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Locally Advanced Unresectable Renal Cell Carcinoma

MedGen UID:
1650694
•Concept ID:
C4744334
•
Neoplastic Process

Definition

A renal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Renal Cell Carcinoma

Professional guidelines

PubMed

Reasons for lack of treatment in patients with locally advanced, unresectable or metastatic urothelial carcinoma.
Omland LH, Joensen UN, Toft BG, Lund CM, Lindberg H, Knudsen MB, Tolver A, Suetta C, Pappot H
Acta Oncol 2022 Sep;61(9):1036-1042. Epub 2022 Aug 25 doi: 10.1080/0284186X.2022.2114378. PMID: 36017555
Treatment strategies for advanced renal cell carcinoma: A new paradigm for surgical treatment.
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163
Clinical presentation and management of hand-foot skin reaction associated with sorafenib in combination with cytotoxic chemotherapy: experience in breast cancer.
Gomez P, Lacouture ME
Oncologist 2011;16(11):1508-19. Epub 2011 Oct 20 doi: 10.1634/theoncologist.2011-0115. PMID: 22016478Free PMC Article

Recent clinical studies

Etiology

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study.
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Treatment strategies for advanced renal cell carcinoma: A new paradigm for surgical treatment.
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163

Diagnosis

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Reasons for lack of treatment in patients with locally advanced, unresectable or metastatic urothelial carcinoma.
Omland LH, Joensen UN, Toft BG, Lund CM, Lindberg H, Knudsen MB, Tolver A, Suetta C, Pappot H
Acta Oncol 2022 Sep;61(9):1036-1042. Epub 2022 Aug 25 doi: 10.1080/0284186X.2022.2114378. PMID: 36017555
CaboPoint: a phase II study of cabozantinib as second-line treatment in patients with metastatic renal cell carcinoma.
Albiges L, Schmidinger M, Taguieva-Pioger N, Perol D, Grünwald V, Guemas E
Future Oncol 2022 Mar;18(8):915-926. Epub 2021 Dec 16 doi: 10.2217/fon-2021-1006. PMID: 34911359
Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.
Nakahara S, Takenaka Y, Ogawa K, Nishiike S, Yamamoto Y, Seo Y, Isohashi F, Suzuki O, Yoshioka Y, Sumida I, Yoshii T, Tomiyama Y, Inohara H
Int J Clin Oncol 2016 Dec;21(6):1030-1037. Epub 2016 Jun 15 doi: 10.1007/s10147-016-0997-6. PMID: 27306220
Chemoradiation for locally advanced squamous cell carcinoma of the head and neck for organ preservation and palliation.
Poole ME, Sailer SL, Rosenman JG, Tepper JE, Weissler MC, Shockley WW, Yarbrough WG, Pillsbury HC 3rd, Schell MJ, Bernard SA
Arch Otolaryngol Head Neck Surg 2001 Dec;127(12):1446-50. doi: 10.1001/archotol.127.12.1446. PMID: 11735812

Therapy

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Lenvatinib-related renal microangiopathy: a case series.
Delsante M, Monroy-Trujillo JM, Carter-Monroe N, Ball DW, Rosenberg AZ
Virchows Arch 2022 Feb;480(2):467-473. Epub 2021 May 6 doi: 10.1007/s00428-021-03114-5. PMID: 33959820
Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study.
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Treatment strategies for advanced renal cell carcinoma: A new paradigm for surgical treatment.
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163

Prognosis

First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study.
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Treatment strategies for advanced renal cell carcinoma: A new paradigm for surgical treatment.
Tomita Y
Int J Urol 2016 Jan;23(1):13-21. Epub 2015 Sep 7 doi: 10.1111/iju.12899. PMID: 26347163
Computed tomography characteristics of unresectable primary renal cell carcinoma treated with neoadjuvant sunitinib.
Salem ME, Shah SN, Elson P, Garcia JA, Wood LS, Medsinge A, Campbell S, Dreicer R, Rini BI
Clin Genitourin Cancer 2014 Apr;12(2):117-23. Epub 2013 Oct 12 doi: 10.1016/j.clgc.2013.08.001. PMID: 24126239
Predicting cancer-control outcomes in patients with renal cell carcinoma.
Karakiewicz PI, Hutterer GC
Curr Opin Urol 2007 Sep;17(5):295-302. doi: 10.1097/MOU.0b013e3282a4a6b7. PMID: 17762620
Chemoradiation for locally advanced squamous cell carcinoma of the head and neck for organ preservation and palliation.
Poole ME, Sailer SL, Rosenman JG, Tepper JE, Weissler MC, Shockley WW, Yarbrough WG, Pillsbury HC 3rd, Schell MJ, Bernard SA
Arch Otolaryngol Head Neck Surg 2001 Dec;127(12):1446-50. doi: 10.1001/archotol.127.12.1446. PMID: 11735812

Clinical prediction guides

Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.
Grimm MO, Grün CB, Niegisch G, Pichler M, Roghmann F, Schmitz-Dräger B, Baretton G, Schmitz M, Bolenz C, Foller S, Leucht K, Schumacher U, Schostak M, Meran J, Loidl W, Zengerling F
Lancet Oncol 2023 Apr;24(4):347-359. Epub 2023 Feb 28 doi: 10.1016/S1470-2045(23)00053-0. PMID: 36868252
Efficacy and feasibility of induction chemotherapy with paclitaxel, carboplatin and cetuximab for locally advanced unresectable head and neck cancer patients ineligible for combination treatment with docetaxel, cisplatin, and 5-fluorouracil.
Shirasu H, Yokota T, Kawakami T, Hamauchi S, Onozawa Y, Ogawa H, Onoe T, Mori K, Onitsuka T
Int J Clin Oncol 2020 Nov;25(11):1914-1920. Epub 2020 Jul 9 doi: 10.1007/s10147-020-01742-6. PMID: 32648132
First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study.
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485
Computed tomography characteristics of unresectable primary renal cell carcinoma treated with neoadjuvant sunitinib.
Salem ME, Shah SN, Elson P, Garcia JA, Wood LS, Medsinge A, Campbell S, Dreicer R, Rini BI
Clin Genitourin Cancer 2014 Apr;12(2):117-23. Epub 2013 Oct 12 doi: 10.1016/j.clgc.2013.08.001. PMID: 24126239
Predicting cancer-control outcomes in patients with renal cell carcinoma.
Karakiewicz PI, Hutterer GC
Curr Opin Urol 2007 Sep;17(5):295-302. doi: 10.1097/MOU.0b013e3282a4a6b7. PMID: 17762620

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