Increased proportion of CD8-positive, alpha-beta memory T cells

MedGen UID:: 1686644
•Concept ID:: C5139553
•: Finding

HPO:	HP:0410392

Definition

An abnormally elevated proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased proportion of CD8-positive, alpha-beta memory T cells

Abnormal leukocyte count
- Abnormal lymphocyte count
  - Abnormal T cell count
    - Abnormal T cell subset distribution
      - Abnormal proportion of memory T cells
        Abnormal proportion of CD8-positive, alpha-beta memory T cells
        Increased proportion of CD8-positive, alpha-beta memory T cells
        Increased proportion of CD8-positive, alpha-beta TEMRA T cells
        Increased proportion of central memory CD8-positive, alpha-beta T cells
        Increased proportion of effector memory CD8-positive, alpha-beta T cells

Recent clinical studies

Prognosis

Clonal expansion of CD8+ effector T cells in childhood tuberculosis.

Jacobsen M, Detjen AK, Mueller H, Gutschmidt A, Leitner S, Wahn U, Magdorf K, Kaufmann SH
J Immunol 2007 Jul 15;179(2):1331-9. doi: 10.4049/jimmunol.179.2.1331. PMID: 17617626

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Increased proportion of CD8-positive, alpha-beta memory T cells

Definition

Term Hierarchy

Recent clinical studies

Prognosis

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