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Decreased circulating IgG subclass level

MedGen UID:
1691048
•Concept ID:
C5139655
•
Finding
Synonym: Decreased IgG subclass level in blood
 
HPO: HP:0032135

Definition

A reduction below the normal concentration of a subclass of immunoglobulin G (IgG) in the blood. [from HPO]

Professional guidelines

PubMed

Long-term persistence of anti-factor VIII antibody-secreting cells in hemophilic mice after treatment with human factor VIII.
Hausl C, Maier E, Schwarz HP, Ahmad RU, Turecek PL, Dorner F, Reipert BM
Thromb Haemost 2002 May;87(5):840-5. PMID: 12038787

Recent clinical studies

Etiology

New insight of human-IgH 3'regulatory regions in immunoglobulins switch.
Cianci R, Mancino G, Galli E, Serone E, Massoud R, D'Addabbo P, Poscia A, Borghetti A, Porzio O, Marmo R, Gambassi G, Frezza D
Gene 2023 Apr 30;862:147254. Epub 2023 Feb 9 doi: 10.1016/j.gene.2023.147254. PMID: 36764340
Factors influencing the immune response over 15 months after SARS-CoV-2 infection: A longitudinal population-wide study in the Faroe Islands.
Petersen MS, Pérez-Alós L, Armenteros JJA, Hansen CB, Fjallsbak JP, Larsen S, Hansen JL, Jarlhelt I, Kristiansen MF, Við Streym F, Á Steig B, Christiansen DH, Møller LF, Strøm M, Andorsdóttir G, Gaini S, Weihe P, Garred P
J Intern Med 2023 Jan;293(1):63-81. Epub 2022 Sep 1 doi: 10.1111/joim.13560. PMID: 35996938Free PMC Article
Mumps-specific IgG, IgG subclasses and neutralization titres to the vaccine and outbreak mumps strains differ in vaccinated healthy controls, breakthrough mumps infection cases and naturally infected individuals.
Foley DJ, Connell AR, Gonzalez G, Connell J, Leahy TR, De Gascun C, Hassan J
J Clin Virol 2022 Dec;157:105296. Epub 2022 Sep 21 doi: 10.1016/j.jcv.2022.105296. PMID: 36209622
The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives.
Bogaert DJ, De Bruyne M, Debacker V, Depuydt P, De Preter K, Bonroy C, Philippé J, Bordon V, Lambrecht BN, Kerre T, Cerutti A, Vermaelen KY, Haerynck F, Dullaers M
Haematologica 2017 Jan;102(1):192-202. Epub 2016 Sep 15 doi: 10.3324/haematol.2016.149112. PMID: 27634199Free PMC Article
IgG subclass distribution and relative functional affinity of anti-myeloperoxidase antibodies in systemic vasculitis at presentation and during follow-up.
Esnault VL, Jayne DR, Weetman AP, Lockwood CM
Immunology 1991 Dec;74(4):714-8. PMID: 1664417Free PMC Article

Diagnosis

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives.
Bogaert DJ, De Bruyne M, Debacker V, Depuydt P, De Preter K, Bonroy C, Philippé J, Bordon V, Lambrecht BN, Kerre T, Cerutti A, Vermaelen KY, Haerynck F, Dullaers M
Haematologica 2017 Jan;102(1):192-202. Epub 2016 Sep 15 doi: 10.3324/haematol.2016.149112. PMID: 27634199Free PMC Article
Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis.
Orfali RL, Sato MN, Santos VG, Titz TO, Brito CA, Duarte AJ, Takaoka R, Aoki V
Int J Dermatol 2015 Aug;54(8):898-904. Epub 2014 Oct 14 doi: 10.1111/ijd.12533. PMID: 25312705
Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia.
Pal S, Bandyopadhyay S, Chatterjee M, Bhattacharya DK, Minto L, Hall AG, Mandal C
Clin Biochem 2004 May;37(5):395-403. doi: 10.1016/j.clinbiochem.2004.01.001. PMID: 15087256
Decreased cytokine-induced IgA subclass production by CD40-ligated circulating B cells in primary IgA nephropathy.
de Fijter JW, van Nisselrooij NI, Schroeijers WE, Daha MR, van Es LA, van Kooten C
Nephrol Dial Transplant 1998 Feb;13(2):285-92. PMID: 9509436
Diagnosis and immunotherapy of mould allergy. VII. IgG subclass response and relation to the clinical efficacy of immunotherapy with Cladosporium.
Malling HJ, Djurup R
Allergy 1988 Jan;43(1):60-70. doi: 10.1111/j.1398-9995.1988.tb02045.x. PMID: 3344936

Therapy

Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia.
Pal S, Bandyopadhyay S, Chatterjee M, Bhattacharya DK, Minto L, Hall AG, Mandal C
Clin Biochem 2004 May;37(5):395-403. doi: 10.1016/j.clinbiochem.2004.01.001. PMID: 15087256
Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia.
Kano Y, Inaoka M, Shiohara T
Arch Dermatol 2004 Feb;140(2):183-8. doi: 10.1001/archderm.140.2.183. PMID: 14967790
Recombinant interleukin-2 infusions and decreased IgG2 subclass concentrations.
Soiffer RJ, Murray C, Ritz J, Phillips N, Jacobsohn D, Chartier S, Ambrosino DM
Blood 1995 Feb 15;85(4):925-8. PMID: 7849314
Evidence for differential effects of sulphasalazine on systemic and mucosal immunity in rheumatoid arthritis.
Kanerud L, Engström GN, Tarkowski A
Ann Rheum Dis 1995 Apr;54(4):256-62. doi: 10.1136/ard.54.4.256. PMID: 7763101Free PMC Article
Diagnosis and immunotherapy of mould allergy. VII. IgG subclass response and relation to the clinical efficacy of immunotherapy with Cladosporium.
Malling HJ, Djurup R
Allergy 1988 Jan;43(1):60-70. doi: 10.1111/j.1398-9995.1988.tb02045.x. PMID: 3344936

Prognosis

Natural antibody response to Plasmodium falciparum merozoite antigens MSP5, MSP9 and EBA175 is associated to clinical protection in the Brazilian Amazon.
Medeiros MM, Fotoran WL, dalla Martha RC, Katsuragawa TH, Pereira da Silva LH, Wunderlich G
BMC Infect Dis 2013 Dec 28;13:608. doi: 10.1186/1471-2334-13-608. PMID: 24373342Free PMC Article
Antibodies against 9-O-acetylated sialoglycans: a potent marker to monitor clinical status in childhood acute lymphoblastic leukemia.
Pal S, Bandyopadhyay S, Chatterjee M, Bhattacharya DK, Minto L, Hall AG, Mandal C
Clin Biochem 2004 May;37(5):395-403. doi: 10.1016/j.clinbiochem.2004.01.001. PMID: 15087256
Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia.
Kano Y, Inaoka M, Shiohara T
Arch Dermatol 2004 Feb;140(2):183-8. doi: 10.1001/archderm.140.2.183. PMID: 14967790
IgG4 and IgE are the major immunoglobulins targeting the NC16A domain of BP180 in Bullous pemphigoid: serum levels of these immunoglobulins reflect disease activity.
Döpp R, Schmidt E, Chimanovitch I, Leverkus M, Bröcker EB, Zillikens D
J Am Acad Dermatol 2000 Apr;42(4):577-83. PMID: 10727301
IgG subclass distribution and relative functional affinity of anti-myeloperoxidase antibodies in systemic vasculitis at presentation and during follow-up.
Esnault VL, Jayne DR, Weetman AP, Lockwood CM
Immunology 1991 Dec;74(4):714-8. PMID: 1664417Free PMC Article

Clinical prediction guides

Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre- and end-stage heart failure.
van den Hoogen P, de Jager SCA, Huibers MMH, Schoneveld AH, Puspitasari YM, Valstar GB, Oerlemans MIFJ, de Weger RA, Doevendans PA, den Ruijter HM, Laman JD, Vink A, Sluijter JPG
J Cell Mol Med 2019 Nov;23(11):7505-7516. Epub 2019 Sep 26 doi: 10.1111/jcmm.14619. PMID: 31557411Free PMC Article
Does class switching contribute to remission in bullous pemphigoid?
Modre B, Allen J, Wojnarowska F
Acta Derm Venereol 1999 Mar;79(2):127-31. doi: 10.1080/000155599750011345. PMID: 10228631
Evolution of maternofetal transport of immunoglobulins during human pregnancy.
Malek A, Sager R, Kuhn P, Nicolaides KH, Schneider H
Am J Reprod Immunol 1996 Nov;36(5):248-55. doi: 10.1111/j.1600-0897.1996.tb00172.x. PMID: 8955500
Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population.
Paganelli R, Quinti I, Fagiolo U, Cossarizza A, Ortolani C, Guerra E, Sansoni P, Pucillo LP, Scala E, Cozzi E
Clin Exp Immunol 1992 Nov;90(2):351-4. doi: 10.1111/j.1365-2249.1992.tb07954.x. PMID: 1424294Free PMC Article
Diagnosis and immunotherapy of mould allergy. VII. IgG subclass response and relation to the clinical efficacy of immunotherapy with Cladosporium.
Malling HJ, Djurup R
Allergy 1988 Jan;43(1):60-70. doi: 10.1111/j.1398-9995.1988.tb02045.x. PMID: 3344936

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