Positive direct antiglobulin test

MedGen UID:: 1694410
•Concept ID:: C5139299
•: Laboratory or Test Result

HPO:	HP:0032366

Definition

A positive result of the direct antiglobulin test (DAT), a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPositive direct antiglobulin test

Phenotypic abnormality
- Abnormality of the immune system
  - Abnormality of immune system physiology
    - Autoimmunity
      - Autoimmune antibody positivity
        Anti-erythrocyte autoantibody positivity
        Positive direct antiglobulin test

Professional guidelines

PubMed

ABO hemolytic disease of the newborn: a need for clarity and consistency in diagnosis.

Watchko JF
J Perinatol 2023 Feb;43(2):242-247. Epub 2022 Nov 8 doi: 10.1038/s41372-022-01556-6. PMID: 36344813

Diagnosis and management of autoimmune hemolytic anemia in children.

Weli M, Ben Hlima A, Belhadj R, Maalej B, Elleuch A, Mekki N, Gargouri L, Kamoun T, Barbouche MR, Mahfoudh A
Transfus Clin Biol 2020 Apr;27(2):61-64. Epub 2020 Mar 30 doi: 10.1016/j.tracli.2020.03.003. PMID: 32280062

Defining autoimmune hemolytic anemia: a systematic review of the terminology used for diagnosis and treatment.

Hill QA, Hill A, Berentsen S
Blood Adv 2019 Jun 25;3(12):1897-1906. doi: 10.1182/bloodadvances.2019000036. PMID: 31235526 Free PMC Article

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