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FNCLCC Sarcoma Grade 3

MedGen UID:
235578
•Concept ID:
C1335915
•
Neoplastic Process
Synonyms: Sarcoma Differentiation Score 3; Sarcoma FNCLCC Grade 3

Definition

A sarcoma with a total score of 6 or higher according to the FNCLCC guidelines. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFNCLCC Sarcoma Grade 3

Professional guidelines

PubMed

Soft Tissue Sarcomas of the Head and Neck Region with Skull Base/Intracranial Invasion: Review of Surgical Outcomes and Multimodal Treatment Strategies: A Retrospective Case Series.
Habib A, Edem I, Bell D, Su SY, Hanna EY, Kupferman ME, DeMonte F, Raza SM
Curr Oncol 2022 Sep 14;29(9):6540-6550. doi: 10.3390/curroncol29090514. PMID: 36135083Free PMC Article
Safety and efficacy of intensity-modulated radiotherapy in the management of spermatic cord sarcoma.
Cerda T, Martin É, Truc G, Créhange G, Maingon P
Cancer Radiother 2017 Feb;21(1):16-20. Epub 2016 Dec 29 doi: 10.1016/j.canrad.2016.07.102. PMID: 28041814
Prognostic factors of primary resected retroperitoneal soft tissue sarcoma: Analysis from a single asian tertiary center and external validation of gronchi's nomogram.
Chou YS, Liu CY, Chang YH, King KL, Chen PC, Pan CC, Shen SH, Liu YM, Lin AT, Chen KK, Shyr YM, Lee RC, Chao TC, Yang MH, Chan CH, You JY, Yen CC
J Surg Oncol 2016 Mar;113(4):355-60. Epub 2016 Jan 8 doi: 10.1002/jso.24155. PMID: 26749009

Recent clinical studies

Etiology

Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs.
Morabito S, Specchi S, Di Donato P, Pollard D, Dennis R, De Risio L, Bacon NJ, Potamopoulou M, Rupp S, Corlazzoli D, Ribeiro J, Cozzi F, Jurina K, Cappello R, Mercuriali E, Beckmann K, Flegel T, Menchetti M, König F, Matiasek K, Rosati M
J Vet Intern Med 2023 Nov-Dec;37(6):2278-2290. Epub 2023 Sep 19 doi: 10.1111/jvim.16839. PMID: 37726924Free PMC Article
Macrophage numbers in the marginal area of sarcomas predict clinical prognosis.
Umakoshi M, Nakamura A, Tsuchie H, Li Z, Kudo-Asabe Y, Miyabe K, Ito Y, Yoshida M, Nagasawa H, Okada K, Nanjo H, Maeda D, Miyakoshi N, Tanaka M, Goto A
Sci Rep 2023 Jan 23;13(1):1290. doi: 10.1038/s41598-023-28024-1. PMID: 36690825Free PMC Article
Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy.
Sedaghat S, Salehi Ravesh M, Sedaghat M, Both M, Jansen O
Radiol Oncol 2021 Jan 29;55(2):158-163. doi: 10.2478/raon-2021-0007. PMID: 33600679Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Hyperthermia in soft tissue sarcoma.
Lindner LH, Issels RD
Curr Treat Options Oncol 2011 Mar;12(1):12-20. doi: 10.1007/s11864-011-0144-6. PMID: 21360087

Diagnosis

Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs.
Morabito S, Specchi S, Di Donato P, Pollard D, Dennis R, De Risio L, Bacon NJ, Potamopoulou M, Rupp S, Corlazzoli D, Ribeiro J, Cozzi F, Jurina K, Cappello R, Mercuriali E, Beckmann K, Flegel T, Menchetti M, König F, Matiasek K, Rosati M
J Vet Intern Med 2023 Nov-Dec;37(6):2278-2290. Epub 2023 Sep 19 doi: 10.1111/jvim.16839. PMID: 37726924Free PMC Article
Role of the Immunohistochemical ZEB1 Expression in Uterine Mesenchymal Neoplasms.
Çelik M, Çelik ZE
Int J Surg Pathol 2022 Aug;30(5):520-527. Epub 2022 Jan 7 doi: 10.1177/10668969211070180. PMID: 34994578
Giant leiomyosarcoma of the transverse colon.
Nguyen C, Athigaman M, Qureshi A
BMJ Case Rep 2021 Dec 2;14(12) doi: 10.1136/bcr-2021-246646. PMID: 34857593Free PMC Article
Ki-67 immunoexpression and radiological assessment of necrosis improves accuracy of conventional and modified core biopsy systems in predicting the final grade assigned to adult-soft tissue sarcomas. An international collaborative study.
Machado I, Cruz J, Righi A, Gambarotti M, Ferrari C, Ruengwanichayakun P, Giner F, Rausell N, Lavernia J, Sugita S, Najera L, Suarez L, Sanjuan X, García JAN, García Del Muro FJ, Gómez-Mateo MC, Valladares MM, Ramos-Oliver I, Romagosa C, Parafioriti A, Elisabetta A, di Bernardo A, Navarro S, Hasegawa T, Arana E, Llombart-Bosch A
Pathol Res Pract 2021 Sep;225:153562. Epub 2021 Jul 22 doi: 10.1016/j.prp.2021.153562. PMID: 34329836
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article

Therapy

Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients.
Zhuang A, Yue X, Tong H, Zhang Y, He F, Lu W
Front Endocrinol (Lausanne) 2023;14:1160817. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1160817. PMID: 37534215Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors.
Nishida Y, Urakawa H, Nakayama R, Kobayashi E, Ozaki T, Ae K, Matsumoto Y, Tsuchiya H, Goto T, Hiraga H, Naka N, Takahashi S, Ando Y, Ando M, Kuwatsuka Y, Hamada S, Ueda T, Kawai A
Int J Cancer 2021 Jan 1;148(1):140-149. Epub 2020 Aug 3 doi: 10.1002/ijc.33201. PMID: 32638374
Adjuvant chemotherapy and postoperative radiotherapy in high-risk soft tissue sarcoma patients defined by biological risk factors-A Scandinavian Sarcoma Group study (SSG XX).
Sundby Hall K, Bruland ØS, Bjerkehagen B, Zaikova O, Engellau J, Hagberg O, Hansson L, Hagberg H, Ahlström M, Knobel H, Papworth K, Zemmler M, Goplen D, Bauer HCF, Eriksson M
Eur J Cancer 2018 Aug;99:78-85. Epub 2018 Jun 19 doi: 10.1016/j.ejca.2018.05.011. PMID: 29929092
Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005).
Brennan B, Zanetti I, Orbach D, Gallego S, Francotte N, Van Noesel M, Kelsey A, Casanova M, De Salvo GL, Bisogno G, Ferrari A
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26942. PMID: 29286582

Prognosis

Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs.
Morabito S, Specchi S, Di Donato P, Pollard D, Dennis R, De Risio L, Bacon NJ, Potamopoulou M, Rupp S, Corlazzoli D, Ribeiro J, Cozzi F, Jurina K, Cappello R, Mercuriali E, Beckmann K, Flegel T, Menchetti M, König F, Matiasek K, Rosati M
J Vet Intern Med 2023 Nov-Dec;37(6):2278-2290. Epub 2023 Sep 19 doi: 10.1111/jvim.16839. PMID: 37726924Free PMC Article
Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy.
Sedaghat S, Salehi Ravesh M, Sedaghat M, Both M, Jansen O
Radiol Oncol 2021 Jan 29;55(2):158-163. doi: 10.2478/raon-2021-0007. PMID: 33600679Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Surgical margins do not affect prognosis in high grade myxofibrosarcoma.
Sambri A, Bianchi G, Righi A, Ferrari C, Donati D
Eur J Surg Oncol 2016 Jul;42(7):1042-8. Epub 2016 May 27 doi: 10.1016/j.ejso.2016.05.015. PMID: 27260849
Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database.
Italiano A, Delva F, Mathoulin-Pelissier S, Le Cesne A, Bonvalot S, Terrier P, Trassard M, Michels JJ, Blay JY, Coindre JM, Bui B
Ann Oncol 2010 Dec;21(12):2436-2441. Epub 2010 May 3 doi: 10.1093/annonc/mdq238. PMID: 20439343

Clinical prediction guides

Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs.
Morabito S, Specchi S, Di Donato P, Pollard D, Dennis R, De Risio L, Bacon NJ, Potamopoulou M, Rupp S, Corlazzoli D, Ribeiro J, Cozzi F, Jurina K, Cappello R, Mercuriali E, Beckmann K, Flegel T, Menchetti M, König F, Matiasek K, Rosati M
J Vet Intern Med 2023 Nov-Dec;37(6):2278-2290. Epub 2023 Sep 19 doi: 10.1111/jvim.16839. PMID: 37726924Free PMC Article
Role of the Immunohistochemical ZEB1 Expression in Uterine Mesenchymal Neoplasms.
Çelik M, Çelik ZE
Int J Surg Pathol 2022 Aug;30(5):520-527. Epub 2022 Jan 7 doi: 10.1177/10668969211070180. PMID: 34994578
Configuration of soft-tissue sarcoma on MRI correlates with grade of malignancy.
Sedaghat S, Salehi Ravesh M, Sedaghat M, Both M, Jansen O
Radiol Oncol 2021 Jan 29;55(2):158-163. doi: 10.2478/raon-2021-0007. PMID: 33600679Free PMC Article
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on (18)F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma.
Li CP, Liu DN, Zhou NN, Tian XY, Wang Z, Liu BN, Hao CY
Contrast Media Mol Imaging 2021;2021:7191363. Epub 2021 Jan 6 doi: 10.1155/2021/7191363. PMID: 33505228Free PMC Article
Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database.
Italiano A, Delva F, Mathoulin-Pelissier S, Le Cesne A, Bonvalot S, Terrier P, Trassard M, Michels JJ, Blay JY, Coindre JM, Bui B
Ann Oncol 2010 Dec;21(12):2436-2441. Epub 2010 May 3 doi: 10.1093/annonc/mdq238. PMID: 20439343

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