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COVID-19-Associated Nervous System Disorder

MedGen UID:
1776032
•Concept ID:
C5419165
•
Disease or Syndrome
Synonym: SARS-CoV-2 -Associated Nervous System Disorder

Definition

A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [from NCI]

Professional guidelines

PubMed

Longitudinal analysis and treatment of neuropsychiatric symptoms in post-acute sequelae of COVID-19.
Liu EN, Yang JH, Patel L, Arora J, Gooding A, Ellis R, Graves JS
J Neurol 2023 Oct;270(10):4661-4672. Epub 2023 Jul 26 doi: 10.1007/s00415-023-11885-x. PMID: 37493802Free PMC Article
Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management.
Sampaio Rocha-Filho PA
Headache 2022 Jun;62(6):650-656. Epub 2022 May 11 doi: 10.1111/head.14319. PMID: 35545780Free PMC Article
Mucormycosis in COVID-19 patients: predisposing factors, prevention and management.
Rudrabhatla PK, Reghukumar A, Thomas SV
Acta Neurol Belg 2022 Apr;122(2):273-280. Epub 2021 Nov 24 doi: 10.1007/s13760-021-01840-w. PMID: 34820787Free PMC Article

Recent clinical studies

Etiology

COVID-19 and Cerebrovascular Disease.
Catherine C, Veitinger J, Chou SH
Semin Neurol 2023 Apr;43(2):219-228. Epub 2023 May 22 doi: 10.1055/s-0043-1768475. PMID: 37216977
Neurological Sequelae of COVID-19.
Ahmad SJ, Feigen CM, Vazquez JP, Kobets AJ, Altschul DJ
J Integr Neurosci 2022 Apr 6;21(3):77. doi: 10.31083/j.jin2103077. PMID: 35633158
COVID-19 associated cognitive impairment: A systematic review.
Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P
Cortex 2022 Jul;152:77-97. Epub 2022 Apr 18 doi: 10.1016/j.cortex.2022.04.006. PMID: 35537236Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
COVID-19-associated Diffuse Leukoencephalopathy and Microhemorrhages.
Radmanesh A, Derman A, Lui YW, Raz E, Loh JP, Hagiwara M, Borja MJ, Zan E, Fatterpekar GM
Radiology 2020 Oct;297(1):E223-E227. Epub 2020 May 21 doi: 10.1148/radiol.2020202040. PMID: 32437314Free PMC Article

Diagnosis

COVID-19 associated myopathy.
Aschman T, Stenzel W
Curr Opin Neurol 2022 Oct 1;35(5):622-628. Epub 2022 Aug 11 doi: 10.1097/WCO.0000000000001101. PMID: 35950722
Malnutrition and Sarcopenia in COVID-19 Survivors.
Grund S, Bauer JM
Clin Geriatr Med 2022 Aug;38(3):559-564. Epub 2022 Apr 21 doi: 10.1016/j.cger.2022.04.001. PMID: 35868673Free PMC Article
COVID-19-associated Parotid Gland Abscess.
Friedrich RE, Droste TL, Angerer F, Popa B, Koehnke R, Gosau M, Knipfer C
In Vivo 2022 May-Jun;36(3):1349-1353. doi: 10.21873/invivo.12837. PMID: 35478161Free PMC Article
Cardiovascular complications of COVID-19.
Farshidfar F, Koleini N, Ardehali H
JCI Insight 2021 Jul 8;6(13) doi: 10.1172/jci.insight.148980. PMID: 34061779Free PMC Article
COVID-19 associated anxiety enhances tinnitus.
Xia L, He G, Feng Y, Yu X, Zhao X, Yin S, Chen Z, Wang J, Fan J, Dong C
PLoS One 2021;16(2):e0246328. Epub 2021 Feb 5 doi: 10.1371/journal.pone.0246328. PMID: 33544744Free PMC Article

Therapy

COVID-19 and the peripheral nervous system. A 2-year review from the pandemic to the vaccine era.
Taga A, Lauria G
J Peripher Nerv Syst 2022 Mar;27(1):4-30. Epub 2022 Mar 14 doi: 10.1111/jns.12482. PMID: 35137496Free PMC Article
Psychotropics and COVID-19: An analysis of safety and prophylaxis.
Javelot H, Straczek C, Meyer G, Gitahy Falcao Faria C, Weiner L, Drapier D, Fakra E, Fossati P, Weibel S, Dizet S, Langrée B, Masson M, Gaillard R, Leboyer M, Llorca PM, Hingray C, Haffen E, Yrondi A
Encephale 2021 Dec;47(6):564-588. Epub 2021 Sep 2 doi: 10.1016/j.encep.2021.08.002. PMID: 34548153Free PMC Article
Cerebral venous thrombosis in COVID-19.
Ghosh R, Roy D, Mandal A, Pal SK, Chandra Swaika B, Naga D, Pandit A, Ray BK, Benito-León J
Diabetes Metab Syndr 2021 May-Jun;15(3):1039-1045. Epub 2021 May 18 doi: 10.1016/j.dsx.2021.04.026. PMID: 34015627Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
COVID-19 and MS disease-modifying therapies.
Berger JR, Brandstadter R, Bar-Or A
Neurol Neuroimmunol Neuroinflamm 2020 Jul;7(4) Epub 2020 May 15 doi: 10.1212/NXI.0000000000000761. PMID: 32414755Free PMC Article

Prognosis

COVID-19-Associated Chemosensory Loss Continues to Decline.
Reiter ER, Coelho DH, French E, Costanzo RM; N3C Consortium
Otolaryngol Head Neck Surg 2023 Nov;169(5):1386-1389. Epub 2023 May 26 doi: 10.1002/ohn.384. PMID: 37232470Free PMC Article
COVID-19 and Cerebrovascular Disease.
Catherine C, Veitinger J, Chou SH
Semin Neurol 2023 Apr;43(2):219-228. Epub 2023 May 22 doi: 10.1055/s-0043-1768475. PMID: 37216977
Proteomic and phosphoproteomic characteristics of the cortex, hippocampus, thalamus, lung, and kidney in COVID-19-infected female K18-hACE2 mice.
Liu JF, Peng WJ, Wu Y, Yang YH, Wu SF, Liu DP, Liu JN, Yang JT
EBioMedicine 2023 Apr;90:104518. Epub 2023 Mar 16 doi: 10.1016/j.ebiom.2023.104518. PMID: 36933413Free PMC Article
Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M
J Neurol 2021 Apr;268(4):1133-1170. Epub 2020 Aug 25 doi: 10.1007/s00415-020-10124-x. PMID: 32840686Free PMC Article
COVID-19-associated Guillain-Barré syndrome: The early pandemic experience.
Caress JB, Castoro RJ, Simmons Z, Scelsa SN, Lewis RA, Ahlawat A, Narayanaswami P
Muscle Nerve 2020 Oct;62(4):485-491. Epub 2020 Aug 11 doi: 10.1002/mus.27024. PMID: 32678460Free PMC Article

Clinical prediction guides

Proteomic and phosphoproteomic characteristics of the cortex, hippocampus, thalamus, lung, and kidney in COVID-19-infected female K18-hACE2 mice.
Liu JF, Peng WJ, Wu Y, Yang YH, Wu SF, Liu DP, Liu JN, Yang JT
EBioMedicine 2023 Apr;90:104518. Epub 2023 Mar 16 doi: 10.1016/j.ebiom.2023.104518. PMID: 36933413Free PMC Article
COVID-19 associated cognitive impairment: A systematic review.
Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P
Cortex 2022 Jul;152:77-97. Epub 2022 Apr 18 doi: 10.1016/j.cortex.2022.04.006. PMID: 35537236Free PMC Article
COVID-19 associated nervous system manifestations.
Khatoon F, Prasad K, Kumar V
Sleep Med 2022 Mar;91:231-236. Epub 2021 Jul 9 doi: 10.1016/j.sleep.2021.07.005. PMID: 34321155Free PMC Article
Emerging neurotropic features of SARS-CoV-2.
Zhan WR, Huang J, Zeng PM, Tian WY, Luo ZG
J Mol Cell Biol 2021 Dec 30;13(10):705-711. doi: 10.1093/jmcb/mjab044. PMID: 34289037Free PMC Article
Cardiovascular complications of COVID-19.
Farshidfar F, Koleini N, Ardehali H
JCI Insight 2021 Jul 8;6(13) doi: 10.1172/jci.insight.148980. PMID: 34061779Free PMC Article

Recent systematic reviews

COVID-19 associated cognitive impairment: A systematic review.
Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P
Cortex 2022 Jul;152:77-97. Epub 2022 Apr 18 doi: 10.1016/j.cortex.2022.04.006. PMID: 35537236Free PMC Article
Status epilepticus and COVID-19: A systematic review.
Dono F, Nucera B, Lanzone J, Evangelista G, Rinaldi F, Speranza R, Troisi S, Tinti L, Russo M, Di Pietro M, Onofrj M, Bonanni L, Assenza G, Vollono C, Anzellotti F, Brigo F
Epilepsy Behav 2021 May;118:107887. Epub 2021 Mar 17 doi: 10.1016/j.yebeh.2021.107887. PMID: 33743344Free PMC Article
COVID-19 associated central nervous system manifestations, mental and neurological symptoms: a systematic review and meta-analysis.
Soltani S, Tabibzadeh A, Zakeri A, Zakeri AM, Latifi T, Shabani M, Pouremamali A, Erfani Y, Pakzad I, Malekifar P, Valizadeh R, Zandi M, Pakzad R
Rev Neurosci 2021 Apr 27;32(3):351-361. Epub 2021 Jan 13 doi: 10.1515/revneuro-2020-0108. PMID: 33618441
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M
J Neurol 2021 Apr;268(4):1133-1170. Epub 2020 Aug 25 doi: 10.1007/s00415-020-10124-x. PMID: 32840686Free PMC Article

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