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Increased peripheral blast count

MedGen UID:
1705169
•Concept ID:
C5139302
•
Finding
Synonyms: Elevated blast count; Elevated circulating blasts; Increased peripheral myeloblast count
 
HPO: HP:0032372

Definition

An increased count in the peripheral blood of cells that are precursors to mature circulating blood cells such as neutrophiles, monocytes, lymphocutes, and erythrocytes. Blasts are not usually found in significant numbers in the peripheral blood circulation, but can be observed in hematopoietic neoplasms such as leukemia, severe infections, and as a result of certain medications. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased peripheral blast count

Professional guidelines

PubMed

Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management.
Parikh SA, Tefferi A
Am J Hematol 2013 Nov;88(11):967-74. doi: 10.1002/ajh.23574. PMID: 23963888
Signal transduction inhibitors in treatment of myelodysplastic syndromes.
Bachegowda L, Gligich O, Mantzaris I, Schinke C, Wyville D, Carrillo T, Braunschweig I, Steidl U, Verma A
J Hematol Oncol 2013 Jul 10;6:50. doi: 10.1186/1756-8722-6-50. PMID: 23841999Free PMC Article
ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse?
Thakar MS, Forman SJ
Hematology Am Soc Hematol Educ Program 2009:414-8. doi: 10.1182/asheducation-2009.1.414. PMID: 20008227

Recent clinical studies

Etiology

Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia.
Pospiech M, Tamizharasan M, Wei YC, Kumar AMS, Lou M, Milstein J, Alachkar H
Front Immunol 2023;14:1236514. Epub 2023 Oct 19 doi: 10.3389/fimmu.2023.1236514. PMID: 37928542Free PMC Article
Differences between leukemic arthritis and juvenile idiopathic arthritis.
Torres Jimenez AR, Solis Vallejo E, Cespedes Cruz AI, Ramirez Miramontes JV, Cortina Olvera GDC, Velazquez Cruz A, Sanchez Jara B
Pediatr Rheumatol Online J 2023 May 31;21(1):50. doi: 10.1186/s12969-023-00836-5. PMID: 37259088Free PMC Article
Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial.
Gonzalez-Lugo JD, Kambhampati S, Yacoub A, Donnellan WB, Berdeja J, Bhagat P, Fehn K, Remy C, Jasra S, Kazemi M, Pradhan K, Kim M, Mantzaris I, Sica RA, Shah N, Goldfinger M, Kornblum N, Gritsman K, Braunschweig I, Steidl U, Will B, Shastri A, Verma A
Clin Cancer Res 2023 Jan 4;29(1):60-66. doi: 10.1158/1078-0432.CCR-22-1457. PMID: 36255372
Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Mutations of myelodysplastic syndromes (MDS): An update.
Ganguly BB, Kadam NN
Mutat Res Rev Mutat Res 2016 Jul-Sep;769:47-62. Epub 2016 Jun 23 doi: 10.1016/j.mrrev.2016.04.009. PMID: 27543316

Diagnosis

Peripheral Blasts in a Patient Receiving Chemotherapy.
Kshattry S, Parker TL, Huntington SF
JAMA 2023 Oct 24;330(16):1581-1582. doi: 10.1001/jama.2023.17117. PMID: 37801303
Differences between leukemic arthritis and juvenile idiopathic arthritis.
Torres Jimenez AR, Solis Vallejo E, Cespedes Cruz AI, Ramirez Miramontes JV, Cortina Olvera GDC, Velazquez Cruz A, Sanchez Jara B
Pediatr Rheumatol Online J 2023 May 31;21(1):50. doi: 10.1186/s12969-023-00836-5. PMID: 37259088Free PMC Article
Leukocytosis.
Chabot-Richards DS, George TI
Int J Lab Hematol 2014 Jun;36(3):279-88. doi: 10.1111/ijlh.12212. PMID: 24750674
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165

Therapy

Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial.
Gonzalez-Lugo JD, Kambhampati S, Yacoub A, Donnellan WB, Berdeja J, Bhagat P, Fehn K, Remy C, Jasra S, Kazemi M, Pradhan K, Kim M, Mantzaris I, Sica RA, Shah N, Goldfinger M, Kornblum N, Gritsman K, Braunschweig I, Steidl U, Will B, Shastri A, Verma A
Clin Cancer Res 2023 Jan 4;29(1):60-66. doi: 10.1158/1078-0432.CCR-22-1457. PMID: 36255372
Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Treatment of Patients with Acute Myeloid Leukemia with the Targeted Alpha-Particle Nanogenerator Actinium-225-Lintuzumab.
Rosenblat TL, McDevitt MR, Carrasquillo JA, Pandit-Taskar N, Frattini MG, Maslak PG, Park JH, Douer D, Cicic D, Larson SM, Scheinberg DA, Jurcic JG
Clin Cancer Res 2022 May 13;28(10):2030-2037. doi: 10.1158/1078-0432.CCR-21-3712. PMID: 35247915Free PMC Article
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815
ASH evidence-based guidelines: is there a role for second allogeneic transplant after relapse?
Thakar MS, Forman SJ
Hematology Am Soc Hematol Educ Program 2009:414-8. doi: 10.1182/asheducation-2009.1.414. PMID: 20008227

Prognosis

Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial.
Gonzalez-Lugo JD, Kambhampati S, Yacoub A, Donnellan WB, Berdeja J, Bhagat P, Fehn K, Remy C, Jasra S, Kazemi M, Pradhan K, Kim M, Mantzaris I, Sica RA, Shah N, Goldfinger M, Kornblum N, Gritsman K, Braunschweig I, Steidl U, Will B, Shastri A, Verma A
Clin Cancer Res 2023 Jan 4;29(1):60-66. doi: 10.1158/1078-0432.CCR-22-1457. PMID: 36255372
Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Monocyte function in patients with myelodysplastic syndrome.
Pollyea DA, Hedin BR, O'Connor BP, Alper S
J Leukoc Biol 2018 Sep;104(3):641-647. Epub 2018 Apr 14 doi: 10.1002/JLB.5AB1017-419RR. PMID: 29656609Free PMC Article
Mutations of myelodysplastic syndromes (MDS): An update.
Ganguly BB, Kadam NN
Mutat Res Rev Mutat Res 2016 Jul-Sep;769:47-62. Epub 2016 Jun 23 doi: 10.1016/j.mrrev.2016.04.009. PMID: 27543316
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

Clinical prediction guides

Features of the TCR repertoire associate with patients' clinical and molecular characteristics in acute myeloid leukemia.
Pospiech M, Tamizharasan M, Wei YC, Kumar AMS, Lou M, Milstein J, Alachkar H
Front Immunol 2023;14:1236514. Epub 2023 Oct 19 doi: 10.3389/fimmu.2023.1236514. PMID: 37928542Free PMC Article
Abnormal immune function of B lymphocyte in peripheral blood of Parkinson's disease.
Zhang Z, Xie X, Cai Y, Liu P, Liu S, Chen R, Wang J, Wang Y, Zhao Y, Zhu Z, Zhang X, Wu J
Parkinsonism Relat Disord 2023 Nov;116:105890. Epub 2023 Oct 11 doi: 10.1016/j.parkreldis.2023.105890. PMID: 37839276
Allogeneic stem cell transplantation for patients with myelodysplastic syndromes.
Vittayawacharin P, Kongtim P, Ciurea SO
Am J Hematol 2023 Feb;98(2):322-337. Epub 2022 Oct 28 doi: 10.1002/ajh.26763. PMID: 36251347
Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome.
Watanabe K
Pediatr Int 2019 Mar;61(3):222-229. Epub 2019 Mar 4 doi: 10.1111/ped.13776. PMID: 30593694
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

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