U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reduced proportion of CD4+ effector memory T cells

MedGen UID:
1690134
•Concept ID:
C5139095
•
Finding
Synonyms: Decreased proportion of CD4+ effector memory T cells; Decreased proportion of CD4-positive effector memory T cells; Decreased proportion of effector memory CD4-positive, alpha-beta T cells
 
HPO: HP:0025624

Definition

An abnormally decreased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced proportion of CD4+ effector memory T cells

Professional guidelines

PubMed

CD147 blockade as a potential and novel treatment of graft rejection.
Luan J, Zhao Y, Zhang Y, Miao J, Li J, Chen ZN, Zhu P
Mol Med Rep 2017 Oct;16(4):4593-4602. Epub 2017 Aug 9 doi: 10.3892/mmr.2017.7201. PMID: 28849101Free PMC Article
Current approaches to treatment for HIV-1 infection.
Powderly WG
J Neurovirol 2000 May;6 Suppl 1:S8-S13. PMID: 10871760

Recent clinical studies

Etiology

Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer.
Inomata M, Matsumoto M, Takata N, Hayashi K, Seto Z, Hirai T, Tokui K, Taka C, Okazawa S, Kambara K, Imanishi S, Miwa T, Hayashi R, Matsui S, Tobe K
Sci Rep 2023 Jul 4;13(1):10807. doi: 10.1038/s41598-023-37736-3. PMID: 37402763Free PMC Article
sLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells.
Silva M, Martin KC, Mondal N, Sackstein R
J Immunol 2020 Oct 1;205(7):1920-1932. Epub 2020 Aug 31 doi: 10.4049/jimmunol.1900679. PMID: 32868410Free PMC Article
Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study.
Bordoni V, Brando B, Piselli P, Forini O, Perna FE, Atripaldi U, Carputo S, Garziano F, Trento E, D'Agosto G, Latini A, Colafigli M, Cristaudo A, Sacchi A, Andreoni M, De Carli G, Orchi N, Grelli S, Gatti A, Cerva C, Minutolo A, Potestà M, Di Martino ML, Ortu F, Selva P, Del Pup L, Guarnori I, Lorenzini P, Capuano G, Antinori A, Agrati C
PLoS One 2019;14(12):e0225415. Epub 2019 Dec 23 doi: 10.1371/journal.pone.0225415. PMID: 31869342Free PMC Article
Differential immunomodulation of T-cells by immunoglobulin replacement therapy in primary and secondary antibody deficiency.
Dinh T, Oh J, Cameron DW, Lee SH, Cowan J
PLoS One 2019;14(10):e0223861. Epub 2019 Oct 15 doi: 10.1371/journal.pone.0223861. PMID: 31613907Free PMC Article
Characterization of CD4+ and CD8+ T Cell Subsets and Interferon Regulatory Factor 4 (IRF4) in MS Patients Treated with Fingolimod (FTY-720): A Follow-up Study.
Laribi B, Sahraian MA, Shekarabi M, Emamnejad R, Marzban M, Sadaghiani S, Izad M
Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):346-360. doi: 10.18502/ijaai.v17i4.94. PMID: 30537798

Diagnosis

Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer.
Inomata M, Matsumoto M, Takata N, Hayashi K, Seto Z, Hirai T, Tokui K, Taka C, Okazawa S, Kambara K, Imanishi S, Miwa T, Hayashi R, Matsui S, Tobe K
Sci Rep 2023 Jul 4;13(1):10807. doi: 10.1038/s41598-023-37736-3. PMID: 37402763Free PMC Article
CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant.
Yeh AC, Varelias A, Reddy A, Barone SM, Olver SD, Chilson K, Onstad LE, Ensbey KS, Henden AS, Samson L, Jaeger CA, Bi T, Dahlman KB, Kim TK, Zhang P, Degli-Esposti MA, Newell EW, Jagasia MH, Irish JM, Lee SJ, Hill GR
Blood 2021 Dec 30;138(26):2874-2885. doi: 10.1182/blood.2020009492. PMID: 34115118Free PMC Article
Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study.
Bordoni V, Brando B, Piselli P, Forini O, Perna FE, Atripaldi U, Carputo S, Garziano F, Trento E, D'Agosto G, Latini A, Colafigli M, Cristaudo A, Sacchi A, Andreoni M, De Carli G, Orchi N, Grelli S, Gatti A, Cerva C, Minutolo A, Potestà M, Di Martino ML, Ortu F, Selva P, Del Pup L, Guarnori I, Lorenzini P, Capuano G, Antinori A, Agrati C
PLoS One 2019;14(12):e0225415. Epub 2019 Dec 23 doi: 10.1371/journal.pone.0225415. PMID: 31869342Free PMC Article
Reduced CD4+ terminally differentiated effector memory T cells in moderate-severe house dust mites sensitized allergic rhinitis patients.
Sani MM, Ashari NSM, Abdullah B, Wong KK, Musa KI, Mohamud R, Tan HT
Asian Pac J Allergy Immunol 2019 Sep;37(3):138-146. doi: 10.12932/AP-191217-0220. PMID: 29981564
Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients.
Longbrake EE, Ramsbottom MJ, Cantoni C, Ghezzi L, Cross AH, Piccio L
Mult Scler 2016 Jul;22(8):1061-1070. Epub 2015 Oct 12 doi: 10.1177/1352458515608961. PMID: 26459150Free PMC Article

Therapy

Hydroxychloroquine reduces T cells activation recall antigen responses.
Kowatsch MM, Lajoie J, Mwangi L, Omollo K, Oyugi J, Hollett N, Kimani J, Fowke KR
PLoS One 2023;18(8):e0287738. Epub 2023 Aug 2 doi: 10.1371/journal.pone.0287738. PMID: 37531383Free PMC Article
Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer.
Inomata M, Matsumoto M, Takata N, Hayashi K, Seto Z, Hirai T, Tokui K, Taka C, Okazawa S, Kambara K, Imanishi S, Miwa T, Hayashi R, Matsui S, Tobe K
Sci Rep 2023 Jul 4;13(1):10807. doi: 10.1038/s41598-023-37736-3. PMID: 37402763Free PMC Article
CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant.
Yeh AC, Varelias A, Reddy A, Barone SM, Olver SD, Chilson K, Onstad LE, Ensbey KS, Henden AS, Samson L, Jaeger CA, Bi T, Dahlman KB, Kim TK, Zhang P, Degli-Esposti MA, Newell EW, Jagasia MH, Irish JM, Lee SJ, Hill GR
Blood 2021 Dec 30;138(26):2874-2885. doi: 10.1182/blood.2020009492. PMID: 34115118Free PMC Article
Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab.
Casneuf T, Adams HC 3rd, van de Donk NWCJ, Abraham Y, Bald J, Vanhoof G, Van der Borght K, Smets T, Foulk B, Nielsen KC, Rusbuldt J, Axel A, Lysaght A, Ceulemans H, Stevenaert F, Usmani SZ, Plesner T, Avet-Loiseau H, Nijhof I, Mutis T, Schecter JM, Chiu C, Bahlis NJ
Leukemia 2021 Feb;35(2):573-584. Epub 2020 May 26 doi: 10.1038/s41375-020-0855-4. PMID: 32457357Free PMC Article
Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.
Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S
J Virol 2020 Jan 17;94(3) doi: 10.1128/JVI.01270-19. PMID: 31723024Free PMC Article

Prognosis

Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer.
Inomata M, Matsumoto M, Takata N, Hayashi K, Seto Z, Hirai T, Tokui K, Taka C, Okazawa S, Kambara K, Imanishi S, Miwa T, Hayashi R, Matsui S, Tobe K
Sci Rep 2023 Jul 4;13(1):10807. doi: 10.1038/s41598-023-37736-3. PMID: 37402763Free PMC Article
CCND1 Amplification Profiling Identifies a Subtype of Melanoma Associated With Poor Survival and an Immunosuppressive Tumor Microenvironment.
Liu J, Lin J, Wang X, Zheng X, Gao X, Huang Y, Chen G, Xiong J, Lan B, Chen C, Si L, Chen Y
Front Immunol 2022;13:725679. Epub 2022 Jul 1 doi: 10.3389/fimmu.2022.725679. PMID: 35844619Free PMC Article
Blood T-cell profiling in metastatic melanoma patients as a marker for response to immune checkpoint inhibitors combined with radiotherapy.
Ratnayake G, Reinwald S, Edwards J, Wong N, Yu D, Ward R, Smith R, Haydon A, Au PM, van Zelm MC, Senthi S
Radiother Oncol 2022 Aug;173:299-305. Epub 2022 Jun 27 doi: 10.1016/j.radonc.2022.06.016. PMID: 35772575
Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study.
Bordoni V, Brando B, Piselli P, Forini O, Perna FE, Atripaldi U, Carputo S, Garziano F, Trento E, D'Agosto G, Latini A, Colafigli M, Cristaudo A, Sacchi A, Andreoni M, De Carli G, Orchi N, Grelli S, Gatti A, Cerva C, Minutolo A, Potestà M, Di Martino ML, Ortu F, Selva P, Del Pup L, Guarnori I, Lorenzini P, Capuano G, Antinori A, Agrati C
PLoS One 2019;14(12):e0225415. Epub 2019 Dec 23 doi: 10.1371/journal.pone.0225415. PMID: 31869342Free PMC Article
Characterization of CD4+ and CD8+ T Cell Subsets and Interferon Regulatory Factor 4 (IRF4) in MS Patients Treated with Fingolimod (FTY-720): A Follow-up Study.
Laribi B, Sahraian MA, Shekarabi M, Emamnejad R, Marzban M, Sadaghiani S, Izad M
Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):346-360. doi: 10.18502/ijaai.v17i4.94. PMID: 30537798

Clinical prediction guides

Hydroxychloroquine reduces T cells activation recall antigen responses.
Kowatsch MM, Lajoie J, Mwangi L, Omollo K, Oyugi J, Hollett N, Kimani J, Fowke KR
PLoS One 2023;18(8):e0287738. Epub 2023 Aug 2 doi: 10.1371/journal.pone.0287738. PMID: 37531383Free PMC Article
Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer.
Inomata M, Matsumoto M, Takata N, Hayashi K, Seto Z, Hirai T, Tokui K, Taka C, Okazawa S, Kambara K, Imanishi S, Miwa T, Hayashi R, Matsui S, Tobe K
Sci Rep 2023 Jul 4;13(1):10807. doi: 10.1038/s41598-023-37736-3. PMID: 37402763Free PMC Article
CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant.
Yeh AC, Varelias A, Reddy A, Barone SM, Olver SD, Chilson K, Onstad LE, Ensbey KS, Henden AS, Samson L, Jaeger CA, Bi T, Dahlman KB, Kim TK, Zhang P, Degli-Esposti MA, Newell EW, Jagasia MH, Irish JM, Lee SJ, Hill GR
Blood 2021 Dec 30;138(26):2874-2885. doi: 10.1182/blood.2020009492. PMID: 34115118Free PMC Article
Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19.
Yang J, Zhong M, Zhang E, Hong K, Yang Q, Zhou D, Xia J, Chen YQ, Sun M, Zhao B, Xiang J, Liu Y, Han Y, Xu M, Zhou X, Huang C, Shang Y, Yan H
J Mol Cell Biol 2021 Jul 6;13(3):197-209. doi: 10.1093/jmcb/mjab014. PMID: 33751111Free PMC Article
Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis.
Kadowaki A, Saga R, Lin Y, Sato W, Yamamura T
Brain 2019 Apr 1;142(4):916-931. doi: 10.1093/brain/awz012. PMID: 30770703Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...