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High Grade Intraepithelial Neoplasia

MedGen UID:
234349
•Concept ID:
C1334015
•
Neoplastic Process

Definition

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as grade II (moderate dysplasia) or grade III (severe dysplasia). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Intraepithelial Neoplasia

Professional guidelines

PubMed

Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
The current recommendation for the management of isolated high-grade prostatic intraepithelial neoplasia.
Morote J, Schwartzmann I, Celma A, Roche S, de Torres IM, Mast R, Semidey ME, Regis L, Santamaria A, Planas J, Trilla E
BJU Int 2022 May;129(5):627-633. Epub 2021 Aug 25 doi: 10.1111/bju.15568. PMID: 34375498
Endoscopic treatment of high-grade intraepithelial neoplasia and early cancer in Barrett oesophagus.
Bergman JJ
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):889-907. doi: 10.1016/j.bpg.2005.03.002. PMID: 16338648

Recent clinical studies

Etiology

Characteristics of multiple early gastric cancer and gastric high-grade intraepithelial neoplasia.
Chen Y, He L, Zheng X
Medicine (Baltimore) 2023 Dec 8;102(49):e36439. doi: 10.1097/MD.0000000000036439. PMID: 38065868Free PMC Article
Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Radiofrequency ablation for Barrett's esophagus-related neoplasia.
Krajciova J, Vackova Z, Spicak J, Martinek J
Minerva Chir 2018 Aug;73(4):366-377. Epub 2018 May 25 doi: 10.23736/S0026-4733.18.07783-0. PMID: 29806757

Diagnosis

Characteristics of multiple early gastric cancer and gastric high-grade intraepithelial neoplasia.
Chen Y, He L, Zheng X
Medicine (Baltimore) 2023 Dec 8;102(49):e36439. doi: 10.1097/MD.0000000000036439. PMID: 38065868Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.
Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
Endoscopic and Histopathology Characteristics in Patients with Esophageal High-Grade Intraepithelial Neoplasia.
Sang HM, Cao JL, Soyfoo MD, Zhang WM, Jiang JX, Xu SF
Dig Surg 2019;36(5):384-393. Epub 2018 Jun 26 doi: 10.1159/000490112. PMID: 29945127

Therapy

Histopathological Characteristics and Therapeutic Outcomes of Endoscopic Submucosal Dissection for Gastric High-Grade Intraepithelial Neoplasia.
Zhang HH, Soyfoo MD, Cao JL, Sang HM, Xu SF, Jiang JX
J Laparoendosc Adv Surg Tech A 2022 Apr;32(4):413-421. Epub 2021 Dec 28 doi: 10.1089/lap.2020.0035. PMID: 34962142
Clinical relevance and implications of HPV-induced neoplasia in different anatomical locations.
Prigge ES, von Knebel Doeberitz M, Reuschenbach M
Mutat Res Rev Mutat Res 2017 Apr-Jun;772:51-66. Epub 2016 Jun 22 doi: 10.1016/j.mrrev.2016.06.005. PMID: 28528690
Systematic review and meta-analysis of endoscopic ablative treatment of Barrett's esophagus.
De Souza TF, Artifon EL, Mestieri LH, Reimão SM, Aires FT, Bernardo WM, Otoch JP, De Moura EG
Rev Gastroenterol Peru 2014 Jul;34(3):217-24. PMID: 25293990
Endoscopic treatment of high-grade intraepithelial neoplasia and early cancer in Barrett oesophagus.
Bergman JJ
Best Pract Res Clin Gastroenterol 2005 Dec;19(6):889-907. doi: 10.1016/j.bpg.2005.03.002. PMID: 16338648
Curative treatment for high-grade intraepithelial neoplasia in Barrett's esophagus.
Behrens A, May A, Gossner L, Günter E, Pech O, Vieth M, Stolte M, Seitz G, Ell C
Endoscopy 2005 Oct;37(10):999-1005. doi: 10.1055/s-2005-870352. PMID: 16189774

Prognosis

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
The current recommendation for the management of isolated high-grade prostatic intraepithelial neoplasia.
Morote J, Schwartzmann I, Celma A, Roche S, de Torres IM, Mast R, Semidey ME, Regis L, Santamaria A, Planas J, Trilla E
BJU Int 2022 May;129(5):627-633. Epub 2021 Aug 25 doi: 10.1111/bju.15568. PMID: 34375498
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
High-grade anal intraepithelial neoplasia: Progression to invasive cancer is not a certainty.
Gautier M, Brochard C, Lion A, Henno S, Mallet AL, Bodere A, Bouguen G, Lièvre A, Siproudhis L
Dig Liver Dis 2016 Jul;48(7):806-11. Epub 2016 Mar 28 doi: 10.1016/j.dld.2016.03.011. PMID: 27103359

Clinical prediction guides

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer.
Liu X, Zhao S, Wang K, Zhou L, Jiang M, Gao Y, Yang R, Yan S, Zhang W, Lu B, Liu F, Zhao R, Liu W, Zhang Z, Liu K, Li X, Dong Z
Nat Commun 2023 Aug 8;14(1):4779. doi: 10.1038/s41467-023-40343-5. PMID: 37553345Free PMC Article
Machine learning-based automated sponge cytology for screening of oesophageal squamous cell carcinoma and adenocarcinoma of the oesophagogastric junction: a nationwide, multicohort, prospective study.
Gao Y, Xin L, Lin H, Yao B, Zhang T, Zhou AJ, Huang S, Wang JH, Feng YD, Yao SH, Guo Y, Dang T, Meng XM, Yang ZZ, Jia WQ, Pang HF, Tian XJ, Deng B, Wang JP, Fan WC, Wang J, Shi LH, Yang GY, Sun C, Wang W, Zang JC, Li SY, Shi RH, Li ZS, Wang LW
Lancet Gastroenterol Hepatol 2023 May;8(5):432-445. Epub 2023 Mar 14 doi: 10.1016/S2468-1253(23)00004-3. PMID: 36931287
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer.
Huang S, Guo Y, Li ZW, Shui G, Tian H, Li BW, Kadeerhan G, Li ZX, Li X, Zhang Y, Zhou T, You WC, Pan KF, Li WQ
JAMA Netw Open 2021 Jun 1;4(6):e2114186. doi: 10.1001/jamanetworkopen.2021.14186. PMID: 34156450Free PMC Article
High-grade anal intraepithelial neoplasia: Progression to invasive cancer is not a certainty.
Gautier M, Brochard C, Lion A, Henno S, Mallet AL, Bodere A, Bouguen G, Lièvre A, Siproudhis L
Dig Liver Dis 2016 Jul;48(7):806-11. Epub 2016 Mar 28 doi: 10.1016/j.dld.2016.03.011. PMID: 27103359
Endoscopic therapy of Barrett's esophagus.
Pech O, Ell C
Curr Opin Gastroenterol 2009 Sep;25(5):405-11. doi: 10.1097/MOG.0b013e32832d9b71. PMID: 19474724

Recent systematic reviews

The Application of Core Needle Biopsy Through the Trocar Hole in the Surgical Operation of Endoscopically Unresectable Giant Colon Polyps: A Systematic Review Study.
Kang CB, Li XB, Hou S, Zhang J, Chi XQ, Shan HF, Zhang QJ, Liu TJ
Adv Ther 2021 May;38(5):2662-2672. Epub 2021 Apr 17 doi: 10.1007/s12325-021-01635-8. PMID: 33864202
The risk factors for delayed bleeding after endoscopic resection of colorectal tumors: a meta-analysis.
Xu Y, Zhong S, Liang W, Lin XL
Expert Rev Gastroenterol Hepatol 2020 Nov;14(11):1083-1092. Epub 2020 Aug 12 doi: 10.1080/17474124.2020.1801416. PMID: 32721191
High-risk HPV testing in the management of atypical glandular cells: A systematic review and meta-analysis.
Verdoodt F, Jiang X, Williams M, Schnatz PF, Arbyn M
Int J Cancer 2016 Jan 15;138(2):303-10. Epub 2015 Feb 5 doi: 10.1002/ijc.29424. PMID: 25583258
Systematic review and meta-analysis of endoscopic ablative treatment of Barrett's esophagus.
De Souza TF, Artifon EL, Mestieri LH, Reimão SM, Aires FT, Bernardo WM, Otoch JP, De Moura EG
Rev Gastroenterol Peru 2014 Jul;34(3):217-24. PMID: 25293990

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