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Locally Advanced Carcinoma

MedGen UID:
1665275
•Concept ID:
C4724834
•
Neoplastic Process

Definition

A carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Carcinoma

Professional guidelines

PubMed

Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article
American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy.
Viswanathan AN, Beriwal S, De Los Santos JF, Demanes DJ, Gaffney D, Hansen J, Jones E, Kirisits C, Thomadsen B, Erickson B; American Brachytherapy Society
Brachytherapy 2012 Jan-Feb;11(1):47-52. doi: 10.1016/j.brachy.2011.07.002. PMID: 22265437Free PMC Article

Recent clinical studies

Etiology

A New Survival Score for Patients Scheduled for Palliative Irradiation of Locally Advanced Carcinoma of the Head-and-Neck.
Rades D, Staackmann C, Ribbat-Idel J, Perner S, Idel C, Bruchhage KL, Hakim SG, Schild SE
Anticancer Res 2021 Jun;41(6):3055-3058. doi: 10.21873/anticanres.15088. PMID: 34083297
Patterns of Recurrence in Locally Advanced Resectable Oesophageal Carcinoma: Retrospective Review from a Tertiary Cancer Centre in South India.
Das A, Surendran S, Mathew M, Irodi A, Singh A, Joel A, Yacob M, Isiah R, Samarasam I, John S, Pavamani S, Sasidharan BK
J Gastrointest Cancer 2021 Jun;52(2):711-718. doi: 10.1007/s12029-020-00464-2. PMID: 32720121
Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article
Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD004329. doi: 10.1002/14651858.CD004329.pub2. PMID: 17054200Free PMC Article

Diagnosis

Prediction of response to radiotherapy in locally advanced carcinoma cervix using multiparametric MRI: A prospective, single-center, longitudinal study.
Verma A, Kumar I, Patel DS, Ranjan R, Singh M, Pradhan S, Shukla RC
Asia Pac J Clin Oncol 2023 Feb;19(1):79-86. Epub 2022 Apr 18 doi: 10.1111/ajco.13761. PMID: 35437940
Concurrent chemoradiation and brachytherapy alone or in combination with nelfinavir in locally advanced cervical cancer (NELCER): study protocol for a phase III trial.
Chopra S, Goda JS, Mittal P, Mulani J, Pant S, Pai V, Kannan S, Deodhar K, Krishnamurthy MN, Menon S, Charnalia M, Shah S, Rangarajan V, Gota V, Naidu L, Sawant S, Thakkar P, Popat P, Ghosh J, Rath S, Gulia S, Engineer R, Mahantshetty U, Gupta S
BMJ Open 2022 Apr 6;12(4):e055765. doi: 10.1136/bmjopen-2021-055765. PMID: 35387819Free PMC Article
Patterns of Recurrence in Locally Advanced Resectable Oesophageal Carcinoma: Retrospective Review from a Tertiary Cancer Centre in South India.
Das A, Surendran S, Mathew M, Irodi A, Singh A, Joel A, Yacob M, Isiah R, Samarasam I, John S, Pavamani S, Sasidharan BK
J Gastrointest Cancer 2021 Jun;52(2):711-718. doi: 10.1007/s12029-020-00464-2. PMID: 32720121
Management of Locally Advanced Carcinoma Oesophagus with Radiation/Chemoradiation: Single Institute Experience.
Kumaran D, John S, Isiah R, Das S
J Gastrointest Cancer 2016 Sep;47(3):313-7. doi: 10.1007/s12029-016-9825-5. PMID: 27146042
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article

Therapy

Patterns of Recurrence in Locally Advanced Resectable Oesophageal Carcinoma: Retrospective Review from a Tertiary Cancer Centre in South India.
Das A, Surendran S, Mathew M, Irodi A, Singh A, Joel A, Yacob M, Isiah R, Samarasam I, John S, Pavamani S, Sasidharan BK
J Gastrointest Cancer 2021 Jun;52(2):711-718. doi: 10.1007/s12029-020-00464-2. PMID: 32720121
Locally advanced cervical cancer - neoadjuvant chemotherapy followed by concurrent chemoradiation and targeted therapy as maintenance: A phase II study.
Benson R, Pathy S, Kumar L, Mathur S, Dadhwal V, Mohanti BK
J Cancer Res Ther 2019 Oct-Dec;15(6):1359-1364. doi: 10.4103/jcrt.JCRT_39_18. PMID: 31898673
Neoadjuvant treatment intensification or adjuvant chemotherapy for locally advanced carcinoma rectum: The optimum treatment approach remains unresolved.
Mallick S, Benson R, Haresh KP, Rath GK
J Egypt Natl Canc Inst 2015 Dec;27(4):179-85. Epub 2015 Jun 10 doi: 10.1016/j.jnci.2015.05.003. PMID: 26071798
Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD004329. doi: 10.1002/14651858.CD004329.pub2. PMID: 17054200Free PMC Article
Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva.
Eifel PJ, Morris M, Burke TW, Levenback C, Gershenson DM
Gynecol Oncol 1995 Oct;59(1):51-6. doi: 10.1006/gyno.1995.1267. PMID: 7557615

Prognosis

A New Survival Score for Patients Scheduled for Palliative Irradiation of Locally Advanced Carcinoma of the Head-and-Neck.
Rades D, Staackmann C, Ribbat-Idel J, Perner S, Idel C, Bruchhage KL, Hakim SG, Schild SE
Anticancer Res 2021 Jun;41(6):3055-3058. doi: 10.21873/anticanres.15088. PMID: 34083297
Patterns of Recurrence in Locally Advanced Resectable Oesophageal Carcinoma: Retrospective Review from a Tertiary Cancer Centre in South India.
Das A, Surendran S, Mathew M, Irodi A, Singh A, Joel A, Yacob M, Isiah R, Samarasam I, John S, Pavamani S, Sasidharan BK
J Gastrointest Cancer 2021 Jun;52(2):711-718. doi: 10.1007/s12029-020-00464-2. PMID: 32720121
DCE-MRI of locally-advanced carcinoma of the uterine cervix: Tofts analysis versus non-model-based analyses.
Lund KV, Simonsen TG, Kristensen GB, Rofstad EK
Radiat Oncol 2020 Apr 15;15(1):79. doi: 10.1186/s13014-020-01526-2. PMID: 32293487Free PMC Article
Neoadjuvant treatment intensification or adjuvant chemotherapy for locally advanced carcinoma rectum: The optimum treatment approach remains unresolved.
Mallick S, Benson R, Haresh KP, Rath GK
J Egypt Natl Canc Inst 2015 Dec;27(4):179-85. Epub 2015 Jun 10 doi: 10.1016/j.jnci.2015.05.003. PMID: 26071798
The epidemiology, diagnosis, and treatment of Barrett's carcinoma.
Labenz J, Koop H, Tannapfel A, Kiesslich R, Hölscher AH
Dtsch Arztebl Int 2015 Mar 27;112(13):224-33; quiz 234. doi: 10.3238/arztebl.2015.0224. PMID: 25869347Free PMC Article

Clinical prediction guides

A Comparative Study of Clinical Outcomes in Locally Advanced Cervical Cancer: External Beam Radiotherapy (EBRT) and Sequential High Dose Rate Intracavitary Brachytherapy (HDRICBT) with or without Concurrent Cisplatin on the Day of ICBT Insertion - A Tertiary Care Center Randomized Controlled Trial in India.
Alim S, Siddiqui SA, Akram M, Hakim S, Khan MA
Asian Pac J Cancer Prev 2024 Apr 1;25(4):1333-1338. doi: 10.31557/APJCP.2024.25.4.1333. PMID: 38679994
Prediction of response to radiotherapy in locally advanced carcinoma cervix using multiparametric MRI: A prospective, single-center, longitudinal study.
Verma A, Kumar I, Patel DS, Ranjan R, Singh M, Pradhan S, Shukla RC
Asia Pac J Clin Oncol 2023 Feb;19(1):79-86. Epub 2022 Apr 18 doi: 10.1111/ajco.13761. PMID: 35437940
A New Survival Score for Patients Scheduled for Palliative Irradiation of Locally Advanced Carcinoma of the Head-and-Neck.
Rades D, Staackmann C, Ribbat-Idel J, Perner S, Idel C, Bruchhage KL, Hakim SG, Schild SE
Anticancer Res 2021 Jun;41(6):3055-3058. doi: 10.21873/anticanres.15088. PMID: 34083297
To study the role of pre-treatment microRNA (micro ribonucleic acid) expression as a predictor of response to chemoradiation in locally advanced carcinoma cervix.
Barik S, Mitra S, Suryavanshi M, Dewan A, Kaur I, Kumar D, Mishra M, Vishwakarma G
Cancer Rep (Hoboken) 2021 Aug;4(4):e1348. Epub 2021 Mar 3 doi: 10.1002/cnr2.1348. PMID: 33660436Free PMC Article
Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD004329. doi: 10.1002/14651858.CD004329.pub2. PMID: 17054200Free PMC Article

Recent systematic reviews

Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma.
Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP; MAC-NPC Collaborative Group
Cochrane Database Syst Rev 2006 Oct 18;2006(4):CD004329. doi: 10.1002/14651858.CD004329.pub2. PMID: 17054200Free PMC Article

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