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Acquired aplastic anemia

MedGen UID:
543648
•Concept ID:
C0271907
•
Disease or Syndrome
Synonyms: acquired aplastic anemia; Idiopathic acquired aplastic anemia; rare acquired aplastic anaemia; rare acquired aplastic anemia; Rare acquired aplastic anemia
SNOMED CT: Acquired aplastic anemia (55907008); Idiopathic acquired aplastic anemia (55907008)
 
Monarch Initiative: MONDO:0015610
Orphanet: ORPHA164823

Definition

An instance of aplastic anemia that is acquired during the lifetime of the individual. [from MONDO]

Professional guidelines

PubMed

Aplastic anemia: history and recent developments in diagnosis and treatment.
Onishi Y
Int J Hematol 2024 Mar;119(3):217-219. Epub 2024 Feb 4 doi: 10.1007/s12185-024-03715-1. PMID: 38310173
Recent advances in the diagnosis and treatment of pediatric acquired aplastic anemia.
Yoshida N
Int J Hematol 2024 Mar;119(3):240-247. Epub 2023 Mar 3 doi: 10.1007/s12185-023-03564-4. PMID: 36867357
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article

Recent clinical studies

Etiology

Aplastic anemia: Pathophysiology.
Giudice V, Selleri C
Semin Hematol 2022 Jan;59(1):13-20. Epub 2022 Jan 5 doi: 10.1053/j.seminhematol.2021.12.002. PMID: 35491054
Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.
Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS
N Engl J Med 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878. PMID: 28423296Free PMC Article
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.
Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Biancotto A, Wu CO, Young NS
N Engl J Med 2011 Aug 4;365(5):430-8. doi: 10.1056/NEJMoa1103975. PMID: 21812672Free PMC Article

Diagnosis

Recent advances in the diagnosis and treatment of pediatric acquired aplastic anemia.
Yoshida N
Int J Hematol 2024 Mar;119(3):240-247. Epub 2023 Mar 3 doi: 10.1007/s12185-023-03564-4. PMID: 36867357
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article
How I treat acquired aplastic anemia.
Bacigalupo A
Blood 2017 Mar 16;129(11):1428-1436. Epub 2017 Jan 17 doi: 10.1182/blood-2016-08-693481. PMID: 28096088
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Acquired aplastic anemia in children.
Hartung HD, Olson TS, Bessler M
Pediatr Clin North Am 2013 Dec;60(6):1311-36. Epub 2013 Oct 16 doi: 10.1016/j.pcl.2013.08.011. PMID: 24237973Free PMC Article

Therapy

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article
Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.
Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS
N Engl J Med 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878. PMID: 28423296Free PMC Article
How I treat acquired aplastic anemia.
Bacigalupo A
Blood 2017 Mar 16;129(11):1428-1436. Epub 2017 Jan 17 doi: 10.1182/blood-2016-08-693481. PMID: 28096088
Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.
Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Biancotto A, Wu CO, Young NS
N Engl J Med 2011 Aug 4;365(5):430-8. doi: 10.1056/NEJMoa1103975. PMID: 21812672Free PMC Article

Prognosis

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV
Curr Treat Options Oncol 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. PMID: 29143887Free PMC Article
How I treat acquired aplastic anemia.
Bacigalupo A
Blood 2017 Mar 16;129(11):1428-1436. Epub 2017 Jan 17 doi: 10.1182/blood-2016-08-693481. PMID: 28096088
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Acquired aplastic anemia in children.
Hartung HD, Olson TS, Bessler M
Pediatr Clin North Am 2013 Dec;60(6):1311-36. Epub 2013 Oct 16 doi: 10.1016/j.pcl.2013.08.011. PMID: 24237973Free PMC Article

Clinical prediction guides

The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target.
Risitano AM, Frieri C, Urciuoli E, Marano L
Immunol Rev 2023 Jan;313(1):262-278. Epub 2022 Sep 15 doi: 10.1111/imr.13137. PMID: 36110036Free PMC Article
Hepatitis-Associated Aplastic Anemia.
Alshaibani A, Dufour C, Risitano A, de Latour R, Aljurf M
Hematol Oncol Stem Cell Ther 2022 Jun 1;15(2):8-12. doi: 10.1016/j.hemonc.2020.10.001. PMID: 33197413
How I treat acquired aplastic anemia.
Bacigalupo A
Blood 2017 Mar 16;129(11):1428-1436. Epub 2017 Jan 17 doi: 10.1182/blood-2016-08-693481. PMID: 28096088
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.
Scheinberg P, Nunez O, Weinstein B, Scheinberg P, Biancotto A, Wu CO, Young NS
N Engl J Med 2011 Aug 4;365(5):430-8. doi: 10.1056/NEJMoa1103975. PMID: 21812672Free PMC Article

Recent systematic reviews

Androgen use in bone marrow failures and myeloid neoplasms: Mechanisms of action and a systematic review of clinical data.
Bosi A, Barcellini W, Passamonti F, Fattizzo B
Blood Rev 2023 Nov;62:101132. Epub 2023 Sep 9 doi: 10.1016/j.blre.2023.101132. PMID: 37709654
Long-term effects of hematopoietic growth factors in aplastic anemia patients treated with immunosuppression: Meta-analysis of randomized controlled trials.
Wang A, Su D, Luo J, Fu Y, Li Q, Chen S
Medicine (Baltimore) 2022 Oct 21;101(42):e31103. doi: 10.1097/MD.0000000000031103. PMID: 36281138Free PMC Article
Allo-HSCT compared with immunosuppressive therapy for acquired aplastic anemia: a system review and meta-analysis.
Zhu Y, Gao Q, Hu J, Liu X, Guan D, Zhang F
BMC Immunol 2020 Mar 6;21(1):10. doi: 10.1186/s12865-020-0340-x. PMID: 32138642Free PMC Article
The Risk of Clonal Evolution of Granulocyte Colony-Stimulating Factor for Acquired Aplastic Anemia: A Systematic Review and Meta-Analysis.
Ding SX, Chen T, Wang T, Liu CY, Lu WL, Fu R
Acta Haematol 2018;140(3):141-145. Epub 2018 Sep 25 doi: 10.1159/000491816. PMID: 30253387
Systematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function.
Gonzalez-Casas R, Garcia-Buey L, Jones EA, Gisbert JP, Moreno-Otero R
Aliment Pharmacol Ther 2009 Sep 1;30(5):436-43. Epub 2009 Jun 9 doi: 10.1111/j.1365-2036.2009.04060.x. PMID: 19508613

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