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Infundibulo-neurohypophysitis

MedGen UID:
1683829
•Concept ID:
C5190834
•
Disease or Syndrome
Synonyms: Infundibulo neurohypophysitis; infundibulo-neurohypophysitis
SNOMED CT: Infundibulo neurohypophysitis (783158009)
 
Monarch Initiative: MONDO:0016534
Orphanet: ORPHA238305

Definition

A rare acquired pituitary hormone deficiency, a type of primary hypophysitis characterized by an inflammation of the posterior pituitary and the stalk. The major clinical manifestation is diabetes insipidus with polyuria and polydipsia. Less frequent symptoms are headaches, adrenal insufficiency, hyperprolactinemia and hypogonadism. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfundibulo-neurohypophysitis

Recent clinical studies

Etiology

Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.
Patti G, Calandra E, De Bellis A, Gallizia A, Crocco M, Napoli F, Allegri AME, Thiabat HF, Bellastella G, Maiorino MI, Garrè ML, Parodi S, Maghnie M, di Iorgi N
Front Endocrinol (Lausanne) 2020;11:16. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00016. PMID: 32132974Free PMC Article
Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus.
De Bellis A, Colao A, Bizzarro A, Di Salle F, Coronella C, Solimeno S, Vetrano A, Pivonello R, Pisano G, Lombardi G, Bellastella A
J Clin Endocrinol Metab 2002 Aug;87(8):3825-9. doi: 10.1210/jcem.87.8.8757. PMID: 12161517

Diagnosis

Neuroimaging of hypophysitis: etiologies and imaging mimics.
Kurokawa R, Kurokawa M, Baba A, Nakaya M, Kato S, Bapuraj J, Nakata Y, Ota Y, Srinivasan A, Abe O, Moritani T
Jpn J Radiol 2023 Sep;41(9):911-927. Epub 2023 Apr 3 doi: 10.1007/s11604-023-01417-y. PMID: 37010787Free PMC Article
Pituitary Stalk Enlargement in Adults.
Hána V, Salenave S, Chanson P
Neuroendocrinology 2020;110(9-10):809-821. Epub 2020 Feb 20 doi: 10.1159/000506641. PMID: 32074610
Review on Recent Topics in Hypophysitis.
Sugihara H
J Nippon Med Sch 2017;84(5):201-208. doi: 10.1272/jnms.84.201. PMID: 29142180
Lymphocytic infundibulo-neurohypophysitis: a clinical overview.
Johnston PC, Chew LS, Hamrahian AH, Kennedy L
Endocrine 2015 Dec;50(3):531-6. Epub 2015 Jul 29 doi: 10.1007/s12020-015-0707-6. PMID: 26219407
Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant.
Abe T
Brain Tumor Pathol 2008;25(2):59-66. Epub 2008 Nov 6 doi: 10.1007/s10014-008-0234-8. PMID: 18987830

Therapy

Pituitary stalk thickening in patients under 18 years of age - the most common causes and diagnostic procedures.
Moszczyńska E, Baszyńska-Wilk M, Zasada K, Majak D, Szaniawska M, Szalecki M
Pediatr Endocrinol Diabetes Metab 2022;28(3):213-227. doi: 10.5114/pedm.2022.115202. PMID: 35620922Free PMC Article
Anti-pituitary antibodies as a marker of autoimmunity in pituitary glands.
Iwama S, Arima H
Endocr J 2020 Nov 28;67(11):1077-1083. Epub 2020 Oct 14 doi: 10.1507/endocrj.EJ20-0436. PMID: 33055452
Review on Recent Topics in Hypophysitis.
Sugihara H
J Nippon Med Sch 2017;84(5):201-208. doi: 10.1272/jnms.84.201. PMID: 29142180
Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis.
Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, Banno R, Caturegli P, Koike T, Oshida Y, Arima H
Pituitary 2017 Jun;20(3):301-310. doi: 10.1007/s11102-016-0780-8. PMID: 27896569
An elderly patient with transient diabetes insipidus associated with lymphocytic infundibulo-neurohypophysitis.
Takahashi M, Otsuka F, Miyoshi T, Ogura T, Makino H
Endocr J 1999 Oct;46(5):741-6. doi: 10.1507/endocrj.46.741. PMID: 10670763

Prognosis

Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.
Patti G, Calandra E, De Bellis A, Gallizia A, Crocco M, Napoli F, Allegri AME, Thiabat HF, Bellastella G, Maiorino MI, Garrè ML, Parodi S, Maghnie M, di Iorgi N
Front Endocrinol (Lausanne) 2020;11:16. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00016. PMID: 32132974Free PMC Article
Pituitary Stalk Enlargement in Adults.
Hána V, Salenave S, Chanson P
Neuroendocrinology 2020;110(9-10):809-821. Epub 2020 Feb 20 doi: 10.1159/000506641. PMID: 32074610
Review on Recent Topics in Hypophysitis.
Sugihara H
J Nippon Med Sch 2017;84(5):201-208. doi: 10.1272/jnms.84.201. PMID: 29142180
Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features.
Seki T, Yasuda A, Yamaoka T, Imai J, Ito K, Ozawa H, Fukagawa M, Okamatsu C, Nakamura N, Atsumi H, Matsumae M, Takagi A
Tokai J Exp Clin Med 2012 Dec 20;37(4):126-32. PMID: 23238905
Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant.
Abe T
Brain Tumor Pathol 2008;25(2):59-66. Epub 2008 Nov 6 doi: 10.1007/s10014-008-0234-8. PMID: 18987830

Clinical prediction guides

Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.
Patti G, Calandra E, De Bellis A, Gallizia A, Crocco M, Napoli F, Allegri AME, Thiabat HF, Bellastella G, Maiorino MI, Garrè ML, Parodi S, Maghnie M, di Iorgi N
Front Endocrinol (Lausanne) 2020;11:16. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00016. PMID: 32132974Free PMC Article
Usefulness of anti-rabphilin-3A antibodies for diagnosing central diabetes insipidus in the third trimester of pregnancy.
Sakurai K, Yamashita R, Niituma S, Iwama S, Sugimura Y, Arihara Z, Takahashi K
Endocr J 2017 Jun 29;64(6):645-650. Epub 2017 Apr 14 doi: 10.1507/endocrj.EJ17-0028. PMID: 28420857
Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features.
Seki T, Yasuda A, Yamaoka T, Imai J, Ito K, Ozawa H, Fukagawa M, Okamatsu C, Nakamura N, Atsumi H, Matsumae M, Takagi A
Tokai J Exp Clin Med 2012 Dec 20;37(4):126-32. PMID: 23238905
A rare case of central post-gravid diabetes insipidus.
Morrone LF, Saracino A, Ramunni A, Fasianos E, Coratelli P, Passavanti G
Clin Nephrol 2003 Dec;60(6):433-6. doi: 10.5414/cnp60433. PMID: 14690263
Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus.
De Bellis A, Colao A, Bizzarro A, Di Salle F, Coronella C, Solimeno S, Vetrano A, Pivonello R, Pisano G, Lombardi G, Bellastella A
J Clin Endocrinol Metab 2002 Aug;87(8):3825-9. doi: 10.1210/jcem.87.8.8757. PMID: 12161517

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