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Transient decreased circulating IgG4

MedGen UID:
1729050
•Concept ID:
C5421690
•
Finding
Synonym: Transient decreased IgG4 in blood
 
HPO: HP:0041057

Definition

A temporary reduction beneath the normal level of total immunoglobulin G4 (IgG4) in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient decreased circulating IgG4

Recent clinical studies

Etiology

Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS project.
Mageau A, Tchen J, Ferré VM, Nicaise-Roland P, Descamps D, Delory N, François C, Mendes C, Papo T, Goulenok T, Charles N, Sacré K
J Autoimmun 2023 Jan;134:102987. Epub 2022 Dec 19 doi: 10.1016/j.jaut.2022.102987. PMID: 36563528Free PMC Article
High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life.
Tomicić S, Norrman G, Fälth-Magnusson K, Jenmalm MC, Devenney I, Böttcher MF
Pediatr Allergy Immunol 2009 Feb;20(1):35-41. Epub 2008 Mar 12 doi: 10.1111/j.1399-3038.2008.00738.x. PMID: 18346097
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency.
Kowalczyk D, Mytar B, Zembala M
J Allergy Clin Immunol 1997 Oct;100(4):556-62. doi: 10.1016/s0091-6749(97)70150-7. PMID: 9338552
Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment.
Berchtold P, Wenger M
Blood 1993 Mar 1;81(5):1246-50. PMID: 8443385
Surfactant proteins and anti-surfactant antibodies in sera from infants with respiratory distress syndrome with and without surfactant treatment.
Chida S, Phelps DS, Soll RF, Taeusch HW
Pediatrics 1991 Jul;88(1):84-9. PMID: 2057277

Diagnosis

Immune-mediated etiology of acquired von Willebrand syndrome in systemic lupus erythematosus and in benign monoclonal gammopathy: therapeutic implications.
Michiels JJ, Berneman Z, Gadisseur A, van der Planken M, Schroyens W, Budde U, van Vliet HH
Semin Thromb Hemost 2006 Sep;32(6):577-88. doi: 10.1055/s-2006-949663. PMID: 16977568
Mild endotoxaemia and the inflammatory response induced by a marathon race.
Camus G, Poortmans J, Nys M, Deby-Dupont G, Duchateau J, Deby C, Lamy M
Clin Sci (Lond) 1997 Apr;92(4):415-22. doi: 10.1042/cs0920415. PMID: 9176042
Sequential anti-core glycolipid immunoglobulin antibody activities in patients with and without septic shock and their relation to outcome.
Nys M, Damas P, Joassin L, Lamy M
Ann Surg 1993 Mar;217(3):300-6. doi: 10.1097/00000658-199303000-00013. PMID: 8452409Free PMC Article

Therapy

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors.
Strauss J, Heery CR, Kim JW, Jochems C, Donahue RN, Montgomery AS, McMahon S, Lamping E, Marté JL, Madan RA, Bilusic M, Silver MR, Bertotti E, Schlom J, Gulley JL
Clin Cancer Res 2019 Jan 1;25(1):99-109. Epub 2018 Aug 21 doi: 10.1158/1078-0432.CCR-18-1512. PMID: 30131389Free PMC Article
Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
Richards DB, Cookson LM, Berges AC, Barton SV, Lane T, Ritter JM, Fontana M, Moon JC, Pinzani M, Gillmore JD, Hawkins PN, Pepys MB
N Engl J Med 2015 Sep 17;373(12):1106-14. Epub 2015 Jul 15 doi: 10.1056/NEJMoa1504942. PMID: 26176329
High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life.
Tomicić S, Norrman G, Fälth-Magnusson K, Jenmalm MC, Devenney I, Böttcher MF
Pediatr Allergy Immunol 2009 Feb;20(1):35-41. Epub 2008 Mar 12 doi: 10.1111/j.1399-3038.2008.00738.x. PMID: 18346097
Neutropenia as a complication of high-dose intravenous immunoglobulin therapy in adult patients with neuroimmunologic disorders.
Matsuda M, Hosoda W, Sekijima Y, Hoshi K, Hashimoto T, Itoh S, Ikeda S
Clin Neuropharmacol 2003 Nov-Dec;26(6):306-11. doi: 10.1097/00002826-200311000-00009. PMID: 14646610
Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment.
Berchtold P, Wenger M
Blood 1993 Mar 1;81(5):1246-50. PMID: 8443385

Prognosis

Humoral immune response against tumoral mucin 1 (MUC1) in breast cancer patients.
Isla Larrain MT, Colussi AG, Demichelis SO, Barbera A, Cretón A, Segal-Eiras A, Croce MV
Int J Biol Markers 2013 Sep 27;28(3):318-25. doi: 10.5301/jbm.5000036. PMID: 23828406
Experience with protein A-immunoadsorption in treatment-resistant adult immune thrombocytopenic purpura.
Snyder HW Jr, Cochran SK, Balint JP Jr, Bertram JH, Mittelman A, Guthrie TH Jr, Jones FR
Blood 1992 May 1;79(9):2237-45. PMID: 1571540
Recurrent nephrotic syndrome following renal transplantation in patients with focal glomerulosclerosis. A one-center study of plasma exchange effects.
Dantal J, Baatard R, Hourmant M, Cantarovich D, Buzelin F, Soulillou JP
Transplantation 1991 Nov;52(5):827-31. doi: 10.1097/00007890-199111000-00014. PMID: 1949168
Studies on circulating immune complexes. III: Kinetics of the immunoglobulin class of circulating immune complexes in systemic lupus erythematosus.
Miura Y
Nihon Jinzo Gakkai Shi 1989 Feb;31(2):201-9. PMID: 2739119
Characterization of antihuman chorionic gonadotropin serum antibody appearing after ovulation induction.
Braunstein GD, Bloch SK, Rasor JL, Winikoff J
J Clin Endocrinol Metab 1983 Dec;57(6):1164-72. doi: 10.1210/jcem-57-6-1164. PMID: 6630412

Clinical prediction guides

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors.
Strauss J, Heery CR, Kim JW, Jochems C, Donahue RN, Montgomery AS, McMahon S, Lamping E, Marté JL, Madan RA, Bilusic M, Silver MR, Bertotti E, Schlom J, Gulley JL
Clin Cancer Res 2019 Jan 1;25(1):99-109. Epub 2018 Aug 21 doi: 10.1158/1078-0432.CCR-18-1512. PMID: 30131389Free PMC Article
Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
Richards DB, Cookson LM, Berges AC, Barton SV, Lane T, Ritter JM, Fontana M, Moon JC, Pinzani M, Gillmore JD, Hawkins PN, Pepys MB
N Engl J Med 2015 Sep 17;373(12):1106-14. Epub 2015 Jul 15 doi: 10.1056/NEJMoa1504942. PMID: 26176329
Cytokine production in transient hypogammaglobulinemia and isolated IgA deficiency.
Kowalczyk D, Mytar B, Zembala M
J Allergy Clin Immunol 1997 Oct;100(4):556-62. doi: 10.1016/s0091-6749(97)70150-7. PMID: 9338552
Mild endotoxaemia and the inflammatory response induced by a marathon race.
Camus G, Poortmans J, Nys M, Deby-Dupont G, Duchateau J, Deby C, Lamy M
Clin Sci (Lond) 1997 Apr;92(4):415-22. doi: 10.1042/cs0920415. PMID: 9176042
Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia.
Klein B, Wijdenes J, Zhang XG, Jourdan M, Boiron JM, Brochier J, Liautard J, Merlin M, Clement C, Morel-Fournier B
Blood 1991 Sep 1;78(5):1198-204. PMID: 1715218

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