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Metastatic Bladder Plasmacytoid Urothelial Carcinoma

MedGen UID:
1682285
•Concept ID:
C4763829
•
Neoplastic Process
Synonyms: Metastatic Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant; Metastatic Invasive Bladder Urothelial Carcinoma, Plasmacytoid Variant; Metastatic Plasmacytoid Urothelial Carcinoma of the Bladder

Definition

Bladder plasmacytoid urothelial carcinoma that has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bladder Plasmacytoid Urothelial Carcinoma

Recent clinical studies

Etiology

Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Urothelial Carcinoma In Situ of the Bladder With Glandular Differentiation: Report of 92 Cases.
Yang Z, Epstein JI
Am J Surg Pathol 2018 Jul;42(7):971-976. doi: 10.1097/PAS.0000000000001073. PMID: 29683821
Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report.
Jibril A, Stevens AC
Am J Case Rep 2018 Feb 13;19:158-162. doi: 10.12659/ajcr.906679. PMID: 29434183Free PMC Article
Plasmacytoid urothelial carcinoma, a chemosensitive cancer with poor prognosis, and peritoneal carcinomatosis.
Dayyani F, Czerniak BA, Sircar K, Munsell MF, Millikan RE, Dinney CP, Siefker-Radtke AO
J Urol 2013 May;189(5):1656-61. Epub 2012 Nov 15 doi: 10.1016/j.juro.2012.11.084. PMID: 23159581Free PMC Article
Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread.
Ricardo-Gonzalez RR, Nguyen M, Gokden N, Sangoi AR, Presti JC Jr, McKenney JK
J Urol 2012 Mar;187(3):852-5. Epub 2012 Jan 15 doi: 10.1016/j.juro.2011.10.145. PMID: 22245324

Diagnosis

Metastatic Plasmacytoid Bladder Cancer Harboring a CDH-1 Mutation and Producing High Levels of CA 19-9. A Case Report and Literature Review.
Telfah M, Parikh RA, Zhang D, Kasi A
Am J Case Rep 2020 Jul 9;21:e923130. doi: 10.12659/AJCR.923130. PMID: 32644978Free PMC Article
Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report.
Jibril A, Stevens AC
Am J Case Rep 2018 Feb 13;19:158-162. doi: 10.12659/ajcr.906679. PMID: 29434183Free PMC Article
Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder.
Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI
Am J Surg Pathol 2017 Nov;41(11):1570-1575. doi: 10.1097/PAS.0000000000000922. PMID: 28786878
Metastatic plasmacytoid urothelial carcinoma: a case report and review of the literature.
Olsen DL, Anderson SR
Acta Cytol 2014;58(1):108-12. Epub 2013 Dec 10 doi: 10.1159/000356420. PMID: 24334972
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589

Therapy

Metastatic Bladder Cancer Expression and Subcellular Localization of Nectin-4 and Trop-2 in Variant Histology: A Rapid Autopsy Study.
Ghali F, Vakar-Lopez F, Roudier MP, Garcia J, Arora S, Cheng HH, Schweizer MT, Haffner MC, Lee JK, Yu EY, Grivas P, Montgomery B, Hsieh AC, Wright JL, Lam HM
Clin Genitourin Cancer 2023 Dec;21(6):669-678. Epub 2023 May 25 doi: 10.1016/j.clgc.2023.05.014. PMID: 37344281Free PMC Article
Metastatic Plasmacytoid Bladder Cancer Harboring a CDH-1 Mutation and Producing High Levels of CA 19-9. A Case Report and Literature Review.
Telfah M, Parikh RA, Zhang D, Kasi A
Am J Case Rep 2020 Jul 9;21:e923130. doi: 10.12659/AJCR.923130. PMID: 32644978Free PMC Article
Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability.
Yang Y, Jain RK, Glenn ST, Xu B, Singh PK, Wei L, Hu Q, Long M, Hutson N, Wang J, Battaglia S, George S
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2019-000128. PMID: 32221012Free PMC Article
First-line pembrolizumab therapy in a cisplatin-ineligible patient with plasmacytoid urothelial carcinoma: A case report.
Hunter L, Moser J, Sturge C, Barraza G, Colonna S
J Oncol Pharm Pract 2020 Jan;26(1):216-219. Epub 2019 Mar 4 doi: 10.1177/1078155219835006. PMID: 30832555
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522

Prognosis

Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report.
Jibril A, Stevens AC
Am J Case Rep 2018 Feb 13;19:158-162. doi: 10.12659/ajcr.906679. PMID: 29434183Free PMC Article
Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder.
Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI
Am J Surg Pathol 2017 Nov;41(11):1570-1575. doi: 10.1097/PAS.0000000000000922. PMID: 28786878
Metastatic plasmacytoid urothelial carcinoma: a case report and review of the literature.
Olsen DL, Anderson SR
Acta Cytol 2014;58(1):108-12. Epub 2013 Dec 10 doi: 10.1159/000356420. PMID: 24334972
Plasmacytoid urothelial carcinoma, a chemosensitive cancer with poor prognosis, and peritoneal carcinomatosis.
Dayyani F, Czerniak BA, Sircar K, Munsell MF, Millikan RE, Dinney CP, Siefker-Radtke AO
J Urol 2013 May;189(5):1656-61. Epub 2012 Nov 15 doi: 10.1016/j.juro.2012.11.084. PMID: 23159581Free PMC Article
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589

Clinical prediction guides

Complete response to anti-PD-L1 antibody in a metastatic bladder cancer associated with novel MSH4 mutation and microsatellite instability.
Yang Y, Jain RK, Glenn ST, Xu B, Singh PK, Wei L, Hu Q, Long M, Hutson N, Wang J, Battaglia S, George S
J Immunother Cancer 2020 Mar;8(1) doi: 10.1136/jitc-2019-000128. PMID: 32221012Free PMC Article
What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Immunohistochemical Differentiation of Plasmacytoid Urothelial Carcinoma From Secondary Carcinoma Involvement of the Bladder.
Borhan WM, Cimino-Mathews AM, Montgomery EA, Epstein JI
Am J Surg Pathol 2017 Nov;41(11):1570-1575. doi: 10.1097/PAS.0000000000000922. PMID: 28786878
Clinical significance of prominent retraction clefts in invasive urothelial carcinoma.
Shah TS, Kaag M, Raman JD, Chan W, Tran T, Kunchala S, Shuman L, DeGraff DJ, Chen G, Warrick JI
Hum Pathol 2017 Mar;61:90-96. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.021. PMID: 27818288

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