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Abnormal CSF tryptophan concentration

MedGen UID:
1705982
•Concept ID:
C5139603
•
Finding
Synonym: Abnormal tryptophan levels in cerebrospinal fluid
 
HPO: HP:0500218

Definition

Any deviation from the normal concentration of tryptophan in the cerebrospinal fluid. [from HPO]

Recent clinical studies

Etiology

Stable isotope dilution ultra-high performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan-related neuroactive substances in human serum and cerebrospinal fluid.
Hényková E, Vránová HP, Amakorová P, Pospíšil T, Žukauskaitė A, Vlčková M, Urbánek L, Novák O, Mareš J, Kaňovský P, Strnad M
J Chromatogr A 2016 Mar 11;1437:145-157. Epub 2016 Feb 6 doi: 10.1016/j.chroma.2016.02.009. PMID: 26879452
Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up.
Kusmierska K, Jansen EE, Jakobs C, Szymanska K, Malunowicz E, Meilei D, Thony B, Blau N, Tryfon J, Rokicki D, Pronicka E, Sykut-Cegielska J
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S5-10. Epub 2009 Jan 7 doi: 10.1007/s10545-008-1009-4. PMID: 19130291
Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling.
Geracioti TD Jr, Loosen PT, Ekhator NN, Schmidt D, Chambliss B, Baker DG, Kasckow JW, Richtand NM, Keck PE Jr, Ebert MH
Depress Anxiety 1997;6(3):89-94. PMID: 9442982
Concentrations of corticotropin-releasing hormone, norepinephrine, MHPG, 5-hydroxyindoleacetic acid, and tryptophan in the cerebrospinal fluid of alcoholic patients: serial sampling studies.
Geracioti TD Jr, Loosen PT, Ebert MH, Ekhator NN, Burns D, Nicholson WE, Orth DN
Neuroendocrinology 1994 Dec;60(6):635-42. doi: 10.1159/000126807. PMID: 7535389
Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan.
López-Ibor JJ Jr, Saiz-Ruiz J, Pérez de los Cobos JC
Neuropsychobiology 1985;14(2):67-74. doi: 10.1159/000118207. PMID: 2418384

Diagnosis

Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up.
Kusmierska K, Jansen EE, Jakobs C, Szymanska K, Malunowicz E, Meilei D, Thony B, Blau N, Tryfon J, Rokicki D, Pronicka E, Sykut-Cegielska J
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S5-10. Epub 2009 Jan 7 doi: 10.1007/s10545-008-1009-4. PMID: 19130291
High performance liquid chromatography as a tool in the definition of abnormalities in monoamine and tryptophan metabolites in cerebrospinal fluid from patients with neurological disorders.
Baig S, Halawa I, Qureshi GA
Biomed Chromatogr 1991 May;5(3):108-12. doi: 10.1002/bmc.1130050304. PMID: 1863804
Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid.
Volicer L, Langlais PJ, Matson WR, Mark KA, Gamache PH
Arch Neurol 1985 Dec;42(12):1158-61. doi: 10.1001/archneur.1985.04060110040013. PMID: 2415092
Cerebrospinal fluid amine metabolites in delirium tremens.
Banki CM, Molnar G
Psychiatr Clin (Basel) 1981;14(3):167-77. doi: 10.1159/000283913. PMID: 6173895
Study of disturbed tryptophan metabolism in depressive illness.
Curzon G
Ann Biol Clin (Paris) 1979;37(1):27-33. PMID: 443610

Therapy

Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up.
Kusmierska K, Jansen EE, Jakobs C, Szymanska K, Malunowicz E, Meilei D, Thony B, Blau N, Tryfon J, Rokicki D, Pronicka E, Sykut-Cegielska J
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S5-10. Epub 2009 Jan 7 doi: 10.1007/s10545-008-1009-4. PMID: 19130291
Role of serotonin in obsessive-compulsive disorder.
Baumgarten HG, Grozdanovic Z
Br J Psychiatry Suppl 1998;(35):13-20. PMID: 9829022
Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan.
Pranzatelli MR, Tate E, Huang Y, Haas RH, Bodensteiner J, Ashwal S, Franz D
Epilepsia 1995 Aug;36(8):783-91. doi: 10.1111/j.1528-1157.1995.tb01615.x. PMID: 7543407
Tetrahydrobiopterin in dystonia: identification of abnormal metabolism and therapeutic trials.
LeWitt PA, Miller LP, Levine RA, Lovenberg W, Newman RP, Papavasiliou A, Rayes A, Eldridge R, Burns RS
Neurology 1986 Jun;36(6):760-4. doi: 10.1212/wnl.36.6.760. PMID: 3703282
Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan.
López-Ibor JJ Jr, Saiz-Ruiz J, Pérez de los Cobos JC
Neuropsychobiology 1985;14(2):67-74. doi: 10.1159/000118207. PMID: 2418384

Prognosis

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders.
Skorobogatov K, De Picker L, Verkerk R, Coppens V, Leboyer M, Müller N, Morrens M
Front Immunol 2021;12:716980. Epub 2021 Sep 23 doi: 10.3389/fimmu.2021.716980. PMID: 34630391Free PMC Article
Elevated cerebrospinal fluid kynurenic acid levels in patients with tick-borne encephalitis.
Holtze M, Mickiené A, Atlas A, Lindquist L, Schwieler L
J Intern Med 2012 Oct;272(4):394-401. Epub 2012 Apr 19 doi: 10.1111/j.1365-2796.2012.02539.x. PMID: 22443218
Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up.
Kusmierska K, Jansen EE, Jakobs C, Szymanska K, Malunowicz E, Meilei D, Thony B, Blau N, Tryfon J, Rokicki D, Pronicka E, Sykut-Cegielska J
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S5-10. Epub 2009 Jan 7 doi: 10.1007/s10545-008-1009-4. PMID: 19130291

Clinical prediction guides

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders.
Skorobogatov K, De Picker L, Verkerk R, Coppens V, Leboyer M, Müller N, Morrens M
Front Immunol 2021;12:716980. Epub 2021 Sep 23 doi: 10.3389/fimmu.2021.716980. PMID: 34630391Free PMC Article
Sepiapterin reductase deficiency in a 2-year-old girl with incomplete response to treatment during short-term follow-up.
Kusmierska K, Jansen EE, Jakobs C, Szymanska K, Malunowicz E, Meilei D, Thony B, Blau N, Tryfon J, Rokicki D, Pronicka E, Sykut-Cegielska J
J Inherit Metab Dis 2009 Dec;32 Suppl 1:S5-10. Epub 2009 Jan 7 doi: 10.1007/s10545-008-1009-4. PMID: 19130291
Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling.
Geracioti TD Jr, Loosen PT, Ekhator NN, Schmidt D, Chambliss B, Baker DG, Kasckow JW, Richtand NM, Keck PE Jr, Ebert MH
Depress Anxiety 1997;6(3):89-94. PMID: 9442982
Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan.
Pranzatelli MR, Tate E, Huang Y, Haas RH, Bodensteiner J, Ashwal S, Franz D
Epilepsia 1995 Aug;36(8):783-91. doi: 10.1111/j.1528-1157.1995.tb01615.x. PMID: 7543407
Tetrahydrobiopterin in dystonia: identification of abnormal metabolism and therapeutic trials.
LeWitt PA, Miller LP, Levine RA, Lovenberg W, Newman RP, Papavasiliou A, Rayes A, Eldridge R, Burns RS
Neurology 1986 Jun;36(6):760-4. doi: 10.1212/wnl.36.6.760. PMID: 3703282

Recent systematic reviews

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders.
Skorobogatov K, De Picker L, Verkerk R, Coppens V, Leboyer M, Müller N, Morrens M
Front Immunol 2021;12:716980. Epub 2021 Sep 23 doi: 10.3389/fimmu.2021.716980. PMID: 34630391Free PMC Article

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