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Prostate Intraductal Carcinoma

MedGen UID:
1687812
•Concept ID:
C5205726
•
Neoplastic Process
Synonyms: Intraductal Carcinoma of the Prostate; Intraductal Prostate Carcinoma

Definition

An intra-acinar and/or intraductal neoplastic epithelial proliferation in the prostate gland that has some features of high-grade prostatic intraepithelial neoplasia but exhibits much greater architectural and/or cytological atypia, typically associated with high-grade, high-stage prostate carcinoma. (WHO 2016) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Intraductal Carcinoma

Professional guidelines

PubMed

Current Understanding and Management of Intraductal Carcinoma of the Prostate.
Considine B, Adeniran A, Hurwitz ME
Curr Oncol Rep 2021 Jul 16;23(9):110. doi: 10.1007/s11912-021-01090-2. PMID: 34272624
The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.
Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179

Recent clinical studies

Etiology

Detection of intraductal carcinoma in prostate cancer patients with small tumor volume.
Takeshita N, Sakamoto S, Yamada Y, Sazuka T, Imamura Y, Komiya A, Akakura K, Sato N, Nakatsu H, Kato T, Sugimoto M, Tsuzuki T, Ichikawa T
Prostate 2023 May;83(6):580-589. Epub 2023 Feb 10 doi: 10.1002/pros.24492. PMID: 36762419
The Prognostic Value of the Proportion and Architectural Patterns of Intraductal Carcinoma of the Prostate in Patients with De Novo Metastatic Prostate Cancer.
Zhao J, Liu J, Sun G, Zhang M, Chen J, Shen P, Liu Z, Liao B, Zhang X, Gong J, Chen N, Zeng H; Collaborators
J Urol 2019 Apr;201(4):759-768. doi: 10.1016/j.juro.2018.10.016. PMID: 30652989
Clinicopathological analysis of intraductal proliferative lesions of prostate: intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion.
Miyai K, Divatia MK, Shen SS, Miles BJ, Ayala AG, Ro JY
Hum Pathol 2014 Aug;45(8):1572-81. Epub 2014 Apr 12 doi: 10.1016/j.humpath.2014.03.011. PMID: 24842280

Diagnosis

Intraductal carcinoma of the prostate.
Robinson B, Magi-Galluzzi C, Zhou M
Arch Pathol Lab Med 2012 Apr;136(4):418-25. doi: 10.5858/arpa.2011-0519-RA. PMID: 22458904

Prognosis

Detection of intraductal carcinoma in prostate cancer patients with small tumor volume.
Takeshita N, Sakamoto S, Yamada Y, Sazuka T, Imamura Y, Komiya A, Akakura K, Sato N, Nakatsu H, Kato T, Sugimoto M, Tsuzuki T, Ichikawa T
Prostate 2023 May;83(6):580-589. Epub 2023 Feb 10 doi: 10.1002/pros.24492. PMID: 36762419
The Prognostic Value of the Proportion and Architectural Patterns of Intraductal Carcinoma of the Prostate in Patients with De Novo Metastatic Prostate Cancer.
Zhao J, Liu J, Sun G, Zhang M, Chen J, Shen P, Liu Z, Liao B, Zhang X, Gong J, Chen N, Zeng H; Collaborators
J Urol 2019 Apr;201(4):759-768. doi: 10.1016/j.juro.2018.10.016. PMID: 30652989
Clinicopathological analysis of intraductal proliferative lesions of prostate: intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion.
Miyai K, Divatia MK, Shen SS, Miles BJ, Ayala AG, Ro JY
Hum Pathol 2014 Aug;45(8):1572-81. Epub 2014 Apr 12 doi: 10.1016/j.humpath.2014.03.011. PMID: 24842280
Intraductal carcinoma of the prostate.
Robinson B, Magi-Galluzzi C, Zhou M
Arch Pathol Lab Med 2012 Apr;136(4):418-25. doi: 10.5858/arpa.2011-0519-RA. PMID: 22458904

Clinical prediction guides

Detection of intraductal carcinoma in prostate cancer patients with small tumor volume.
Takeshita N, Sakamoto S, Yamada Y, Sazuka T, Imamura Y, Komiya A, Akakura K, Sato N, Nakatsu H, Kato T, Sugimoto M, Tsuzuki T, Ichikawa T
Prostate 2023 May;83(6):580-589. Epub 2023 Feb 10 doi: 10.1002/pros.24492. PMID: 36762419
The Prognostic Value of the Proportion and Architectural Patterns of Intraductal Carcinoma of the Prostate in Patients with De Novo Metastatic Prostate Cancer.
Zhao J, Liu J, Sun G, Zhang M, Chen J, Shen P, Liu Z, Liao B, Zhang X, Gong J, Chen N, Zeng H; Collaborators
J Urol 2019 Apr;201(4):759-768. doi: 10.1016/j.juro.2018.10.016. PMID: 30652989
Clinicopathological analysis of intraductal proliferative lesions of prostate: intraductal carcinoma of prostate, high-grade prostatic intraepithelial neoplasia, and atypical cribriform lesion.
Miyai K, Divatia MK, Shen SS, Miles BJ, Ayala AG, Ro JY
Hum Pathol 2014 Aug;45(8):1572-81. Epub 2014 Apr 12 doi: 10.1016/j.humpath.2014.03.011. PMID: 24842280

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