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Benign epithelial skin neoplasm

MedGen UID:
83395
•Concept ID:
C0345981
•
Neoplastic Process
Synonyms: Benign epithelial neoplasm of skin; Benign Epithelial Skin Neoplasm; benign epithelial skin neoplasm; Benign Epithelial Skin Tumor; benign epithelial skin tumor; benign epithelial skin tumour; Benign Skin Epithelium Neoplasm; benign skin epithelium neoplasm; Benign Skin Epithelium Tumor; benign skin epithelium tumor; benign skin epithelium tumour; Benign tumor of surface epithelium; epithelial skin neoplasm, benign
SNOMED CT: Benign epithelial neoplasm of skin (254658001); Benign tumor of surface epithelium (254658001)
 
Monarch Initiative: MONDO:0024666

Definition

An epithelial neoplasm that arises from the skin and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Clinical and histopathological profile of primary caruncular lesions.
Alam MS, Pal SS, Krishnakumar S
Indian J Ophthalmol 2022 Jun;70(6):1975-1981. doi: 10.4103/ijo.IJO_2724_21. PMID: 35647965Free PMC Article
Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094759. PMID: 33946233Free PMC Article
On the differential diagnosis of clear cell tumours of the head and neck.
Eversole LR
Eur J Cancer B Oral Oncol 1993 Jul;29B(3):173-9. doi: 10.1016/0964-1955(93)90019-b. PMID: 8298420

Recent clinical studies

Etiology

Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge.
Pešut E, Đukić A, Lulić L, Skelin J, Šimić I, Milutin Gašperov N, Tomaić V, Sabol I, Grce M
Viruses 2021 Nov 6;13(11) doi: 10.3390/v13112234. PMID: 34835040Free PMC Article
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
The low-risk papillomaviruses.
Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475
Pathology of eyelid tumors.
Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927Free PMC Article
Cutaneous lymphoepithelial neoplasms.
Okamura JM, Barr RJ
Adv Dermatol 1997;12:277-94; discussion 295. PMID: 8973744

Diagnosis

Follicular mucinosis: a review.
Khalil J, Kurban M, Abbas O
Int J Dermatol 2021 Feb;60(2):159-165. Epub 2020 Sep 2 doi: 10.1111/ijd.15165. PMID: 32880923
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Therapy

Novel approaches for managing aged skin and nonmelanoma skin cancer.
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451
Genital human papillomavirus infections.
Kaliterna V, Barisic Z
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1587-1611. doi: 10.2741/4662. PMID: 29293452
Aluminium and the human breast.
Darbre PD
Morphologie 2016 Jun;100(329):65-74. Epub 2016 Mar 17 doi: 10.1016/j.morpho.2016.02.001. PMID: 26997127
Papillomaviruses and interferon.
Androphy EJ
Ciba Found Symp 1986;120:221-34. doi: 10.1002/9780470513309.ch15. PMID: 2424679
Breast adenomas.
Hertel BF, Zaloudek C, Kempson RL
Cancer 1976 Jun;37(6):2891-905. doi: 10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p. PMID: 949710

Prognosis

Clinical relevance and implications of HPV-induced neoplasia in different anatomical locations.
Prigge ES, von Knebel Doeberitz M, Reuschenbach M
Mutat Res Rev Mutat Res 2017 Apr-Jun;772:51-66. Epub 2016 Jun 22 doi: 10.1016/j.mrrev.2016.06.005. PMID: 28528690
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807
Acral lentiginous nevus.
Han KH, Cho KH
J Dermatol 1998 Jan;25(1):23-7. doi: 10.1111/j.1346-8138.1998.tb02340.x. PMID: 9519605

Clinical prediction guides

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features.
Mehta A, Davey J, Gharpuray-Pandit D, Plaza JA, Billings SD, Balogh P, Tchrakian N, Selvan S, Wiedemeyer K, Hornick JL, Brenn T
Am J Surg Pathol 2022 Sep 1;46(9):1241-1249. Epub 2022 Mar 31 doi: 10.1097/PAS.0000000000001896. PMID: 35354162
Clear cell lesions in pathology: Histomorphologic approach to diagnosis.
Kar A, Pattnaik K, Kar T, Biswal P, Mishra C, Guru L
Indian J Pathol Microbiol 2020 Apr-Jun;63(2):177-187. doi: 10.4103/IJPM.IJPM_791_19. PMID: 32317512
Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Recent systematic reviews

A systematic review of Pilomatrix carcinoma arising from the previous scar site of Pilomatrixoma.
Panda SK, Sahoo PK, Agarwala SK, Houghton TT, Sankar KV, Mohanty P
J Cancer Res Ther 2023 Jul-Sep;19(5):1098-1102. doi: 10.4103/jcrt.jcrt_720_21. PMID: 37787269
Novel approaches for managing aged skin and nonmelanoma skin cancer.
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451

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