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Recurrent Dedifferentiated Liposarcoma

MedGen UID:
1662508
•Concept ID:
C4725858
•
Neoplastic Process

Definition

The reemergence of dedifferentiated liposarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Dedifferentiated Liposarcoma

Professional guidelines

PubMed

Surgical Management of Retroperitoneal Sarcoma.
Dominguez DA, Sampath S, Agulnik M, Liang Y, Nguyen B, Trisal V, Melstrom LG, Lewis AG, Paz IB, Roberts RF, Tseng WW
Curr Oncol 2023 Apr 29;30(5):4618-4631. doi: 10.3390/curroncol30050349. PMID: 37232807Free PMC Article
Myxoid Liposarcomas: Systemic Treatment Options.
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model.
Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM
Biomed Pharmacother 2019 Sep;117:109093. Epub 2019 Jun 11 doi: 10.1016/j.biopha.2019.109093. PMID: 31200257
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL
BMC Cancer 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0. PMID: 30249211Free PMC Article

Diagnosis

Recurrent dedifferentiated liposarcoma of the spermatic cord simulating malignant fibrous histiocytoma: an immunohistochemical and ultrastructural study.
Chan YF, Yuen MY, Ma LT, Li MK
Pathology 1987 Jan;19(1):99-102. doi: 10.3109/00313028709065147. PMID: 3035471

Therapy

The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model.
Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM
Biomed Pharmacother 2019 Sep;117:109093. Epub 2019 Jun 11 doi: 10.1016/j.biopha.2019.109093. PMID: 31200257
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL
BMC Cancer 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0. PMID: 30249211Free PMC Article

Prognosis

Recurrent Dedifferentiated Liposarcoma Arising from the Small Bowel Mesentery: A Case Report.
Panagiotopoulos N, Kyriakides C, Weerakkody RA, Ahma R, Buchanan G, Lowdell C, Jiao LR
J Gastrointest Cancer 2012 Sep;43 Suppl 1:S175-7. doi: 10.1007/s12029-011-9357-y. PMID: 22207349
Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura.
Coulibaly B, Bouvier C, Payan MJ, Thomas P
Interact Cardiovasc Thorac Surg 2009 Oct;9(4):741-2. Epub 2009 Jul 9 doi: 10.1510/icvts.2009.209494. PMID: 19589790

Supplemental Content

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