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Computed tomographic halo sign

MedGen UID:
1718487
•Concept ID:
C5397963
•
Finding
Synonym: CT halo sign
 
HPO: HP:0032971

Definition

CT finding of ground-glass opacity surrounding a nodule or mass. It was first described as a sign of hemorrhage around foci of invasive aspergillosis. The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComputed tomographic halo sign

Professional guidelines

PubMed

Comparative cost-effectiveness of voriconazole and amphotericin B in treatment of invasive pulmonary aspergillosis.
Greene RE, Mauskopf J, Roberts CS, Zyczynski T, Schlamm HT
Am J Health Syst Pharm 2007 Dec 15;64(24):2561-8. doi: 10.2146/ajhp060584. PMID: 18056944

Recent clinical studies

Etiology

COVID-19 Infection in Octagenarian Patients: Imaging Aspects and Clinical Correlations.
Takahashi AME, do Nascimento ABB, Barros AS, Gaspar MB, Silva MO, Machado FP
Gerontology 2022;68(3):261-271. Epub 2021 Aug 5 doi: 10.1159/000516166. PMID: 34515129Free PMC Article
Chest computed tomography findings in different phases of SARS-CoV-2 infection.
Soriano Aguadero I, Ezponda Casajús A, Mendoza Ferradas F, Igual Rouilleault A, Paternain Nuin A, Pueyo Villoslada J, Bastarrika G
Radiologia (Engl Ed) 2021 May-Jun;63(3):218-227. Epub 2021 Feb 27 doi: 10.1016/j.rx.2021.02.004. PMID: 33743999Free PMC Article
Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital.
Peng L, Liu KY, Xue F, Miao YF, Tu PA, Zhou C
Arch Iran Med 2020 Apr 1;23(4):272-276. doi: 10.34172/aim.2020.10. PMID: 32271602
Comparison of computed tomographic findings in pulmonary mucormycosis and invasive pulmonary aspergillosis.
Jung J, Kim MY, Lee HJ, Park YS, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH
Clin Microbiol Infect 2015 Jul;21(7):684.e11-8. Epub 2015 Apr 13 doi: 10.1016/j.cmi.2015.03.019. PMID: 25882362
Reversed halo sign in acute pulmonary embolism and infarction.
Casullo J, Semionov A
Acta Radiol 2013 Jun;54(5):505-10. Epub 2013 Apr 30 doi: 10.1177/0284185113475797. PMID: 23395814

Diagnosis

Pathology-radiology correlation of common and uncommon computed tomographic patterns of organizing pneumonia.
Torrealba JR, Fisher S, Kanne JP, Butt YM, Glazer C, Kershaw C, Burguete D, Gokaslan T, Batra K
Hum Pathol 2018 Jan;71:30-40. Epub 2017 Nov 7 doi: 10.1016/j.humpath.2017.10.028. PMID: 29122655
Comparison of computed tomographic findings in pulmonary mucormycosis and invasive pulmonary aspergillosis.
Jung J, Kim MY, Lee HJ, Park YS, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH
Clin Microbiol Infect 2015 Jul;21(7):684.e11-8. Epub 2015 Apr 13 doi: 10.1016/j.cmi.2015.03.019. PMID: 25882362
Reversed halo sign in acute pulmonary embolism and infarction.
Casullo J, Semionov A
Acta Radiol 2013 Jun;54(5):505-10. Epub 2013 Apr 30 doi: 10.1177/0284185113475797. PMID: 23395814
Imaging studies for diagnosing invasive fungal pneumonia in immunocompromised patients.
Marom EM, Kontoyiannis DP
Curr Opin Infect Dis 2011 Aug;24(4):309-14. doi: 10.1097/QCO.0b013e328348b2e1. PMID: 21673574
CT signs and patterns of lung disease.
Collins J
Radiol Clin North Am 2001 Nov;39(6):1115-35. doi: 10.1016/s0033-8389(05)70334-1. PMID: 11699664

Therapy

Cocaine-induced pulmonary changes: HRCT findings.
Almeida RR, Zanetti G, Souza AS Jr, Souza LS, Silva JL, Escuissato DL, Irion KL, Mançano AD, Nobre LF, Hochhegger B, Marchiori E
J Bras Pneumol 2015 Jul-Aug;41(4):323-30. doi: 10.1590/S1806-37132015000000025. PMID: 26398752Free PMC Article
A Novel Radiographic Sign and a New Classifying System in Mastoiditis-Related Epidural Abscess.
Horowitz G, Fishman G, Brenner A, Abu-Ghanem S, Derowe A, Cavel O, Fliss DM, Segev Y
Otol Neurotol 2015 Sep;36(8):1378-82. doi: 10.1097/MAO.0000000000000810. PMID: 26275182
High-resolution computed tomographic findings of Aspergillus infection in lung transplant patients.
Gazzoni FF, Hochhegger B, Severo LC, Marchiori E, Pasqualotto A, Sartori AP, Schio S, Camargo J
Eur J Radiol 2014 Jan;83(1):79-83. Epub 2013 May 8 doi: 10.1016/j.ejrad.2013.03.026. PMID: 23664649
Comparative cost-effectiveness of voriconazole and amphotericin B in treatment of invasive pulmonary aspergillosis.
Greene RE, Mauskopf J, Roberts CS, Zyczynski T, Schlamm HT
Am J Health Syst Pharm 2007 Dec 15;64(24):2561-8. doi: 10.2146/ajhp060584. PMID: 18056944
CT signs and patterns of lung disease.
Collins J
Radiol Clin North Am 2001 Nov;39(6):1115-35. doi: 10.1016/s0033-8389(05)70334-1. PMID: 11699664

Prognosis

Chest computed tomography findings in different phases of SARS-CoV-2 infection.
Soriano Aguadero I, Ezponda Casajús A, Mendoza Ferradas F, Igual Rouilleault A, Paternain Nuin A, Pueyo Villoslada J, Bastarrika G
Radiologia (Engl Ed) 2021 May-Jun;63(3):218-227. Epub 2021 Feb 27 doi: 10.1016/j.rx.2021.02.004. PMID: 33743999Free PMC Article
Radiologic findings of primary pulmonary angiosarcoma: A case report.
Ma J, Zhang W, Huang Y, Wang L, Wang J, Yuan L, Zhang J
Medicine (Baltimore) 2018 Jun;97(25):e11105. doi: 10.1097/MD.0000000000011105. PMID: 29924006Free PMC Article
The reversed halo sign: pathognomonic pattern of pulmonary mucormycosis in leukemic patients with neutropenia?
Legouge C, Caillot D, Chrétien ML, Lafon I, Ferrant E, Audia S, Pagès PB, Roques M, Estivalet L, Martin L, Maitre T, Bastie JN, Dalle F
Clin Infect Dis 2014 Mar;58(5):672-8. Epub 2013 Dec 18 doi: 10.1093/cid/cit929. PMID: 24352351
Kidney neoplasms: renal halo sign after percutaneous radiofrequency ablation--incidence and clinical importance in 101 consecutive patients.
Schirmang TC, Mayo-Smith WW, Dupuy DE, Beland MD, Grand DJ
Radiology 2009 Oct;253(1):263-9. Epub 2009 Jul 31 doi: 10.1148/radiol.2531082257. PMID: 19703853
Comparative cost-effectiveness of voriconazole and amphotericin B in treatment of invasive pulmonary aspergillosis.
Greene RE, Mauskopf J, Roberts CS, Zyczynski T, Schlamm HT
Am J Health Syst Pharm 2007 Dec 15;64(24):2561-8. doi: 10.2146/ajhp060584. PMID: 18056944

Clinical prediction guides

COVID-19 Infection in Octagenarian Patients: Imaging Aspects and Clinical Correlations.
Takahashi AME, do Nascimento ABB, Barros AS, Gaspar MB, Silva MO, Machado FP
Gerontology 2022;68(3):261-271. Epub 2021 Aug 5 doi: 10.1159/000516166. PMID: 34515129Free PMC Article
Chest computed tomography findings in different phases of SARS-CoV-2 infection.
Soriano Aguadero I, Ezponda Casajús A, Mendoza Ferradas F, Igual Rouilleault A, Paternain Nuin A, Pueyo Villoslada J, Bastarrika G
Radiologia (Engl Ed) 2021 May-Jun;63(3):218-227. Epub 2021 Feb 27 doi: 10.1016/j.rx.2021.02.004. PMID: 33743999Free PMC Article
Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital.
Peng L, Liu KY, Xue F, Miao YF, Tu PA, Zhou C
Arch Iran Med 2020 Apr 1;23(4):272-276. doi: 10.34172/aim.2020.10. PMID: 32271602
Reversed halo sign in acute pulmonary embolism and infarction.
Casullo J, Semionov A
Acta Radiol 2013 Jun;54(5):505-10. Epub 2013 Apr 30 doi: 10.1177/0284185113475797. PMID: 23395814
Kidney neoplasms: renal halo sign after percutaneous radiofrequency ablation--incidence and clinical importance in 101 consecutive patients.
Schirmang TC, Mayo-Smith WW, Dupuy DE, Beland MD, Grand DJ
Radiology 2009 Oct;253(1):263-9. Epub 2009 Jul 31 doi: 10.1148/radiol.2531082257. PMID: 19703853

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