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Locally Advanced Esophageal Squamous Cell Carcinoma

MedGen UID:
1745399
•Concept ID:
C5419605
•
Neoplastic Process

Definition

Esophageal squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Esophageal Squamous Cell Carcinoma

Professional guidelines

PubMed

Prognostic factors associated with (18)FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment.
Feng WH, Chen YY, Kuo YS, Lin KH, Tsai YM, Wu TH, Huang HK, Huang TW
BMC Cancer 2022 Jul 14;22(1):768. doi: 10.1186/s12885-022-09852-2. PMID: 35836202Free PMC Article
Treatment strategies and outcomes for elderly patients with locally advanced squamous cell carcinoma of the esophagus.
Kozuki R, Watanabe M, Toihata T, Takahashi K, Otake R, Okamura A, Imamura Y, Mine S
Surg Today 2022 Mar;52(3):377-384. Epub 2021 Jul 30 doi: 10.1007/s00595-021-02348-9. PMID: 34331129
The current status of multimodality treatment for unresectable locally advanced esophageal squamous cell carcinoma.
Hirano H, Boku N
Asia Pac J Clin Oncol 2018 Aug;14(4):291-299. Epub 2018 Jun 5 doi: 10.1111/ajco.12995. PMID: 29873183

Recent clinical studies

Etiology

Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial.
Tang H, Wang H, Fang Y, Zhu JY, Yin J, Shen YX, Zeng ZC, Jiang DX, Hou YY, Du M, Lian CH, Zhao Q, Jiang HJ, Gong L, Li ZG, Liu J, Xie DY, Li WF, Chen C, Zheng B, Chen KN, Dai L, Liao YD, Li K, Li HC, Zhao NQ, Tan LJ
Ann Oncol 2023 Feb;34(2):163-172. Epub 2022 Nov 15 doi: 10.1016/j.annonc.2022.10.508. PMID: 36400384
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J
JAMA Surg 2021 Aug 1;156(8):721-729. doi: 10.1001/jamasurg.2021.2373. PMID: 34160577Free PMC Article
Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.
Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y, Zeng Z, Zhu J, Hou Y, Du M, Jiao J, Jiang H, Gong L, Li Z, Liu J, Xie D, Li W, Lian C, Zhao Q, Chen C, Zheng B, Liao Y, Li K, Li H, Wu H, Dai L, Chen KN
JAMA Surg 2021 May 1;156(5):444-451. doi: 10.1001/jamasurg.2021.0133. PMID: 33729467Free PMC Article
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Diagnosis

Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Xu J, Cai Y, Hong Z, Duan H, Ke S
Int J Surg 2024 Jan 1;110(1):490-506. doi: 10.1097/JS9.0000000000000816. PMID: 37800587Free PMC Article
Real-world treatment patterns and survival for locally advanced esophageal squamous cell carcinoma.
Luo HC, Wu JJ, Zhu LJ, Cai LJ, Feng J, Shen ZY, Wu MJ, Chen FF, Fu ZC, Xie FW
Medicine (Baltimore) 2023 Aug 25;102(34):e34647. doi: 10.1097/MD.0000000000034647. PMID: 37653737Free PMC Article
Concurrent chemoradiotherapy with S-1 compared with concurrent chemoradiotherapy with docetaxel and cisplatin for locally advanced esophageal squamous cell carcinoma.
Zhou XL, Yu CH, Wang WW, Ji FZ, Xiong YZ, Zhu WG, Tong YS
Radiat Oncol 2021 May 26;16(1):94. doi: 10.1186/s13014-021-01821-6. PMID: 34039375Free PMC Article
Safety and Feasibility of Radiotherapy Plus Camrelizumab for Locally Advanced Esophageal Squamous Cell Carcinoma.
Zhang W, Yan C, Gao X, Li X, Cao F, Zhao G, Zhao J, Er P, Zhang T, Chen X, Wang Y, Jiang Y, Wang Q, Zhang B, Qian D, Wang J, Zhou D, Ren X, Yu Z, Zhao L, Yuan Z, Wang P, Pang Q
Oncologist 2021 Jul;26(7):e1110-e1124. Epub 2021 Jun 5 doi: 10.1002/onco.13797. PMID: 33893689Free PMC Article
Genome-wide and size-based cell-free DNA indices as predictive biomarkers for locally advanced esophageal squamous cell carcinoma treated with preoperative or definitive chemoradiotherapy.
Kim EJ, Im HS, Lee J, Cho EH, Kim YH, Kim HR, Kim JH, Park SR
Curr Probl Cancer 2021 Jun;45(3):100685. Epub 2020 Nov 28 doi: 10.1016/j.currproblcancer.2020.100685. PMID: 33342577

Therapy

Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial.
Tang H, Wang H, Fang Y, Zhu JY, Yin J, Shen YX, Zeng ZC, Jiang DX, Hou YY, Du M, Lian CH, Zhao Q, Jiang HJ, Gong L, Li ZG, Liu J, Xie DY, Li WF, Chen C, Zheng B, Chen KN, Dai L, Liao YD, Li K, Li HC, Zhao NQ, Tan LJ
Ann Oncol 2023 Feb;34(2):163-172. Epub 2022 Nov 15 doi: 10.1016/j.annonc.2022.10.508. PMID: 36400384
Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma.
Liu J, Yang Y, Liu Z, Fu X, Cai X, Li H, Zhu L, Shen Y, Zhang H, Sun Y, Chen H, Yu B, Zhang R, Shao J, Zhang M, Li Z
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-004291. PMID: 35338088Free PMC Article
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J
JAMA Surg 2021 Aug 1;156(8):721-729. doi: 10.1001/jamasurg.2021.2373. PMID: 34160577Free PMC Article
Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.
Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y, Zeng Z, Zhu J, Hou Y, Du M, Jiao J, Jiang H, Gong L, Li Z, Liu J, Xie D, Li W, Lian C, Zhao Q, Chen C, Zheng B, Liao Y, Li K, Li H, Wu H, Dai L, Chen KN
JAMA Surg 2021 May 1;156(5):444-451. doi: 10.1001/jamasurg.2021.0133. PMID: 33729467Free PMC Article
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article

Prognosis

Durvalumab and tremelimumab with definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.
Park S, Oh D, Choi YL, Chi SA, Kim K, Ahn MJ, Sun JM
Cancer 2022 Jun 1;128(11):2148-2158. Epub 2022 Mar 23 doi: 10.1002/cncr.34176. PMID: 35319779
Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma: The NEOCRTEC5010 Randomized Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J
JAMA Surg 2021 Aug 1;156(8):721-729. doi: 10.1001/jamasurg.2021.2373. PMID: 34160577Free PMC Article
Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial.
Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y, Zeng Z, Zhu J, Hou Y, Du M, Jiao J, Jiang H, Gong L, Li Z, Liu J, Xie D, Li W, Lian C, Zhao Q, Chen C, Zheng B, Liao Y, Li K, Li H, Wu H, Dai L, Chen KN
JAMA Surg 2021 May 1;156(5):444-451. doi: 10.1001/jamasurg.2021.0133. PMID: 33729467Free PMC Article
Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J; AME Thoracic Surgery Collaborative Group
J Clin Oncol 2018 Sep 20;36(27):2796-2803. Epub 2018 Aug 8 doi: 10.1200/JCO.2018.79.1483. PMID: 30089078Free PMC Article
A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907).
Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, Ikeda K, Kanda T, Tsujinaka T, Nakamura K, Fukuda H
Ann Surg Oncol 2012 Jan;19(1):68-74. Epub 2011 Aug 31 doi: 10.1245/s10434-011-2049-9. PMID: 21879261

Clinical prediction guides

Neoadjuvant camrelizumab combined with paclitaxel and nedaplatin for locally advanced esophageal squamous cell carcinoma: a single-arm phase 2 study (cohort study).
Yang Y, Zhang J, Meng H, Ling X, Wang X, Xin Y, Jiang H, Zhang L, Fang C, Liang H, Ma J, Zhu J
Int J Surg 2024 Mar 1;110(3):1430-1440. doi: 10.1097/JS9.0000000000000978. PMID: 38051925Free PMC Article
Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma.
Habu T, Kumanishi R, Ogata T, Fujisawa T, Mishima S, Kotani D, Kadowaki S, Nakamura M, Hojo H, Fujiwara H, Kumagai S, Koyama S, Fujita T, Kinoshita T, Nishikawa H, Yano T, Tajika M, Muro K, Mitsunaga S, Kojima T, Bando H
Esophagus 2023 Jul;20(3):533-540. Epub 2023 Feb 8 doi: 10.1007/s10388-023-00987-0. PMID: 36750480
Clinical outcomes and toxicities of locally advanced esophageal squamous cell carcinoma patients treated with early thoracic radiation therapy after induction chemotherapy.
Qiu J, Lin H, Yu Y, Ke D, Li H, Zheng H, Zheng Q, Wang Z, Lin M, Yang J, Liu L, Zhang M, Liu T, Wu Y, Li J, Lai J
Int J Clin Oncol 2023 Apr;28(4):550-564. Epub 2023 Feb 3 doi: 10.1007/s10147-023-02299-w. PMID: 36735115
Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial.
Tang H, Wang H, Fang Y, Zhu JY, Yin J, Shen YX, Zeng ZC, Jiang DX, Hou YY, Du M, Lian CH, Zhao Q, Jiang HJ, Gong L, Li ZG, Liu J, Xie DY, Li WF, Chen C, Zheng B, Chen KN, Dai L, Liao YD, Li K, Li HC, Zhao NQ, Tan LJ
Ann Oncol 2023 Feb;34(2):163-172. Epub 2022 Nov 15 doi: 10.1016/j.annonc.2022.10.508. PMID: 36400384
Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.
Tsuchiya N, Kunisaki C, Sato S, Tanaka Y, Sato K, Watanabe J, Takeda K, Kosaka T, Akiyama H, Endo I
Langenbecks Arch Surg 2022 Aug;407(5):1911-1921. Epub 2022 Mar 1 doi: 10.1007/s00423-022-02445-4. PMID: 35230525

Recent systematic reviews

A commentary on 'Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis'.
Qiao L, Liu Y, Ge D, Jiang S
Int J Surg 2024 May 1;110(5):3118-3119. doi: 10.1097/JS9.0000000000001211. PMID: 38363989Free PMC Article
Comparison of efficacy and safety between neoadjuvant chemotherapy and neoadjuvant immune checkpoint inhibitors combined with chemotherapy for locally advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis.
Xu J, Cai Y, Hong Z, Duan H, Ke S
Int J Surg 2024 Jan 1;110(1):490-506. doi: 10.1097/JS9.0000000000000816. PMID: 37800587Free PMC Article
The efficacy and safety of neoadjuvant immunotherapy in resectable locally advanced esophageal squamous cell carcinoma: A systematic review and meta-analysis.
He W, Wang C, Li C, Nie X, Li H, Li J, Zhao N, Chen H, Miao X, Han Y, Peng L, Leng X
Front Immunol 2023;14:1118902. Epub 2023 Feb 17 doi: 10.3389/fimmu.2023.1118902. PMID: 36875107Free PMC Article
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article

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