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Skin Myoepithelioma

MedGen UID:
1708368
•Concept ID:
C5238499
•
Neoplastic Process
Synonym: Cutaneous Myoepithelioma

Definition

A benign skin neoplasm composed exclusively of myoepithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Myoepithelioma

Professional guidelines

PubMed

Mesenchymal tumours with melanocytic expression: a potential pitfall in the differential diagnosis of malignant melanoma.
Saleh JS, Whittington CP, Bresler SC, Patel RM
Pathology 2023 Mar;55(2):258-268. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.340. PMID: 36639332

Recent clinical studies

Etiology

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements.
Suurmeijer AJH, Dickson BC, Swanson D, Zhang L, Sung YS, Fletcher CD, Antonescu CR
Genes Chromosomes Cancer 2020 Jun;59(6):348-356. Epub 2020 Feb 7 doi: 10.1002/gcc.22835. PMID: 31994243Free PMC Article
Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features.
Jo VY, Fletcher CD
Head Neck Pathol 2015 Mar;9(1):32-8. Epub 2015 Mar 25 doi: 10.1007/s12105-015-0618-0. PMID: 25804378Free PMC Article
Primary myoepithelial carcinoma of palate.
Ren J, Liu Z, Liu X, Li Y, Zhang X, Li Z, Yang Y, Yang Y, Chen Y, Jiang S
World J Surg Oncol 2011 Sep 14;9:104. doi: 10.1186/1477-7819-9-104. PMID: 21917131Free PMC Article
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Diagnosis

New fusion sarcomas: histopathology and clinical significance of selected entities.
Miettinen M, Felisiak-Golabek A, Luiña Contreras A, Glod J, Kaplan RN, Killian JK, Lasota J
Hum Pathol 2019 Apr;86:57-65. Epub 2019 Jan 8 doi: 10.1016/j.humpath.2018.12.006. PMID: 30633925Free PMC Article
Myoepithelial Tumors: An Update.
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor.
Seethala RR
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S77-84. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0461-0. PMID: 23821213Free PMC Article
New or unusual dermatopathology tumors: a review.
Lewin MR, Montgomery EA, Barrett TL
J Cutan Pathol 2011 Sep;38(9):689-96. doi: 10.1111/j.1600-0560.2011.01767.x. PMID: 21790713
Metastatic parachordoma.
Guedes A, Barreto BG, Barreto LG, de Oliveira Araújo IB, Queiroz AC, Athanazio DA, Athanazio PR
J Cutan Pathol 2009 Feb;36(2):270-3. doi: 10.1111/j.1600-0560.2008.01032.x. PMID: 19208078

Therapy

Association between skin flap thickness and Frey's syndrome in parotid surgery.
Durgut O, Basut O, Demir UL, Ozmen OA, Kasapoglu F, Coskun H
Head Neck 2013 Dec;35(12):1781-6. Epub 2013 Mar 8 doi: 10.1002/hed.23233. PMID: 23471856
Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor.
Fisher C
Semin Diagn Pathol 2013 Feb;30(1):73-84. doi: 10.1053/j.semdp.2012.01.006. PMID: 23327731
A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart.
Bahrami A, Dalton JD, Krane JF, Fletcher CD
Genes Chromosomes Cancer 2012 Feb;51(2):140-8. Epub 2011 Oct 28 doi: 10.1002/gcc.20938. PMID: 22038920Free PMC Article
Malignant myoepithelioma of the breast.
Terada T
Pathol Int 2011 Feb;61(2):99-103. Epub 2010 Dec 13 doi: 10.1111/j.1440-1827.2010.02638.x. PMID: 21255187
Clear cell myoepithelial neoplasm of the breast.
Cartagena N Jr, Cabello-Inchausti B, Willis I, Poppiti R Jr
Hum Pathol 1988 Oct;19(10):1239-43. doi: 10.1016/s0046-8177(88)80159-x. PMID: 2844648

Prognosis

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
New fusion sarcomas: histopathology and clinical significance of selected entities.
Miettinen M, Felisiak-Golabek A, Luiña Contreras A, Glod J, Kaplan RN, Killian JK, Lasota J
Hum Pathol 2019 Apr;86:57-65. Epub 2019 Jan 8 doi: 10.1016/j.humpath.2018.12.006. PMID: 30633925Free PMC Article
Myoepithelial Tumors: An Update.
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Dermatology clinics: what's new in dermatopathology: news in nonmelanocytic neoplasia.
Sidhu HK, Patel RV, Goldenberg G
Dermatol Clin 2012 Oct;30(4):623-41, vi. Epub 2012 Aug 13 doi: 10.1016/j.det.2012.06.009. PMID: 23021050
Histopathology of malignant salivary gland tumours.
Seifert G
Eur J Cancer B Oral Oncol 1992 Jul;28B(1):49-56. doi: 10.1016/0964-1955(92)90013-q. PMID: 1330147

Clinical prediction guides

SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors.
Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
A case of cutaneous syncytial myoepithelioma with extensive adipocytic metaplasia: Usefulness of EWSR1-PBX3 gene fusion analysis.
Shimada K, Ansai O, Katsumi T, Deguchi T, Hayashi R, Yuki A, Nakamura M, Umezu H, Fukumoto T, Ansai SI, Abe R
J Cutan Pathol 2022 Apr;49(4):412-417. Epub 2022 Jan 4 doi: 10.1111/cup.14179. PMID: 34854109
Cutaneous adenomyoepithelioma with histopathological heterogeneity: A case report.
Shiomi T, Matsuno T, Nishimura H, Moriya T
Pathol Int 2021 Nov;71(11):783-788. Epub 2021 Sep 2 doi: 10.1111/pin.13157. PMID: 34473865
A case of cutaneous myoepithelial carcinoma.
Tanahashi J, Kashima K, Daa T, Kondo Y, Kuratomi E, Yokoyama S
J Cutan Pathol 2007 Aug;34(8):648-53. doi: 10.1111/j.1600-0560.2006.00676.x. PMID: 17640237

Recent systematic reviews

Impact of adjuvant therapy on survival in patients with myoepithelial carcinoma: A systematic review and individual patient data analysis of 691 patients.
Giridhar P, Gupta P, Mallick S, Upadhyay AD, Rath GK
Radiother Oncol 2019 Nov;140:125-130. Epub 2019 Jul 2 doi: 10.1016/j.radonc.2019.06.017. PMID: 31276988

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