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Advanced Endometrial Adenocarcinoma

MedGen UID:
1737281
•Concept ID:
C5418809
•
Neoplastic Process
Synonyms: Advanced Endometrial Adenocarcinoma, NOS; Advanced Endometrial Adenocarcinoma, Not Otherwise Specified

Definition

Endometrial adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Endometrial Adenocarcinoma

Professional guidelines

PubMed

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Therapeutic targeting of the TNF superfamily: a promising treatment for advanced endometrial adenocarcinoma.
Thangaraju S, Subramani E, Chakravarty B, Chaudhury K
Gynecol Oncol 2012 Nov;127(2):426-32. Epub 2012 Aug 7 doi: 10.1016/j.ygyno.2012.07.125. PMID: 22885470
Treatment of advanced endometrial adenocarcinoma with a combined cytotoxic therapy. Predictive value of cytosol estrogen and progestin receptor levels.
Kauppila A, Jänne O, Kujansuu E, Vihko R
Cancer 1980 Nov 15;46(10):2162-7. doi: 10.1002/1097-0142(19801115)46:10<2162::aid-cncr2820461010>3.0.co;2-v. PMID: 6253041

Recent clinical studies

Etiology

Paclitaxel/carboplatin versus cyclophosphamide/adriamycin/cisplatin as postoperative adjuvant chemotherapy for advanced endometrial adenocarcinoma.
Hidaka T, Nakamura T, Shima T, Yuki H, Saito S
J Obstet Gynaecol Res 2006 Jun;32(3):330-7. doi: 10.1111/j.1447-0756.2006.00405.x. PMID: 16764625
Splenic metastases in gynaecologic cancer: clinical considerations, US, and CT diagnostic results.
La Fianza A, Madonia L
Radiol Med 2003 Jul-Aug;106(1-2):36-43. PMID: 12951549
Cisplatin, adriamycin, etoposide, megestrol acetate versus melphalan, 5-fluorouracil, medroxyprogesterone acetate in the treatment of endometrial carcinoma.
Cornelison TL, Baker TR, Piver MS, Driscoll DL
Gynecol Oncol 1995 Nov;59(2):243-8. doi: 10.1006/gyno.1995.0015. PMID: 7590480
Tamoxifen and medroxyprogesterone therapy for advanced endometrial carcinoma.
Rendina GM, Donadio C, Fabri M, Mazzoni P, Nazzicone P
Eur J Obstet Gynecol Reprod Biol 1984 Jun;17(4):285-91. doi: 10.1016/0028-2243(84)90071-6. PMID: 6235140
Combination chemotherapy of advanced endometrial adenocarcinoma with adriamycin, cyclophosphamide, 5-fluorouracil, and medroxyprogesterone acetate.
Bruckner HW, Deppe G
Obstet Gynecol 1977 Jul;50(1 Suppl):10s-12s. PMID: 876531

Diagnosis

Advanced endometrial cancer following the insertion of the levonorgestrel-releasing intrauterine system in a 34-year-old woman: A case report.
Jiang J, Du H, Peng H
Contraception 2020 Dec;102(6):428-429. Epub 2020 Aug 27 doi: 10.1016/j.contraception.2020.08.010. PMID: 32860769
Splenic metastases in gynaecologic cancer: clinical considerations, US, and CT diagnostic results.
La Fianza A, Madonia L
Radiol Med 2003 Jul-Aug;106(1-2):36-43. PMID: 12951549

Therapy

Clinical and Biological Activity of Chemoimmunotherapy in Advanced Endometrial Adenocarcinoma: A Phase II Trial of the Big Ten Cancer Research Consortium.
Barber EL, Chen S, Pineda MJ, Robertson SE, Hill EK, Teoh D, Schilder J, O'Shea KL, Kocherginsky M, Zhang B, Matei D
Cancer Res Commun 2022 Oct;2(10):1293-1303. Epub 2022 Oct 28 doi: 10.1158/2767-9764.crc-22-0147. PMID: 36388466Free PMC Article
Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Therapeutic targeting of the TNF superfamily: a promising treatment for advanced endometrial adenocarcinoma.
Thangaraju S, Subramani E, Chakravarty B, Chaudhury K
Gynecol Oncol 2012 Nov;127(2):426-32. Epub 2012 Aug 7 doi: 10.1016/j.ygyno.2012.07.125. PMID: 22885470
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003915. doi: 10.1002/14651858.CD003915.pub3. PMID: 16235346
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Jul 20;(3):CD003915. doi: 10.1002/14651858.CD003915.pub2. PMID: 16034916

Prognosis

Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003915. doi: 10.1002/14651858.CD003915.pub3. PMID: 16235346
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Jul 20;(3):CD003915. doi: 10.1002/14651858.CD003915.pub2. PMID: 16034916
Tamoxifen and medroxyprogesterone therapy for advanced endometrial carcinoma.
Rendina GM, Donadio C, Fabri M, Mazzoni P, Nazzicone P
Eur J Obstet Gynecol Reprod Biol 1984 Jun;17(4):285-91. doi: 10.1016/0028-2243(84)90071-6. PMID: 6235140
Treatment of advanced endometrial adenocarcinoma with a combined cytotoxic therapy. Predictive value of cytosol estrogen and progestin receptor levels.
Kauppila A, Jänne O, Kujansuu E, Vihko R
Cancer 1980 Nov 15;46(10):2162-7. doi: 10.1002/1097-0142(19801115)46:10<2162::aid-cncr2820461010>3.0.co;2-v. PMID: 6253041
Doxorubicin-cyclophosphamide: effective chemotherapy for advanced endometrial adenocarcinoma.
Muggia FM, Chia G, Reed LJ, Romney SL
Am J Obstet Gynecol 1977 Jun 1;128(3):314-9. doi: 10.1016/0002-9378(77)90629-9. PMID: 860739

Clinical prediction guides

A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma.
Ang JE, Shah RN, Everard M, Keyzor C, Coombes I, Jenkins A, Thomas K, A'Hern R, Jones RL, Blake P, Gabra H, Hall G, Gore ME, Kaye SB
Ann Oncol 2009 Nov;20(11):1787-93. Epub 2009 Jun 19 doi: 10.1093/annonc/mdp193. PMID: 19542250
Paclitaxel/carboplatin versus cyclophosphamide/adriamycin/cisplatin as postoperative adjuvant chemotherapy for advanced endometrial adenocarcinoma.
Hidaka T, Nakamura T, Shima T, Yuki H, Saito S
J Obstet Gynaecol Res 2006 Jun;32(3):330-7. doi: 10.1111/j.1447-0756.2006.00405.x. PMID: 16764625
Splenic metastases in gynaecologic cancer: clinical considerations, US, and CT diagnostic results.
La Fianza A, Madonia L
Radiol Med 2003 Jul-Aug;106(1-2):36-43. PMID: 12951549
Epirubicin in advanced endometrial adenocarcinoma: a phase II study of the Grupo Ginecologico Español para el Tratamiento Oncologico (GGETO).
Calero F, Asins-Codoñer E, Jimeno J, Rodriguez Escudero F, Mendaña J, Iglesias J, Matía F, Armas A, Díaz-Castellanos R, Garzón J
Eur J Cancer 1991;27(7):864-6. doi: 10.1016/0277-5379(91)90135-z. PMID: 1834118
Treatment of advanced endometrial adenocarcinoma with a combined cytotoxic therapy. Predictive value of cytosol estrogen and progestin receptor levels.
Kauppila A, Jänne O, Kujansuu E, Vihko R
Cancer 1980 Nov 15;46(10):2162-7. doi: 10.1002/1097-0142(19801115)46:10<2162::aid-cncr2820461010>3.0.co;2-v. PMID: 6253041

Recent systematic reviews

Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003915. doi: 10.1002/14651858.CD003915.pub3. PMID: 16235346
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma.
Humber C, Tierney J, Symonds P, Collingwood M, Kirwan J, Williams C, Green J
Cochrane Database Syst Rev 2005 Jul 20;(3):CD003915. doi: 10.1002/14651858.CD003915.pub2. PMID: 16034916

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