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Anal Intraepithelial Neoplasia 2

MedGen UID:
1678069
•Concept ID:
C4764341
•
Neoplastic Process
Synonym: Anal Squamous Intraepithelial Neoplasia 2

Definition

Anal canal or perianal skin intraepithelial neoplasia with moderate dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Intraepithelial Neoplasia 2

Professional guidelines

PubMed

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Incidence and mortality from cervical cancer and other malignancies after treatment of cervical intraepithelial neoplasia: a systematic review and meta-analysis of the literature.
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
Anal squamous intraepithelial lesions: an update and proposed management algorithm.
Chittleborough T, Tapper R, Eglinton T, Frizelle F
Tech Coloproctol 2020 Feb;24(2):95-103. Epub 2019 Dec 13 doi: 10.1007/s10151-019-02133-4. PMID: 31834554

Recent clinical studies

Etiology

The correlation Between anal pap cytology and histologic outcomes in HIV-Positive males.
McCutcheon T, Hawkins AT, Ford MM, Hopkins MB, Geiger T, Muldoon RL
Am J Surg 2022 Apr;223(4):759-763. Epub 2021 Jul 8 doi: 10.1016/j.amjsurg.2021.06.020. PMID: 34266659
Anal and Cervical High-Risk Human Papillomavirus Genotyping in Women With and Without Genital Neoplasia.
Bregar AJ, Cronin B, Luis C, DiSilvestro P, Schechter S, Pisharodi L, Raker C, Clark M, Robison K
J Low Genit Tract Dis 2018 Apr;22(2):115-119. doi: 10.1097/LGT.0000000000000368. PMID: 29481422
Anal Cytology and Human Papillomavirus Genotyping in Women With a History of Lower Genital Tract Neoplasia Compared With Low-Risk Women.
Robison K, Cronin B, Bregar A, Luis C, DiSilvestro P, Schechter S, Pisharodi L, Raker C, Clark M
Obstet Gynecol 2015 Dec;126(6):1294-1300. doi: 10.1097/AOG.0000000000001135. PMID: 26551180Free PMC Article
Prospective Single-Center Observational Study of Routine Histopathologic Evaluation of Macroscopically Normal Hemorrhoidectomy and Fissurectomy Specimens in Search of Anal Intraepithelial Neoplasia.
Bauer P, Fléjou JF, Etienney I; Proctological Prospective Diaconesses Group
Dis Colon Rectum 2015 Jul;58(7):692-7. doi: 10.1097/DCR.0000000000000387. PMID: 26200684
Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review.
Stier EA, Sebring MC, Mendez AE, Ba FS, Trimble DD, Chiao EY
Am J Obstet Gynecol 2015 Sep;213(3):278-309. Epub 2015 Mar 19 doi: 10.1016/j.ajog.2015.03.034. PMID: 25797230Free PMC Article

Diagnosis

The correlation Between anal pap cytology and histologic outcomes in HIV-Positive males.
McCutcheon T, Hawkins AT, Ford MM, Hopkins MB, Geiger T, Muldoon RL
Am J Surg 2022 Apr;223(4):759-763. Epub 2021 Jul 8 doi: 10.1016/j.amjsurg.2021.06.020. PMID: 34266659
Classifying Anal Intraepithelial Neoplasia 2 Based on LAST Recommendations.
Liu Y, McCluggage WG, Darragh TM, Zheng W, Roberts JM, Park KJ, Hui P, Blakely M, Sigel K, Gaisa MM
Am J Clin Pathol 2021 May 18;155(6):845-852. doi: 10.1093/ajcp/aqaa188. PMID: 33210115Free PMC Article
Anal Cytology and Human Papillomavirus Genotyping in Women With a History of Lower Genital Tract Neoplasia Compared With Low-Risk Women.
Robison K, Cronin B, Bregar A, Luis C, DiSilvestro P, Schechter S, Pisharodi L, Raker C, Clark M
Obstet Gynecol 2015 Dec;126(6):1294-1300. doi: 10.1097/AOG.0000000000001135. PMID: 26551180Free PMC Article
Prospective Single-Center Observational Study of Routine Histopathologic Evaluation of Macroscopically Normal Hemorrhoidectomy and Fissurectomy Specimens in Search of Anal Intraepithelial Neoplasia.
Bauer P, Fléjou JF, Etienney I; Proctological Prospective Diaconesses Group
Dis Colon Rectum 2015 Jul;58(7):692-7. doi: 10.1097/DCR.0000000000000387. PMID: 26200684
Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.
Sendagorta E, Herranz P, Guadalajara H, Bernardino JI, Viguer JM, Beato MJ, García-Olmo D, Peña JM
Dis Colon Rectum 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095. PMID: 24608304

Prognosis

Condyloma acuminatum of the anal canal, treated with endoscopic submucosal dissection.
Sasaki A, Nakajima T, Egashira H, Takeda K, Tokoro S, Ichita C, Masuda S, Uojima H, Koizumi K, Kinbara T, Sakamoto T, Saito Y, Kako M
World J Gastroenterol 2016 Feb 28;22(8):2636-41. doi: 10.3748/wjg.v22.i8.2636. PMID: 26937152Free PMC Article
Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review.
Stier EA, Sebring MC, Mendez AE, Ba FS, Trimble DD, Chiao EY
Am J Obstet Gynecol 2015 Sep;213(3):278-309. Epub 2015 Mar 19 doi: 10.1016/j.ajog.2015.03.034. PMID: 25797230Free PMC Article
Performance of anal cytology in a clinical setting when measured against histology and high-resolution anoscopy findings.
Nathan M, Singh N, Garrett N, Hickey N, Prevost T, Sheaff M
AIDS 2010 Jan 28;24(3):373-9. doi: 10.1097/QAD.0b013e328333ab8e. PMID: 20057313

Clinical prediction guides

Condyloma acuminatum of the anal canal, treated with endoscopic submucosal dissection.
Sasaki A, Nakajima T, Egashira H, Takeda K, Tokoro S, Ichita C, Masuda S, Uojima H, Koizumi K, Kinbara T, Sakamoto T, Saito Y, Kako M
World J Gastroenterol 2016 Feb 28;22(8):2636-41. doi: 10.3748/wjg.v22.i8.2636. PMID: 26937152Free PMC Article
Prospective Single-Center Observational Study of Routine Histopathologic Evaluation of Macroscopically Normal Hemorrhoidectomy and Fissurectomy Specimens in Search of Anal Intraepithelial Neoplasia.
Bauer P, Fléjou JF, Etienney I; Proctological Prospective Diaconesses Group
Dis Colon Rectum 2015 Jul;58(7):692-7. doi: 10.1097/DCR.0000000000000387. PMID: 26200684
Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.
Sendagorta E, Herranz P, Guadalajara H, Bernardino JI, Viguer JM, Beato MJ, García-Olmo D, Peña JM
Dis Colon Rectum 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095. PMID: 24608304
The psychological impact of being screened for anal cancer in HIV-infected men who have sex with men.
Tinmouth J, Raboud J, Ali M, Malloch L, Su D, Sano M, Lytwyn A, Rourke SB, Rabeneck L, Salit I
Dis Colon Rectum 2011 Mar;54(3):352-9. doi: 10.1007/DCR.0b013e31820349c1. PMID: 21304309
Performance of anal cytology in a clinical setting when measured against histology and high-resolution anoscopy findings.
Nathan M, Singh N, Garrett N, Hickey N, Prevost T, Sheaff M
AIDS 2010 Jan 28;24(3):373-9. doi: 10.1097/QAD.0b013e328333ab8e. PMID: 20057313

Recent systematic reviews

Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review.
Stier EA, Sebring MC, Mendez AE, Ba FS, Trimble DD, Chiao EY
Am J Obstet Gynecol 2015 Sep;213(3):278-309. Epub 2015 Mar 19 doi: 10.1016/j.ajog.2015.03.034. PMID: 25797230Free PMC Article

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