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COVID-19-Associated Encephalitis

MedGen UID:
1741717
•Concept ID:
C5419166
•
Disease or Syndrome
Synonym: SARS-CoV-2 -Associated Encephalitis

Definition

Encephalitis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCOVID-19-Associated Encephalitis

Professional guidelines

PubMed

Acute central and peripheral nervous system injury associated with coronavirus disease 2019: recognition and treatment strategies.
Simon DW, Schober ME
Curr Opin Pediatr 2021 Dec 1;33(6):591-596. doi: 10.1097/MOP.0000000000001070. PMID: 34670263Free PMC Article

Recent clinical studies

Etiology

Clinical features and virologic lineages of COVID-19-associated encephalitis in Taiwanese children during early epidemic wave of omicron in 2022: Report from a medical center.
Chang YJ, Huang CG, Shie SS, Lin JJ, Chen CJ
J Microbiol Immunol Infect 2024 Feb;57(1):48-54. Epub 2023 Oct 29 doi: 10.1016/j.jmii.2023.10.005. PMID: 37926632
Risk factors of Omicron variant associated acute encephalitis/encephalopathy in children.
Huang CW, Lin JJ, Kuo CY, Lin KL, Huang YC, Chiu CH, Chen YC, Chen CH, Hsieh YC
J Microbiol Immunol Infect 2023 Dec;56(6):1169-1177. Epub 2023 Sep 4 doi: 10.1016/j.jmii.2023.08.010. PMID: 37709632

Diagnosis

Clinical features and virologic lineages of COVID-19-associated encephalitis in Taiwanese children during early epidemic wave of omicron in 2022: Report from a medical center.
Chang YJ, Huang CG, Shie SS, Lin JJ, Chen CJ
J Microbiol Immunol Infect 2024 Feb;57(1):48-54. Epub 2023 Oct 29 doi: 10.1016/j.jmii.2023.10.005. PMID: 37926632
Catching hold of COVID-19-related encephalitis by tracking ANGPTL4 signature in blood: An Editorial Highlight for "Endothelial cell biomarkers in critically ill COVID-19-patients with encephalitis": An Editorial Highlight for "Endothelial cell biomarkers in critically ill COVID-19-patients with encephalitis" on page 492.
Chakraborty S, Basu A
J Neurochem 2022 Jun;161(6):458-462. Epub 2021 Dec 29 doi: 10.1111/jnc.15560. PMID: 34967002
COVID-19-associated encephalitis or Creutzfeldt-Jakob disease: a case report.
Tayyebi G, Malakouti SK, Shariati B, Kamalzadeh L
Neurodegener Dis Manag 2022 Feb;12(1):29-34. Epub 2021 Dec 2 doi: 10.2217/nmt-2021-0025. PMID: 34854312Free PMC Article
Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully.
Kamal YM, Abdelmajid Y, Al Madani AAR
BMJ Case Rep 2020 Sep 16;13(9) doi: 10.1136/bcr-2020-237378. PMID: 32938656Free PMC Article
COVID-19-Associated Encephalitis Mimicking Glial Tumor.
Efe IE, Aydin OU, Alabulut A, Celik O, Aydin K
World Neurosurg 2020 Aug;140:46-48. Epub 2020 May 29 doi: 10.1016/j.wneu.2020.05.194. PMID: 32479911Free PMC Article

Therapy

Clinical symptoms, diagnosis, treatment, and outcome of COVID-19-associated encephalitis: A systematic review of case reports and case series.
Koupaei M, Shadab Mehr N, Mohamadi MH, Asadi A, Abbasimoghaddam S, Shekartabar A, Heidary M, Shokri F
J Clin Lab Anal 2022 May;36(5):e24426. Epub 2022 Apr 18 doi: 10.1002/jcla.24426. PMID: 35435264Free PMC Article

Prognosis

Risk factors of Omicron variant associated acute encephalitis/encephalopathy in children.
Huang CW, Lin JJ, Kuo CY, Lin KL, Huang YC, Chiu CH, Chen YC, Chen CH, Hsieh YC
J Microbiol Immunol Infect 2023 Dec;56(6):1169-1177. Epub 2023 Sep 4 doi: 10.1016/j.jmii.2023.08.010. PMID: 37709632
Catching hold of COVID-19-related encephalitis by tracking ANGPTL4 signature in blood: An Editorial Highlight for "Endothelial cell biomarkers in critically ill COVID-19-patients with encephalitis": An Editorial Highlight for "Endothelial cell biomarkers in critically ill COVID-19-patients with encephalitis" on page 492.
Chakraborty S, Basu A
J Neurochem 2022 Jun;161(6):458-462. Epub 2021 Dec 29 doi: 10.1111/jnc.15560. PMID: 34967002
COVID-19 Associated With Encephalitis: Case Report and Review of Literature.
Meshref M, Hewila IM, Abdel Mageed S, Morra ME
Neurologist 2021 Nov 4;26(6):268-270. doi: 10.1097/NRL.0000000000000347. PMID: 34734905Free PMC Article
MENINGO-ENCEPHALITIS IN A MIDDLE-AGED WOMAN HOSPITALIZED FOR COVID-19.
Dyachenko PA, Smiianova OI, Dyachenko AG
Wiad Lek 2021;74(5):1274-1276. PMID: 34090304

Clinical prediction guides

Catching hold of COVID-19-related encephalitis by tracking ANGPTL4 signature in blood: An Editorial Highlight for "Endothelial cell biomarkers in critically ill COVID-19-patients with encephalitis": An Editorial Highlight for "Endothelial cell biomarkers in critically ill COVID-19-patients with encephalitis" on page 492.
Chakraborty S, Basu A
J Neurochem 2022 Jun;161(6):458-462. Epub 2021 Dec 29 doi: 10.1111/jnc.15560. PMID: 34967002

Recent systematic reviews

Clinical symptoms, diagnosis, treatment, and outcome of COVID-19-associated encephalitis: A systematic review of case reports and case series.
Koupaei M, Shadab Mehr N, Mohamadi MH, Asadi A, Abbasimoghaddam S, Shekartabar A, Heidary M, Shokri F
J Clin Lab Anal 2022 May;36(5):e24426. Epub 2022 Apr 18 doi: 10.1002/jcla.24426. PMID: 35435264Free PMC Article
Central neuroinflammation in Covid-19: a systematic review of 182 cases with encephalitis, acute disseminated encephalomyelitis, and necrotizing encephalopathies.
Zamani R, Pouremamali R, Rezaei N
Rev Neurosci 2022 Jun 27;33(4):397-412. Epub 2021 Sep 17 doi: 10.1515/revneuro-2021-0082. PMID: 34536341

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