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Locally Advanced Hypopharyngeal Squamous Cell Carcinoma

MedGen UID:
1713861
•Concept ID:
C5237383
•
Neoplastic Process

Definition

Hypopharyngeal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Hypopharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy.
Wang D, Yu S, Zhai L, Xu J, Li B
BMC Cancer 2020 Apr 6;20(1):283. doi: 10.1186/s12885-020-06793-6. PMID: 32252691Free PMC Article
Contemporary therapeutic management of locally advanced hypopharyngeal cancer: oncologic and functional outcomes - a report on 100 cases.
Vandersteen C, Benezery K, Chamorey E, Ettaiche M, Dassonville O, Poissonnet G, Riss JC, Pierre CS, Hannoun-Lévi JM, Chand ME, Leyssale A, Peyrade F, Sudaka A, Haudebourg J, Demard F, Santini J, Bozec A
Acta Otolaryngol 2015 Feb;135(2):193-200. doi: 10.3109/00016489.2014.968673. PMID: 25578129

Recent clinical studies

Etiology

Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer.
Nishimura A, Yokota T, Hamauchi S, Onozawa Y, Notsu A, Sato F, Kawakami T, Ogawa H, Onoe T, Mukaigawa T
BMC Cancer 2022 Oct 27;22(1):1101. doi: 10.1186/s12885-022-10172-8. PMID: 36303119Free PMC Article
Induction chemotherapy of modified docetaxel, cisplatin, 5-fluorouracil for laryngeal preservation in locally advanced hypopharyngeal squamous cell carcinoma.
Li R, Ye L, Zhu Y, Ding H, Wang S, Ying H, Wu C, Zhou L, Wang X, Tian S
Head Neck 2022 Sep;44(9):2018-2029. doi: 10.1002/hed.27119. PMID: 35915867
Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy.
Wang D, Yu S, Zhai L, Xu J, Li B
BMC Cancer 2020 Apr 6;20(1):283. doi: 10.1186/s12885-020-06793-6. PMID: 32252691Free PMC Article
Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.
Juloori A, Koyfman SA, Geiger JL, Joshi NP, Woody NM, Burkey BB, Scharpf J, Lamarre EL, Prendes B, Adelstein DJ, Greskovich JF, Keller L
Anticancer Res 2018 Jun;38(6):3543-3549. doi: 10.21873/anticanres.12626. PMID: 29848708

Diagnosis

Developing a predictive nomogram and web-based survival calculator for locally advanced hypopharyngeal cancer: A propensity score-adjusted, population-based study.
Chen S, He S, Wang D, Liu Y, Shao S, Tang L, Li C, Shi Q, Liu J, Wang F, Zhang S
Biomol Biomed 2023 Sep 4;23(5):902-913. doi: 10.17305/bb.2023.8978. PMID: 37096424Free PMC Article
Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer.
Nishimura A, Yokota T, Hamauchi S, Onozawa Y, Notsu A, Sato F, Kawakami T, Ogawa H, Onoe T, Mukaigawa T
BMC Cancer 2022 Oct 27;22(1):1101. doi: 10.1186/s12885-022-10172-8. PMID: 36303119Free PMC Article
Pretherapy platelet-to-lymphocyte ratio as a prognostic parameter for locally advanced hypopharyngeal cancer patients treated with radiotherapy combined with chemotherapy.
Wan M, Zhao D, Liu W, Huang Z, Xu X, Zheng B, Xiao S, Sun Y, Wang W
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5859-5868. Epub 2022 Jul 18 doi: 10.1007/s00405-022-07495-4. PMID: 35849189
Glasgow prognostic score and neutrophil-lymphocyte ratio are good prognostic indicators after radical neck dissection for advanced squamous cell carcinoma in the hypopharynx.
Ikeguchi M
Langenbecks Arch Surg 2016 Sep;401(6):861-6. Epub 2016 May 28 doi: 10.1007/s00423-016-1453-9. PMID: 27236289
Different clinical outcomes between locally advanced hypopharyngeal and oropharyngeal cancer treated with definitive concurrent chemoradiotherapy: implication for subgroup selection for induction chemotherapy.
Lim SH, Lee SJ, Ahn MJ, Park K, Sun JM
Jpn J Clin Oncol 2016 Jan;46(1):40-5. Epub 2015 Nov 10 doi: 10.1093/jjco/hyv163. PMID: 26561556

Therapy

Developing a predictive nomogram and web-based survival calculator for locally advanced hypopharyngeal cancer: A propensity score-adjusted, population-based study.
Chen S, He S, Wang D, Liu Y, Shao S, Tang L, Li C, Shi Q, Liu J, Wang F, Zhang S
Biomol Biomed 2023 Sep 4;23(5):902-913. doi: 10.17305/bb.2023.8978. PMID: 37096424Free PMC Article
Induction chemotherapy of modified docetaxel, cisplatin, 5-fluorouracil for laryngeal preservation in locally advanced hypopharyngeal squamous cell carcinoma.
Li R, Ye L, Zhu Y, Ding H, Wang S, Ying H, Wu C, Zhou L, Wang X, Tian S
Head Neck 2022 Sep;44(9):2018-2029. doi: 10.1002/hed.27119. PMID: 35915867
Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy.
Wang D, Yu S, Zhai L, Xu J, Li B
BMC Cancer 2020 Apr 6;20(1):283. doi: 10.1186/s12885-020-06793-6. PMID: 32252691Free PMC Article
Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.
Juloori A, Koyfman SA, Geiger JL, Joshi NP, Woody NM, Burkey BB, Scharpf J, Lamarre EL, Prendes B, Adelstein DJ, Greskovich JF, Keller L
Anticancer Res 2018 Jun;38(6):3543-3549. doi: 10.21873/anticanres.12626. PMID: 29848708

Prognosis

Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer.
Nishimura A, Yokota T, Hamauchi S, Onozawa Y, Notsu A, Sato F, Kawakami T, Ogawa H, Onoe T, Mukaigawa T
BMC Cancer 2022 Oct 27;22(1):1101. doi: 10.1186/s12885-022-10172-8. PMID: 36303119Free PMC Article
Pretherapy platelet-to-lymphocyte ratio as a prognostic parameter for locally advanced hypopharyngeal cancer patients treated with radiotherapy combined with chemotherapy.
Wan M, Zhao D, Liu W, Huang Z, Xu X, Zheng B, Xiao S, Sun Y, Wang W
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5859-5868. Epub 2022 Jul 18 doi: 10.1007/s00405-022-07495-4. PMID: 35849189
Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy.
Wang D, Yu S, Zhai L, Xu J, Li B
BMC Cancer 2020 Apr 6;20(1):283. doi: 10.1186/s12885-020-06793-6. PMID: 32252691Free PMC Article
Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.
Juloori A, Koyfman SA, Geiger JL, Joshi NP, Woody NM, Burkey BB, Scharpf J, Lamarre EL, Prendes B, Adelstein DJ, Greskovich JF, Keller L
Anticancer Res 2018 Jun;38(6):3543-3549. doi: 10.21873/anticanres.12626. PMID: 29848708

Clinical prediction guides

Developing a predictive nomogram and web-based survival calculator for locally advanced hypopharyngeal cancer: A propensity score-adjusted, population-based study.
Chen S, He S, Wang D, Liu Y, Shao S, Tang L, Li C, Shi Q, Liu J, Wang F, Zhang S
Biomol Biomed 2023 Sep 4;23(5):902-913. doi: 10.17305/bb.2023.8978. PMID: 37096424Free PMC Article
Pretherapy platelet-to-lymphocyte ratio as a prognostic parameter for locally advanced hypopharyngeal cancer patients treated with radiotherapy combined with chemotherapy.
Wan M, Zhao D, Liu W, Huang Z, Xu X, Zheng B, Xiao S, Sun Y, Wang W
Eur Arch Otorhinolaryngol 2022 Dec;279(12):5859-5868. Epub 2022 Jul 18 doi: 10.1007/s00405-022-07495-4. PMID: 35849189
Nomograms predicting prognosis for locally advanced hypopharyngeal squamous cell carcinoma.
Yang H, Zeng M, Cao S, Jin L
Eur Arch Otorhinolaryngol 2022 Jun;279(6):3041-3052. Epub 2021 Oct 14 doi: 10.1007/s00405-021-07109-5. PMID: 34648051
Glasgow prognostic score and neutrophil-lymphocyte ratio are good prognostic indicators after radical neck dissection for advanced squamous cell carcinoma in the hypopharynx.
Ikeguchi M
Langenbecks Arch Surg 2016 Sep;401(6):861-6. Epub 2016 May 28 doi: 10.1007/s00423-016-1453-9. PMID: 27236289
Contemporary therapeutic management of locally advanced hypopharyngeal cancer: oncologic and functional outcomes - a report on 100 cases.
Vandersteen C, Benezery K, Chamorey E, Ettaiche M, Dassonville O, Poissonnet G, Riss JC, Pierre CS, Hannoun-Lévi JM, Chand ME, Leyssale A, Peyrade F, Sudaka A, Haudebourg J, Demard F, Santini J, Bozec A
Acta Otolaryngol 2015 Feb;135(2):193-200. doi: 10.3109/00016489.2014.968673. PMID: 25578129

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