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Abnormal plasma cell count

MedGen UID:
1692593
•Concept ID:
C5139088
•
Finding
HPO: HP:0025617

Definition

An abnormal number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies. [from HPO]

Professional guidelines

PubMed

Multiple Myeloma: Diagnosis and Treatment.
Michels TC, Petersen KE
Am Fam Physician 2017 Mar 15;95(6):373-383. PMID: 28318212
Multiple myeloma: from diagnosis to treatment.
Eslick R, Talaulikar D
Aust Fam Physician 2013 Oct;42(10):684-8. PMID: 24130968
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007

Recent clinical studies

Etiology

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
The Efficacy and Safety of Plasma Exchange in the Treatment of Thrombotic Thrombocytopenic Purpura.
Pan Z, Zhang Z, Yang Y, Hao W
J Healthc Eng 2022;2022:3519937. Epub 2022 Mar 31 doi: 10.1155/2022/3519937. PMID: 35399835Free PMC Article
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
Strategies for transfusion therapy.
Spahn DR
Best Pract Res Clin Anaesthesiol 2004 Dec;18(4):661-73. doi: 10.1016/j.bpa.2004.05.002. PMID: 15460551
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Diagnosis

Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA.
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM
Nat Med 2019 Mar;25(3):439-447. Epub 2019 Jan 28 doi: 10.1038/s41591-018-0334-x. PMID: 30692697
Multiple Myeloma: Diagnosis and Treatment.
Michels TC, Petersen KE
Am Fam Physician 2017 Mar 15;95(6):373-383. PMID: 28318212
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874
Neurosyphilis.
Kolar OJ, Burkhart JE
Br J Vener Dis 1977 Aug;53(4):221-5. doi: 10.1136/sti.53.4.221. PMID: 336144Free PMC Article

Therapy

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
The Efficacy and Safety of Plasma Exchange in the Treatment of Thrombotic Thrombocytopenic Purpura.
Pan Z, Zhang Z, Yang Y, Hao W
J Healthc Eng 2022;2022:3519937. Epub 2022 Mar 31 doi: 10.1155/2022/3519937. PMID: 35399835Free PMC Article
The T Cell in Myeloma.
Joshua D, Suen H, Brown R, Bryant C, Ho PJ, Hart D, Gibson J
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):537-542. Epub 2016 Aug 10 doi: 10.1016/j.clml.2016.08.003. PMID: 27601001
T-Cell Abnormalities in Common Variable Immunodeficiency.
Azizi G, Rezaei N, Kiaee F, Tavakolinia N, Yazdani R, Mirshafiey A, Aghamohammadi A
J Investig Allergol Clin Immunol 2016;26(4):233-43. Epub 2016 Apr 15 doi: 10.18176/jiaci.0069. PMID: 27374799
Nodular cutaneous amyloidosis.
Borowicz J, Shama L, Miller R
Skinmed 2011 Sep-Oct;9(5):316-8. PMID: 22165048

Prognosis

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA.
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM
Nat Med 2019 Mar;25(3):439-447. Epub 2019 Jan 28 doi: 10.1038/s41591-018-0334-x. PMID: 30692697
Plasma cell morphology in multiple myeloma and related disorders.
Ribourtout B, Zandecki M
Morphologie 2015 Jun;99(325):38-62. Epub 2015 Apr 18 doi: 10.1016/j.morpho.2015.02.001. PMID: 25899140
Unexplained macrocytosis.
Younes M, Dagher GA, Dulanto JV, Njeim M, Kuriakose P
South Med J 2013 Feb;106(2):121-5. doi: 10.1097/SMJ.0b013e3182824cdf. PMID: 23380746
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Clinical prediction guides

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
The Efficacy and Safety of Plasma Exchange in the Treatment of Thrombotic Thrombocytopenic Purpura.
Pan Z, Zhang Z, Yang Y, Hao W
J Healthc Eng 2022;2022:3519937. Epub 2022 Mar 31 doi: 10.1155/2022/3519937. PMID: 35399835Free PMC Article
Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA.
Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM
Nat Med 2019 Mar;25(3):439-447. Epub 2019 Jan 28 doi: 10.1038/s41591-018-0334-x. PMID: 30692697
Plasma cell morphology in multiple myeloma and related disorders.
Ribourtout B, Zandecki M
Morphologie 2015 Jun;99(325):38-62. Epub 2015 Apr 18 doi: 10.1016/j.morpho.2015.02.001. PMID: 25899140
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Recent systematic reviews

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Association of antiretroviral therapy with anal high-risk human papillomavirus, anal intraepithelial neoplasia, and anal cancer in people living with HIV: a systematic review and meta-analysis.
Kelly H, Chikandiwa A, Alemany Vilches L, Palefsky JM, de Sanjose S, Mayaud P
Lancet HIV 2020 Apr;7(4):e262-e278. Epub 2020 Feb 25 doi: 10.1016/S2352-3018(19)30434-5. PMID: 32109408
Disseminated malignancy misdiagnosed as thrombotic thrombocytopenic purpura: A report of 10 patients and a systematic review of published cases.
Francis KK, Kalyanam N, Terrell DR, Vesely SK, George JN
Oncologist 2007 Jan;12(1):11-9. doi: 10.1634/theoncologist.12-1-11. PMID: 17227897

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