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Metastatic Urethral Carcinoma

MedGen UID:
1654675
•Concept ID:
C4727596
•
Neoplastic Process
Synonyms: Metastatic Carcinoma of the Urethra; Metastatic Carcinoma of Urethra

Definition

Urethral carcinoma that has spread to another anatomical site. [from NCI]

Professional guidelines

PubMed

An assessment of urethral radiation exposure in the treatment of endometrial and rectal cancers.
Hines K, Nieto K, Dezarn W, Greven K, Krol B, Matthews C, Parker-Autry C
Int Urogynecol J 2023 Apr;34(4):929-935. Epub 2022 Oct 1 doi: 10.1007/s00192-022-05363-7. PMID: 36181547
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
EAU guidelines on primary urethral carcinoma.
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479

Recent clinical studies

Etiology

Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.
Vassiliou V, Katsila T, Sodergren SC, Kardamakis D
Anticancer Res 2022 Aug;42(8):3767-3778. doi: 10.21873/anticanres.15867. PMID: 35896266
Robotic Urethral Reconstruction Outcomes in Men With Posterior Urethral Stenosis.
Bearrick EN, Findlay BL, Maciejko LA, Hebert KJ, Anderson KT, Viers BR
Urology 2022 Mar;161:118-124. Epub 2021 Dec 27 doi: 10.1016/j.urology.2021.11.035. PMID: 34968569
EAU guidelines on primary urethral carcinoma.
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Herpesvirus.
Baker DA
Clin Obstet Gynecol 1983 Mar;26(1):165-72. doi: 10.1097/00003081-198303000-00020. PMID: 6301717

Diagnosis

Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.
Vassiliou V, Katsila T, Sodergren SC, Kardamakis D
Anticancer Res 2022 Aug;42(8):3767-3778. doi: 10.21873/anticanres.15867. PMID: 35896266
Follow-up Management of Cystectomy Patients.
Reddy M, Kader K
Urol Clin North Am 2018 May;45(2):241-247. doi: 10.1016/j.ucl.2018.01.001. PMID: 29650139
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
Prepubertal vulvovaginopathies.
Pokorny SF
Obstet Gynecol Clin North Am 1992 Mar;19(1):39-58. PMID: 1584544
Herpesvirus.
Baker DA
Clin Obstet Gynecol 1983 Mar;26(1):165-72. doi: 10.1097/00003081-198303000-00020. PMID: 6301717

Therapy

Granular cell tumors of the urethra.
Evmorfopoulos K, Tzortzis V, Vlachostergios PJ
Cancer Treat Res Commun 2023;35:100695. Epub 2023 Mar 17 doi: 10.1016/j.ctarc.2023.100695. PMID: 36940531
Urethral recurrence after cystectomy: current preventative measures, diagnosis and management.
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
EAU guidelines on primary urethral carcinoma.
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Chemotherapy for penile and urethral carcinoma.
Trabulsi EJ, Hoffman-Censits J
Urol Clin North Am 2010 Aug;37(3):467-74. doi: 10.1016/j.ucl.2010.04.010. PMID: 20674701
Superficial bladder cancer therapy.
Schenkman E, Lamm DL
ScientificWorldJournal 2004 Jun 28;4 Suppl 1:387-99. doi: 10.1100/tsw.2004.81. PMID: 15349563Free PMC Article

Prognosis

Female urethral carcinoma: a contemporary review of the clinicopathologic features, with emphasis on the histoanatomic landmarks and potential staging issues.
Lagarde-Lenon MS, Aron M
Hum Pathol 2022 Nov;129:71-80. Epub 2022 Aug 28 doi: 10.1016/j.humpath.2022.08.003. PMID: 36037997
Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications.
Vassiliou V, Katsila T, Sodergren SC, Kardamakis D
Anticancer Res 2022 Aug;42(8):3767-3778. doi: 10.21873/anticanres.15867. PMID: 35896266
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
EAU guidelines on primary urethral carcinoma.
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Herpesvirus.
Baker DA
Clin Obstet Gynecol 1983 Mar;26(1):165-72. doi: 10.1097/00003081-198303000-00020. PMID: 6301717

Clinical prediction guides

Inverted urethral flap reconstruction after partial penectomy: Long-term oncological and functional outcomes.
Chavarriaga J, Becerra L, Camacho D, Godoy F, Forero J, Cabrera M, López-de-Mesa B, Ramirez A, Suso-Palau D, Varela R
Urol Oncol 2022 Apr;40(4):169.e13-169.e20. Epub 2022 Mar 6 doi: 10.1016/j.urolonc.2022.02.006. PMID: 35260297
Primary tumor surgery improves survival in non-metastatic primary urethral carcinoma patients: a large population-based investigation.
Wu J, Wang YC, Luo WJ, Bo-Dai, Ye DW, Zhu YP
BMC Cancer 2021 Jul 27;21(1):857. doi: 10.1186/s12885-021-08603-z. PMID: 34315433Free PMC Article
EAU guidelines on primary urethral carcinoma.
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Cryotherapy for localised prostate cancer.
Shelley M, Wilt TJ, Coles B, Mason MD
Cochrane Database Syst Rev 2007 Jul 18;(3):CD005010. doi: 10.1002/14651858.CD005010.pub2. PMID: 17636783
VI--choosing the right reconstruction for your female patients.
Stenzl A, Strasser H, Hobisch A, Bartsch G
Semin Urol Oncol 2001 Feb;19(1):9-17. PMID: 11246739

Recent systematic reviews

Skene's Gland Malignancy: A Case Report and Systematic Review.
Slopnick EA, Bagby C, Mahran A, Nagel C, Garcia J, El-Nashar S, Hijaz AK
Urology 2022 Jul;165:36-43. Epub 2022 Feb 19 doi: 10.1016/j.urology.2022.02.004. PMID: 35192863
Incidence, risk factors and outcomes of urethral recurrence after radical cystectomy for bladder cancer: A systematic review and meta-analysis.
Laukhtina E, Mori K, D Andrea D, Moschini M, Abufaraj M, Soria F, Mari A, Krajewski W, Albisinni S, Teoh JY, Quhal F, Sari Motlagh R, Mostafaei H, Katayama S, Grossmann NС, Rajwa P, Enikeev D, Zimmermann K, Fajkovic H, Glybochko P, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)
Urol Oncol 2021 Dec;39(12):806-815. Epub 2021 Jul 13 doi: 10.1016/j.urolonc.2021.06.009. PMID: 34266740
A systematic review and meta-analysis on complications of transanal total mesorectal excision.
An Y, Roodbeen SX, Talboom K, Tanis PJ, Bemelman WA, Hompes R
Colorectal Dis 2021 Oct;23(10):2527-2538. Epub 2021 Jul 11 doi: 10.1111/codi.15792. PMID: 34174138
Ureteral involvement by metastatic malignant disease.
Hu J, Deng J, Guo J, Fu B
Clin Exp Metastasis 2019 Dec;36(6):499-509. Epub 2019 Aug 24 doi: 10.1007/s10585-019-09989-8. PMID: 31446521
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article

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