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Abnormal T cell subset distribution

MedGen UID:: 1371686
•Concept ID:: C4476840
•: Finding

HPO:	HP:0025540

Definition

Any abnormality in the proportion T cells subsets relative to the total number of T cells. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal T cell subset distribution

Abnormal immune system morphology
- Abnormal cellular immune system morphology
  - Abnormal leukocyte morphology
    - Abnormal leukocyte count
      - Abnormal lymphocyte count
        Abnormal T cell count
        Abnormal T cell subset distribution
        Abnormal CD4+CD25+ regulatory T cell proportion
        Decreased proportion of CD4+CD25+ regulatory T cells
        Increased proportion of CD4+CD25+ regulatory T cells
        Abnormal CD4:CD8 ratio
        Decreased CD4:CD8 ratio
        Increased CD4:CD8 ratio
        Abnormal helper T cell proportion
        Decreased helper T cell proportion
        Increased helper T cell proportion
        Abnormal proportion of CD4-positive T cells
        Abnormal proportion of CD4+ effector memory cells
        Abnormal proportion of CD4-positive helper T cells
        Decreased proportion of CD4-positive helper T cells
        Decreased proportion of CD4-positive T cells
        Reduced proportion of CD4+ effector memory T cells
        Increased proportion of CD4-positive T cells
        Elevated proportion of CD4+ effector memory T cells
        Abnormal proportion of CD8-positive T cells
        Decreased proportion of CD8-positive T cells
        Absence of CD8-positive T cells
        Abnormal proportion of double-negative alpha-beta regulatory T cell
        Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells
        Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells
        Abnormal proportion of exhausted T cells
        Increased proportion of exhausted T cells
        Abnormal proportion of gamma-delta T cells
        Decreased proportion of gamma-delta T cells
        Increased proportion of gamma-delta T cells
        Abnormal proportion of immature gamma-delta T cells
        Decreased proportion of immature gamma-delta T cells
        Increased proportion of immature gamma-delta T cells
        Abnormal proportion of memory T cells
        Abnormal proportion of CD4-positive, alpha-beta memory T cells
        Abnormal proportion of CD4+ central memory cells
        Abnormal proportion of central memory CD4-positive, alpha-beta T cells
        Increased proportion of CD4-positive, alpha-beta memory T cells
        Abnormal proportion of CD8-positive, alpha-beta memory T cells
        Abnormal proportion of CD8-positive, alpha-beta TEMRA T cells
        Abnormal proportion of central memory CD8-positive, alpha-beta T cells
        Abnormal proportion of effector memory CD8-positive, alpha-beta T cells
        Increased proportion of CD8-positive, alpha-beta memory T cells
        Decreased proportion of memory T cells
        Decreased proportion of CD4-positive, alpha-beta memory T cells
        Decreased proportion of CD8-positive, alpha-beta memory T cells
        Increased proportion of memory T cells
        Abnormal proportion of naive T cells
        Abnormal proportion of naive CD4 T cells
        Decreased proportion of naive CD4 T cells
        Increased proportion of naive CD4 T cells
        Abnormal proportion of naive CD8 T cells
        Decreased proportion of naive T cells
        Decreased proportion of naive CD8 T cells
        Increased proportion of naive T cells
        Increased proportion of naive CD8 T cells
        Clonal T cell receptor rearrangement
        Decreased proportion of CD3-positive T cells
        Increased proportion of HLA DR+ T cells
        Reduced proportion of mucosal-associated invariant T cells

Professional guidelines

PubMed

Atopic dermatitis in children: clinical features, pathophysiology, and treatment.

Lyons JJ, Milner JD, Stone KD
Immunol Allergy Clin North Am 2015 Feb;35(1):161-83. Epub 2014 Nov 21 doi: 10.1016/j.iac.2014.09.008. PMID: 25459583 Free PMC Article

Mycosis fungoides and the Sézary syndrome: pathology, staging, and treatment.

Hoppe RT, Wood GS, Abel EA
Curr Probl Cancer 1990 Nov-Dec;14(6):293-371. doi: 10.1016/0147-0272(90)90018-l. PMID: 2245651

T lymphocyte subsets at various stages of hyperthyroid Graves' disease: effect of carbimazole treatment and relationship with thyroid-stimulating antibody levels or HLA status.

Madec AM, Allannic H, Genetet N, Gueguen M, Genetet G, Fauchet R, Stefanutti A, Orgiazzi J
J Clin Endocrinol Metab 1986 Jan;62(1):117-21. doi: 10.1210/jcem-62-1-117. PMID: 3484386

Recent clinical studies

Etiology

Peripheral blood and bone marrow lymphocyte subsets in patients with multiple myeloma.

Huang LQ, Tang JZ, Shen GX, Wang XL
J Tongji Med Univ 1990;10(2):73-6. doi: 10.1007/BF02887864. PMID: 2145443

T-cell functional abnormality in B-chronic lymphocytic leukaemia: evidence of a defect of the T-helper subset.

Lauria F, Foa R, Mantovani V, Fierro MT, Catovsky D, Tura S
Br J Haematol 1983 Jun;54(2):277-83. doi: 10.1111/j.1365-2141.1983.tb02096.x. PMID: 6221752

Clinical prediction guides

Peripheral blood and bone marrow lymphocyte subsets in patients with multiple myeloma.

Huang LQ, Tang JZ, Shen GX, Wang XL
J Tongji Med Univ 1990;10(2):73-6. doi: 10.1007/BF02887864. PMID: 2145443

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