2020007732. PMID: 32929488Free PMC Article
DiNardo CD, Rausch CR, Benton C, Kadia T, Jain N, Pemmaraju N, Daver N, Covert W, Marx KR, Mace M, Jabbour E, Cortes J, Garcia-Manero G, Ravandi F, Bhalla KN, Kantarjian H, Konopleva M
Am J Hematol 2018 Mar;93(3):401-407. Epub 2017 Dec 23 doi: 10.1002/ajh.25000. PMID: 29218851
Schlenk RF, Müller-Tidow C, Benner A, Kieser M
Curr Opin Oncol 2017 Nov;29(6):467-473. doi: 10.1097/CCO.0000000000000404. PMID: 28857842

Recent systematic reviews

Cao S, Tao Q, Wang J, Zhang Q, Dong Y
Medicine (Baltimore) 2023 Nov 3;102(44):e34949. doi: 10.1097/MD.0000000000034949. PMID: 37933074Free PMC Article
Shahzad M, Nguyen A, Hussain A, Ammad-Ud-Din M, Faisal MS, Tariq E, Ali F, Butt A, Anwar I, Chaudhary SG, Lutfi F, Ahmed N, Singh AK, Hematti P, McGuirk JP, Mushtaq MU
Front Immunol 2023;14:1152457. Epub 2023 Apr 24 doi: 10.3389/fimmu.2023.1152457. PMID: 37168849Free PMC Article
Zhang D, Chen J
Medicine (Baltimore) 2022 Sep 16;101(37):e30644. doi: 10.1097/MD.0000000000030644. PMID: 36123842Free PMC Article
Russell-Smith TA, Gurskyte L, Muresan B, Mamolo CM, Gezin A, Cappelleri JC, Heeg B
Future Oncol 2022 May;18(16):2029-2039. Epub 2022 Feb 24 doi: 10.2217/fon-2021-1355. PMID: 35196866
Megías-Vericat JE, Martínez-Cuadrón D, Sanz MÁ, Montesinos P
Ann Hematol 2018 Jul;97(7):1115-1153. Epub 2018 Apr 21 doi: 10.1007/s00277-018-3304-y. PMID: 29680875

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