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Genitourinary System Carcinoma

MedGen UID:
1708680
•Concept ID:
C5236008
•
Neoplastic Process

Definition

A carcinoma arising from the genitourinary system. Representative examples include kidney carcinoma, bladder carcinoma, prostate carcinoma, endometrial carcinoma, cervical carcinoma, and ovarian carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGenitourinary System Carcinoma

Professional guidelines

PubMed

Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article

Diagnosis

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Uncommon and Difficult High-Grade Endometrial Carcinomas.
Mirkovic J
Surg Pathol Clin 2022 Jun;15(2):301-314. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.007. PMID: 35715163
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

Therapy

Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial.
Grivas P, Park SH, Voog E, Caserta C, Gurney H, Bellmunt J, Kalofonos H, Ullén A, Loriot Y, Sridhar SS, Yamamoto Y, Petrylak DP, Sternberg CN, Gupta S, Huang B, Costa N, Laliberte RJ, di Pietro A, Valderrama BP, Powles T
Eur Urol 2023 Jul;84(1):95-108. Epub 2023 Apr 28 doi: 10.1016/j.eururo.2023.03.030. PMID: 37121850
Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Treatment of patients with metastatic urothelial cancer "unfit" for Cisplatin-based chemotherapy.
Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

Prognosis

Avelumab First-Line Maintenance for Advanced Urothelial Carcinoma: Results From the JAVELIN Bladder 100 Trial After ≥2 Years of Follow-Up.
Powles T, Park SH, Caserta C, Valderrama BP, Gurney H, Ullén A, Loriot Y, Sridhar SS, Sternberg CN, Bellmunt J, Aragon-Ching JB, Wang J, Huang B, Laliberte RJ, di Pietro A, Grivas P
J Clin Oncol 2023 Jul 1;41(19):3486-3492. Epub 2023 Apr 18 doi: 10.1200/JCO.22.01792. PMID: 37071838Free PMC Article
Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Practical Molecular Testing in a Clinical Genitourinary Service.
Magers MJ, Cheng L
Arch Pathol Lab Med 2020 Mar;144(3):277-289. Epub 2019 Aug 2 doi: 10.5858/arpa.2019-0134-RA. PMID: 31373513
Propensity Score Analysis of Radical Cystectomy Versus Bladder-Sparing Trimodal Therapy in the Setting of a Multidisciplinary Bladder Cancer Clinic.
Kulkarni GS, Hermanns T, Wei Y, Bhindi B, Satkunasivam R, Athanasopoulos P, Bostrom PJ, Kuk C, Li K, Templeton AJ, Sridhar SS, van der Kwast TH, Chung P, Bristow RG, Milosevic M, Warde P, Fleshner NE, Jewett MAS, Bashir S, Zlotta AR
J Clin Oncol 2017 Jul 10;35(20):2299-2305. Epub 2017 Apr 14 doi: 10.1200/JCO.2016.69.2327. PMID: 28410011
Management of Renal Masses and Localized Renal Cancer: Systematic Review and Meta-Analysis.
Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R, Iyoha E, Bass EB, Allaf ME
J Urol 2016 Oct;196(4):989-99. Epub 2016 May 6 doi: 10.1016/j.juro.2016.04.081. PMID: 27157369Free PMC Article

Clinical prediction guides

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.
Feng H, Deng Z, Huang Y, Liu Z, Ruan Y, Wang T, Liu J
Front Immunol 2023;14:1219209. Epub 2023 Aug 17 doi: 10.3389/fimmu.2023.1219209. PMID: 37662947Free PMC Article
T1 bladder carcinoma with variant histology: pathological features and clinical significance.
Lopez-Beltran A, Blanca A, Cimadamore A, Montironi R, Luque RJ, Volavšek M, Cheng L
Virchows Arch 2022 May;480(5):989-998. Epub 2022 Feb 4 doi: 10.1007/s00428-021-03264-6. PMID: 35122124Free PMC Article
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Carcinomas and sarcomas of Bartholin gland. A report of nine cases and review of the literature.
Kozakiewicz B, Dmoch-Gajzlerska E, Roszkowska-Purska K
Eur J Gynaecol Oncol 2014;35(3):243-9. PMID: 24984535
Collecting duct carcinoma versus renal medullary carcinoma: an appeal for nosologic and biological clarity.
Amin MB, Smith SC, Agaimy A, Argani P, Compérat EM, Delahunt B, Epstein JI, Eble JN, Grignon DJ, Hartmann A, Hes O, Hirsch MS, Jimenez RE, Kunju LP, Martignoni G, McKenney JK, Moch H, Montironi R, Paner GP, Rao P, Srigley JR, Tickoo SK, Reuter VE
Am J Surg Pathol 2014 Jul;38(7):871-4. doi: 10.1097/PAS.0000000000000222. PMID: 24805860

Recent systematic reviews

Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Management of Renal Masses and Localized Renal Cancer: Systematic Review and Meta-Analysis.
Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R, Iyoha E, Bass EB, Allaf ME
J Urol 2016 Oct;196(4):989-99. Epub 2016 May 6 doi: 10.1016/j.juro.2016.04.081. PMID: 27157369Free PMC Article
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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