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Refractory Primary Myelofibrosis

MedGen UID:
1740721
•Concept ID:
C5419092
•
Neoplastic Process

Definition

Primary myelofibrosis that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Primary Myelofibrosis

Professional guidelines

PubMed

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Next Generation Therapeutics for the Treatment of Myelofibrosis.
Tremblay D, Mascarenhas J
Cells 2021 Apr 27;10(5) doi: 10.3390/cells10051034. PMID: 33925695Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Recent clinical studies

Etiology

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Splenectomy in Myelofibrosis: Indications, Efficacy, and Complications.
Malato A, Rossi E, Tiribelli M, Mendicino F, Pugliese N
Clin Lymphoma Myeloma Leuk 2020 Sep;20(9):588-595. Epub 2020 Apr 30 doi: 10.1016/j.clml.2020.04.015. PMID: 32482540
Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2016 Dec;91(12):1262-1271. doi: 10.1002/ajh.24592. PMID: 27870387
Alleviating anemia and thrombocytopenia in myelofibrosis patients.
Cervantes F, Correa JG, Hernandez-Boluda JC
Expert Rev Hematol 2016 May;9(5):489-96. Epub 2016 Mar 2 doi: 10.1586/17474086.2016.1154452. PMID: 26891375

Diagnosis

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2016 Dec;91(12):1262-1271. doi: 10.1002/ajh.24592. PMID: 27870387
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007
Primary myelofibrosis: 2012 update on diagnosis, risk stratification, and management.
Tefferi A
Am J Hematol 2011 Dec;86(12):1017-26. doi: 10.1002/ajh.22210. PMID: 22086865

Therapy

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Next Generation Therapeutics for the Treatment of Myelofibrosis.
Tremblay D, Mascarenhas J
Cells 2021 Apr 27;10(5) doi: 10.3390/cells10051034. PMID: 33925695Free PMC Article
Splenectomy in Myelofibrosis: Indications, Efficacy, and Complications.
Malato A, Rossi E, Tiribelli M, Mendicino F, Pugliese N
Clin Lymphoma Myeloma Leuk 2020 Sep;20(9):588-595. Epub 2020 Apr 30 doi: 10.1016/j.clml.2020.04.015. PMID: 32482540
Alleviating anemia and thrombocytopenia in myelofibrosis patients.
Cervantes F, Correa JG, Hernandez-Boluda JC
Expert Rev Hematol 2016 May;9(5):489-96. Epub 2016 Mar 2 doi: 10.1586/17474086.2016.1154452. PMID: 26891375
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007

Prognosis

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2016 Dec;91(12):1262-1271. doi: 10.1002/ajh.24592. PMID: 27870387
Alleviating anemia and thrombocytopenia in myelofibrosis patients.
Cervantes F, Correa JG, Hernandez-Boluda JC
Expert Rev Hematol 2016 May;9(5):489-96. Epub 2016 Mar 2 doi: 10.1586/17474086.2016.1154452. PMID: 26891375
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007

Clinical prediction guides

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2016 Dec;91(12):1262-1271. doi: 10.1002/ajh.24592. PMID: 27870387
Alleviating anemia and thrombocytopenia in myelofibrosis patients.
Cervantes F, Correa JG, Hernandez-Boluda JC
Expert Rev Hematol 2016 May;9(5):489-96. Epub 2016 Mar 2 doi: 10.1586/17474086.2016.1154452. PMID: 26891375
Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007

Recent systematic reviews

Indication and management of allogeneic stem cell transplantation in primary myelofibrosis: a consensus process by an EBMT/ELN international working group.
Kröger NM, Deeg JH, Olavarria E, Niederwieser D, Bacigalupo A, Barbui T, Rambaldi A, Mesa R, Tefferi A, Griesshammer M, Gupta V, Harrison C, Alchalby H, Vannucchi AM, Cervantes F, Robin M, Ditschkowski M, Fauble V, McLornan D, Ballen K, Popat UR, Passamonti F, Rondelli D, Barosi G
Leukemia 2015 Nov;29(11):2126-33. Epub 2015 Aug 21 doi: 10.1038/leu.2015.233. PMID: 26293647

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