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Abnormal proportion of CD4+ central memory cells

MedGen UID:
1688200
•Concept ID:
C5139091
•
Finding
Synonym: Abnormal proportion of central memory CD4+, alpha-beta T cells
 
HPO: HP:0025620

Definition

An abnormal proportion of central memory CD4+ T cells. These are memory cells that are located in the secondary lymphoid organs. These cells may have a CD3/CD4/CD62L+/CD45RA- phenotype. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal proportion of CD4+ central memory cells

Recent clinical studies

Etiology

The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs.
Jiang C, Chi S, Wang F, Zhao C, Yang X, Liu M, Ma B, Chen J, Su C, Duan X
Immunobiology 2024 May;229(3):152798. Epub 2024 Mar 21 doi: 10.1016/j.imbio.2024.152798. PMID: 38537424
Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19.
Hocini H, Wiedemann A, Blengio F, Lefebvre C, Cervantes-Gonzalez M, Foucat E, Tisserand P, Surenaud M, Coléon S, Prague M, Guillaumat L, Krief C, Fenwick C, Laouénan C, Bouadma L, Ghosn J, Pantaleo G, Thiébaut R; French COVID cohort study group, Lévy Y
J Clin Immunol 2023 Jul;43(5):882-893. Epub 2023 Mar 21 doi: 10.1007/s10875-023-01459-x. PMID: 36943669Free PMC Article
T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice.
Vecchione A, Madley R, Danzl N, Borsotti C, Marharlooei MK, Li HW, Nauman G, Ding X, Ho SH, Fousteri G, Sykes M
Clin Immunol 2022 Jul;240:109048. Epub 2022 May 26 doi: 10.1016/j.clim.2022.109048. PMID: 35644520Free PMC Article
Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations.
Castro C, Oyamada HAA, Cafasso MOSD, Lopes LM, Monteiro C, Sacramento PM, Alves-Leon SV, da Fontoura Galvão G, Hygino J, de Souza JPBM, Bento CAM
J Neuroinflammation 2022 Feb 2;19(1):28. doi: 10.1186/s12974-022-02385-2. PMID: 35109870Free PMC Article

Diagnosis

CALM3 affects the prognosis of leukemia and hemorrhoids.
He J, Ni Z, Li Z
Medicine (Baltimore) 2023 Nov 3;102(44):e36027. doi: 10.1097/MD.0000000000036027. PMID: 37932969Free PMC Article
Clinical and Immunological Characterization of ICF Syndrome in Japan.
Kamae C, Imai K, Kato T, Okano T, Honma K, Nakagawa N, Yeh TW, Noguchi E, Ohara A, Shigemura T, Takahashi H, Takakura S, Hayashi M, Honma A, Watanabe S, Shigemori T, Ohara O, Sasaki H, Kubota T, Morio T, Kanegane H, Nonoyama S
J Clin Immunol 2018 Nov;38(8):927-937. Epub 2018 Oct 23 doi: 10.1007/s10875-018-0559-y. PMID: 30353301
Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95.
Carney EF, Srinivasan V, Moss PA, Taylor AM
J Immunol 2012 Jul 1;189(1):261-8. Epub 2012 May 30 doi: 10.4049/jimmunol.1101909. PMID: 22649200

Therapy

The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs.
Jiang C, Chi S, Wang F, Zhao C, Yang X, Liu M, Ma B, Chen J, Su C, Duan X
Immunobiology 2024 May;229(3):152798. Epub 2024 Mar 21 doi: 10.1016/j.imbio.2024.152798. PMID: 38537424
Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation.
Wang W, Liu L, Hui X, Wang Y, Ying W, Zhou Q, Hou J, Yang M, Sun B, Sun J, Wang X
BMC Immunol 2021 Mar 17;22(1):19. doi: 10.1186/s12865-021-00411-1. PMID: 33731004Free PMC Article

Prognosis

The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs.
Jiang C, Chi S, Wang F, Zhao C, Yang X, Liu M, Ma B, Chen J, Su C, Duan X
Immunobiology 2024 May;229(3):152798. Epub 2024 Mar 21 doi: 10.1016/j.imbio.2024.152798. PMID: 38537424
CALM3 affects the prognosis of leukemia and hemorrhoids.
He J, Ni Z, Li Z
Medicine (Baltimore) 2023 Nov 3;102(44):e36027. doi: 10.1097/MD.0000000000036027. PMID: 37932969Free PMC Article
Clinical and Immunological Characterization of ICF Syndrome in Japan.
Kamae C, Imai K, Kato T, Okano T, Honma K, Nakagawa N, Yeh TW, Noguchi E, Ohara A, Shigemura T, Takahashi H, Takakura S, Hayashi M, Honma A, Watanabe S, Shigemori T, Ohara O, Sasaki H, Kubota T, Morio T, Kanegane H, Nonoyama S
J Clin Immunol 2018 Nov;38(8):927-937. Epub 2018 Oct 23 doi: 10.1007/s10875-018-0559-y. PMID: 30353301

Clinical prediction guides

Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19.
Hocini H, Wiedemann A, Blengio F, Lefebvre C, Cervantes-Gonzalez M, Foucat E, Tisserand P, Surenaud M, Coléon S, Prague M, Guillaumat L, Krief C, Fenwick C, Laouénan C, Bouadma L, Ghosn J, Pantaleo G, Thiébaut R; French COVID cohort study group, Lévy Y
J Clin Immunol 2023 Jul;43(5):882-893. Epub 2023 Mar 21 doi: 10.1007/s10875-023-01459-x. PMID: 36943669Free PMC Article
Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations.
Castro C, Oyamada HAA, Cafasso MOSD, Lopes LM, Monteiro C, Sacramento PM, Alves-Leon SV, da Fontoura Galvão G, Hygino J, de Souza JPBM, Bento CAM
J Neuroinflammation 2022 Feb 2;19(1):28. doi: 10.1186/s12974-022-02385-2. PMID: 35109870Free PMC Article
Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cells.
Young TY, Jerome D, Gupta S
Ann Allergy Asthma Immunol 2007 Apr;98(4):389-92. doi: 10.1016/S1081-1206(10)60887-3. PMID: 17458437
Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance.
Miedema F
Immunodefic Rev 1992;3(3):173-93. PMID: 1354968

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