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Resectable Skin Squamous Cell Carcinoma

MedGen UID:
1746207
•Concept ID:
C5418570
•
Neoplastic Process

Definition

Skin squamous cell carcinoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Skin Squamous Cell Carcinoma

Professional guidelines

PubMed

Update in the treatment of non-melanoma skin cancers: the use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma.
Ascierto PA, Schadendorf D
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005082. PMID: 36455990Free PMC Article
Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline.
Likhacheva A, Awan M, Barker CA, Bhatnagar A, Bradfield L, Brady MS, Buzurovic I, Geiger JL, Parvathaneni U, Zaky S, Devlin PM
Pract Radiat Oncol 2020 Jan-Feb;10(1):8-20. Epub 2019 Dec 9 doi: 10.1016/j.prro.2019.10.014. PMID: 31831330
Medical treatment of advanced cutaneous squamous-cell carcinoma.
Gellrich FF, Hüning S, Beissert S, Eigentler T, Stockfleth E, Gutzmer R, Meier F
J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:38-43. doi: 10.1111/jdv.16024. PMID: 31833610

Recent clinical studies

Etiology

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Update in the treatment of non-melanoma skin cancers: the use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma.
Ascierto PA, Schadendorf D
J Immunother Cancer 2022 Dec;10(12) doi: 10.1136/jitc-2022-005082. PMID: 36455990Free PMC Article
Adjuvant therapy for high-risk cutaneous squamous cell carcinoma: 10-year review.
Newman JG, Hall MA, Kurley SJ, Cook RW, Farberg AS, Geiger JL, Koyfman SA
Head Neck 2021 Sep;43(9):2822-2843. Epub 2021 Jun 7 doi: 10.1002/hed.26767. PMID: 34096664Free PMC Article
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Medical treatment of advanced cutaneous squamous-cell carcinoma.
Gellrich FF, Hüning S, Beissert S, Eigentler T, Stockfleth E, Gutzmer R, Meier F
J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:38-43. doi: 10.1111/jdv.16024. PMID: 31833610

Diagnosis

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Dyskeratosis congenita and squamous cell carcinoma of the mandibular alveolar ridge.
Manfuso A, Risitano AM, Copelli C
BMJ Case Rep 2021 May 11;14(5) doi: 10.1136/bcr-2021-242459. PMID: 33975847Free PMC Article
Primary squamous cell carcinoma, breast: A challenging diagnosis.
Goel D, Rana C, Babu S, Ramakant P
Cancer Rep (Hoboken) 2021 Oct;4(5):e1391. Epub 2021 May 5 doi: 10.1002/cnr2.1391. PMID: 33951352Free PMC Article
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Ocular sebaceous gland carcinoma: an update of the literature.
Cicinelli MV, Kaliki S
Int Ophthalmol 2019 May;39(5):1187-1197. Epub 2018 Apr 25 doi: 10.1007/s10792-018-0925-z. PMID: 29696467

Therapy

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
The Landmark Series: Non-melanoma Skin Cancers.
Lee AY, Berman RS
Ann Surg Oncol 2020 Jan;27(1):22-27. Epub 2019 Sep 23 doi: 10.1245/s10434-019-07831-9. PMID: 31549317
Medical treatment of advanced cutaneous squamous-cell carcinoma.
Gellrich FF, Hüning S, Beissert S, Eigentler T, Stockfleth E, Gutzmer R, Meier F
J Eur Acad Dermatol Venereol 2019 Dec;33 Suppl 8:38-43. doi: 10.1111/jdv.16024. PMID: 31833610

Prognosis

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Adjuvant therapy for high-risk cutaneous squamous cell carcinoma: 10-year review.
Newman JG, Hall MA, Kurley SJ, Cook RW, Farberg AS, Geiger JL, Koyfman SA
Head Neck 2021 Sep;43(9):2822-2843. Epub 2021 Jun 7 doi: 10.1002/hed.26767. PMID: 34096664Free PMC Article
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Update of the Management of Cutaneous Squamous-cell Carcinoma.
Maubec E
Acta Derm Venereol 2020 Jun 3;100(11):adv00143. doi: 10.2340/00015555-3498. PMID: 32346744Free PMC Article
High-risk cutaneous squamous cell carcinoma.
Nuño-González A, Vicente-Martín FJ, Pinedo-Moraleda F, López-Estebaranz JL
Actas Dermosifiliogr 2012 Sep;103(7):567-78. Epub 2012 Jan 17 doi: 10.1016/j.ad.2011.09.005. PMID: 22261673

Clinical prediction guides

Neoadjuvant cemiplimab and surgery for stage II-IV cutaneous squamous-cell carcinoma: follow-up and survival outcomes of a single-arm, multicentre, phase 2 study.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.
Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Redefining Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma.
Cohen ER, Misztal C, Dable C, Gomez-Fernandez C, Bhatia RG, Roth P, Ma R, Trosman S, Green C, Nicolli E, Dinh CT, Sargi ZB
Otolaryngol Head Neck Surg 2022 Oct;167(4):705-715. Epub 2022 Feb 8 doi: 10.1177/01945998221076110. PMID: 35133896
Management of elderly patients with advanced cutaneous squamous cell carcinoma.
Maeda T, Yoshino K
Jpn J Clin Oncol 2022 Mar 3;52(3):214-220. doi: 10.1093/jjco/hyab213. PMID: 35088087
Squamous Cell Carcinoma and Its Variants.
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225

Recent systematic reviews

Efficacy of micrographic surgery versus conventional excision in reducing recurrence for basal cell carcinoma and squamous cell carcinoma: A systematic review and meta-analysis.
Lacerda PN, Lange EP, Luna NM, Miot HA, Abbade LPF
J Eur Acad Dermatol Venereol 2024 Jun;38(6):1058-1069. Epub 2023 Dec 20 doi: 10.1111/jdv.19743. PMID: 38116955
Electrochemotherapy vs radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies: A systematic review and narrative synthesis.
McMillan AT, McElroy L, O'Toole L, Matteucci P, Totty JP
PLoS One 2023;18(7):e0288251. Epub 2023 Jul 13 doi: 10.1371/journal.pone.0288251. PMID: 37440502Free PMC Article
Adjuvant radiotherapy may not significantly change outcomes in high-risk cutaneous squamous cell carcinomas with clear surgical margins: A systematic review and meta-analysis.
Kim Y, Lehrer EJ, Wirth PJ, Khesroh EA, Brewer JD, Billingsley EM, Zaorsky NG, Lam C
J Am Acad Dermatol 2022 Jun;86(6):1246-1257. Epub 2021 Dec 7 doi: 10.1016/j.jaad.2021.11.059. PMID: 34890701
Outcome following local excision of T1 anal cancers-a systematic review.
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458

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