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Advanced Adenocarcinoma

MedGen UID:
1693607
•Concept ID:
C5204526
•
Neoplastic Process

Definition

An adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adenocarcinoma

Professional guidelines

PubMed

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Recent clinical studies

Etiology

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Comparison of the immunotherapy efficacy between invasive mucinous and non-mucinous adenocarcinoma in advanced lung cancer patients with KRAS mutation: a retrospective study.
Xu M, Hao Y, Zhou H, Shi Z, Si J, Song Z
Med Oncol 2023 Jun 9;40(7):198. doi: 10.1007/s12032-023-02059-w. PMID: 37294384
Short-term outcome of Ivor Lewis esophagectomy following neoadjuvant chemoradiation versus perioperative chemotherapy in patients with locally advanced adenocarcinoma of the esophagus and gastroesophageal junction: a propensity score-matched analysis.
Plum PS, Damanakis A, Buschmann L, Ernst A, Datta RR, Schiffmann LM, Zander T, Fuchs H, Chon SH, Alakus H, Schröder W, Hölscher AH, Bruns CJ, Bludau M
J Cancer Res Clin Oncol 2022 May;148(5):1223-1234. Epub 2021 Jul 5 doi: 10.1007/s00432-021-03720-5. PMID: 34223965Free PMC Article
Molecular-targeted first-line therapy for advanced gastric cancer.
Song H, Zhu J, Lu D
Cochrane Database Syst Rev 2016 Jul 19;7(7):CD011461. doi: 10.1002/14651858.CD011461.pub2. PMID: 27432490Free PMC Article
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Diagnosis

Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Biomarkers for Selection of Therapy for Adenocarcinoma of the Lung.
Bernicker EH, Miller RA, Cagle PT
J Oncol Pract 2017 Apr;13(4):221-227. doi: 10.1200/JOP.2016.019182. PMID: 28399384
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Pathology of lung cancer.
Travis WD
Clin Chest Med 2011 Dec;32(4):669-92. doi: 10.1016/j.ccm.2011.08.005. PMID: 22054879
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Therapy

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junction.
Tang Z, Wang Y, Liu D, Wang X, Xu C, Yu Y, Cui Y, Tang C, Li Q, Sun J, Zhang Q, Ji Y, Ma G, Li H, Shen Z, Shen K, Zheng R, Hou Z, Liu T, Wang J, Sun Y
Nat Commun 2022 Nov 10;13(1):6807. doi: 10.1038/s41467-022-34403-5. PMID: 36357415Free PMC Article
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study.
Türeci O, Sahin U, Schulze-Bergkamen H, Zvirbule Z, Lordick F, Koeberle D, Thuss-Patience P, Ettrich T, Arnold D, Bassermann F, Al-Batran SE, Wiechen K, Dhaene K, Maurus D, Gold M, Huber C, Krivoshik A, Arozullah A, Park JW, Schuler M
Ann Oncol 2019 Sep 1;30(9):1487-1495. doi: 10.1093/annonc/mdz199. PMID: 31240302Free PMC Article
Antiangiogenic Therapy in Gastroesophageal Cancer.
Jin Z, Yoon HH
Hematol Oncol Clin North Am 2017 Jun;31(3):499-510. Epub 2017 Mar 22 doi: 10.1016/j.hoc.2017.01.008. PMID: 28501090

Prognosis

Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Biomarkers for Selection of Therapy for Adenocarcinoma of the Lung.
Bernicker EH, Miller RA, Cagle PT
J Oncol Pract 2017 Apr;13(4):221-227. doi: 10.1200/JOP.2016.019182. PMID: 28399384
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Barrett's esophagus.
Bird-Lieberman EL, Fitzgerald RC
Gastroenterol Clin North Am 2008 Dec;37(4):921-42, x. doi: 10.1016/j.gtc.2008.09.003. PMID: 19028325

Clinical prediction guides

A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma.
Tan TJ, Ang WXG, Wang WW, Chong HS, Tan SH, Cheong R, Chia JW, Syn NL, Shuen WH, Ba R, Kaliaperumal N, Au B, Hopkins R, Li X, Tan AC, Seet AOL, Connolly JE, Arkachaisri T, Chew V, Lajam ABM, Guo D, Chew MZW, Wasser M, Kumar P, Albani S, Toh HC
Nat Commun 2022 Oct 28;13(1):6453. doi: 10.1038/s41467-022-33834-4. PMID: 36307410Free PMC Article
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Tissue and Blood Biomarkers in Lung Cancer: A Review.
Duffy MJ, O'Byrne K
Adv Clin Chem 2018;86:1-21. Epub 2018 May 30 doi: 10.1016/bs.acc.2018.05.001. PMID: 30144837
Biomarkers for Selection of Therapy for Adenocarcinoma of the Lung.
Bernicker EH, Miller RA, Cagle PT
J Oncol Pract 2017 Apr;13(4):221-227. doi: 10.1200/JOP.2016.019182. PMID: 28399384
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472

Recent systematic reviews

Prevalence of highly actionable mutations among Indian patients with advanced non-small cell lung cancer: A systematic review and meta-analysis.
Raman R, Ramamohan V, Rathore A, Jain D, Mohan A, Vashistha V
Asia Pac J Clin Oncol 2023 Feb;19(1):158-171. Epub 2022 May 30 doi: 10.1111/ajco.13802. PMID: 35634796
Molecular-targeted first-line therapy for advanced gastric cancer.
Song H, Zhu J, Lu D
Cochrane Database Syst Rev 2016 Jul 19;7(7):CD011461. doi: 10.1002/14651858.CD011461.pub2. PMID: 27432490Free PMC Article
Endoscopic stenting for gastric outlet obstruction in patients with unresectable antro pyloric cancer. Systematic review of the literature and final results of a prospective study. The point of view of a surgical group.
Fiori E, Lamazza A, Demasi E, Decesare A, Schillaci A, Sterpetti AV
Am J Surg 2013 Aug;206(2):210-7. Epub 2013 Jun 2 doi: 10.1016/j.amjsurg.2012.08.018. PMID: 23735668
Short versus long duration infusions of paclitaxel for any advanced adenocarcinoma.
Williams C, Bryant A
Cochrane Database Syst Rev 2011 May 11;2011(5):CD003911. doi: 10.1002/14651858.CD003911.pub2. PMID: 21563139Free PMC Article
Short versus long duration infusions of paclitaxel for any adenocarcinoma.
Williams C, Collingwood M, Simera I, Grafton C
Cochrane Database Syst Rev 2003;(1):CD003911. doi: 10.1002/14651858.CD003911. PMID: 12535492

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