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Recurrent Lung Non-Small Cell Squamous Carcinoma

MedGen UID:
1750219
•Concept ID:
C5419073
•
Neoplastic Process

Definition

The reemergence of lung squamous non-small cell carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Lung Non-Small Cell Squamous Carcinoma

Professional guidelines

PubMed

A potential treatment option for advanced non-small cell lung cancer: Three cases.
Lee S, Park S, Lee HY, Jeon H, Lee S, Choi S, Eo W
Explore (NY) 2023 May-Jun;19(3):453-457. Epub 2022 Apr 5 doi: 10.1016/j.explore.2022.04.001. PMID: 35431108
Pemetrexed in the treatment of advanced non-squamous lung cancer.
Rossi A, Ricciardi S, Maione P, de Marinis F, Gridelli C
Lung Cancer 2009 Nov;66(2):141-9. Epub 2009 Jul 4 doi: 10.1016/j.lungcan.2009.06.006. PMID: 19577816
Systemic treatment of advanced non-small cell lung cancer.
Traynor AM, Schiller JH
Drugs Today (Barc) 2004 Aug;40(8):697-710. doi: 10.1358/dot.2004.40.8.850472. PMID: 15510241

Recent clinical studies

Etiology

Segmentectomy for clinically early-stage primary squamous cell carcinoma of the lung.
Kagimoto A, Tsutani Y, Shimada Y, Mimae T, Miyata Y, Ito H, Nakayama H, Ikeda N, Okada M
Thorac Cancer 2022 Dec;13(24):3477-3485. Epub 2022 Nov 8 doi: 10.1111/1759-7714.14707. PMID: 36346136Free PMC Article
Prognostic impact of tumor-infiltrating lymphocytes in non-small cell lung carcinomas.
Mlika M, Saidi A, Mejri N, Abdennadher M, Haddouchi C, Labidi S, Khiari H, Boussen H, Hsairi M, Mezni F
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):177-184. Epub 2021 Sep 24 doi: 10.1177/02184923211042129. PMID: 34558296
Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy.
Matsubara T, Hirai F, Yamaguchi M, Hamatake M
Anticancer Res 2021 Oct;41(10):5157-5163. doi: 10.21873/anticanres.15333. PMID: 34593467
PD-L1 Expression in Non-Small-Cell Lung Cancer Including Various Adenocarcinoma Subtypes.
Miyazawa T, Marushima H, Saji H, Kojima K, Hoshikawa M, Takagi M, Nakamura H
Ann Thorac Cardiovasc Surg 2019 Feb 20;25(1):1-9. Epub 2018 Oct 3 doi: 10.5761/atcs.oa.18-00163. PMID: 30282880Free PMC Article
Surgical treatment in non-small cell lung cancer with pulmonary oligometastasis.
He J, Li Y, An J, Hu L, Zhang J
World J Surg Oncol 2017 Feb 2;15(1):36. doi: 10.1186/s12957-017-1105-8. PMID: 28148271Free PMC Article

Diagnosis

Biomarker Testing in Patients With Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer.
Sakamoto T, Matsubara T, Takahama T, Yokoyama T, Nakamura A, Tokito T, Okamoto T, Akamatsu H, Oki M, Sato Y, Tobino K, Ikeda S, Mori M, Mimura C, Maeno K, Miura S, Harada T, Nishimura K, Hiraoka M, Kenmotsu H, Fujimoto J, Shimokawa M, Yamamoto N, Nakagawa K
JAMA Netw Open 2023 Dec 1;6(12):e2347700. doi: 10.1001/jamanetworkopen.2023.47700. PMID: 38100106Free PMC Article
Immunologically active phenotype by gene expression profiling is associated with clinical benefit from PD-1/PD-L1 inhibitors in real-world head and neck and lung cancer patients.
Foy JP, Karabajakian A, Ortiz-Cuaran S, Boussageon M, Michon L, Bouaoud J, Fekiri D, Robert M, Baffert KA, Hervé G, Quilhot P, Attignon V, Girod A, Chaine A, Benassarou M, Zrounba P, Caux C, Ghiringhelli F, Lantuejoul S, Crozes C, Brochériou I, Pérol M, Fayette J, Bertolus C, Saintigny P
Eur J Cancer 2022 Oct;174:287-298. Epub 2022 Aug 26 doi: 10.1016/j.ejca.2022.06.034. PMID: 36038492
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
Biomarker-driven therapies for previously treated squamous non-small-cell lung cancer (Lung-MAP SWOG S1400): a biomarker-driven master protocol.
Redman MW, Papadimitrakopoulou VA, Minichiello K, Hirsch FR, Mack PC, Schwartz LH, Vokes E, Ramalingam S, Leighl N, Bradley J, Miao J, Moon J, Highleyman L, Miwa C, LeBlanc ML, Malik S, Miller VA, Sigal EV, Adam S, Wholley D, Sigman C, Smolich B, Blanke CD, Kelly K, Gandara DR, Herbst RS
Lancet Oncol 2020 Dec;21(12):1589-1601. Epub 2020 Oct 27 doi: 10.1016/S1470-2045(20)30475-7. PMID: 33125909Free PMC Article
Carcinoembryonic antigen (CEA) as tumor marker in lung cancer.
Grunnet M, Sorensen JB
Lung Cancer 2012 May;76(2):138-43. Epub 2011 Dec 6 doi: 10.1016/j.lungcan.2011.11.012. PMID: 22153832

Therapy

MYL-1402O: A Bevacizumab Biosimilar.
Lee A
Target Oncol 2022 Jan;17(1):85-88. Epub 2021 Dec 15 doi: 10.1007/s11523-021-00858-7. PMID: 34910269Free PMC Article
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753).
Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA
Clin Lung Cancer 2021 May;22(3):170-177. Epub 2020 Oct 14 doi: 10.1016/j.cllc.2020.09.013. PMID: 33221175Free PMC Article
Biomarker-driven therapies for previously treated squamous non-small-cell lung cancer (Lung-MAP SWOG S1400): a biomarker-driven master protocol.
Redman MW, Papadimitrakopoulou VA, Minichiello K, Hirsch FR, Mack PC, Schwartz LH, Vokes E, Ramalingam S, Leighl N, Bradley J, Miao J, Moon J, Highleyman L, Miwa C, LeBlanc ML, Malik S, Miller VA, Sigal EV, Adam S, Wholley D, Sigman C, Smolich B, Blanke CD, Kelly K, Gandara DR, Herbst RS
Lancet Oncol 2020 Dec;21(12):1589-1601. Epub 2020 Oct 27 doi: 10.1016/S1470-2045(20)30475-7. PMID: 33125909Free PMC Article
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH
N Engl J Med 2006 Dec 14;355(24):2542-50. doi: 10.1056/NEJMoa061884. PMID: 17167137

Prognosis

Segmentectomy for clinically early-stage primary squamous cell carcinoma of the lung.
Kagimoto A, Tsutani Y, Shimada Y, Mimae T, Miyata Y, Ito H, Nakayama H, Ikeda N, Okada M
Thorac Cancer 2022 Dec;13(24):3477-3485. Epub 2022 Nov 8 doi: 10.1111/1759-7714.14707. PMID: 36346136Free PMC Article
Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy.
Matsubara T, Hirai F, Yamaguchi M, Hamatake M
Anticancer Res 2021 Oct;41(10):5157-5163. doi: 10.21873/anticanres.15333. PMID: 34593467
Surgical treatment in non-small cell lung cancer with pulmonary oligometastasis.
He J, Li Y, An J, Hu L, Zhang J
World J Surg Oncol 2017 Feb 2;15(1):36. doi: 10.1186/s12957-017-1105-8. PMID: 28148271Free PMC Article
Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study.
Hellmann MD, Rizvi NA, Goldman JW, Gettinger SN, Borghaei H, Brahmer JR, Ready NE, Gerber DE, Chow LQ, Juergens RA, Shepherd FA, Laurie SA, Geese WJ, Agrawal S, Young TC, Li X, Antonia SJ
Lancet Oncol 2017 Jan;18(1):31-41. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30624-6. PMID: 27932067Free PMC Article
Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial.
Planchard D, Besse B, Groen HJM, Souquet PJ, Quoix E, Baik CS, Barlesi F, Kim TM, Mazieres J, Novello S, Rigas JR, Upalawanna A, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2016 Jul;17(7):984-993. Epub 2016 Jun 6 doi: 10.1016/S1470-2045(16)30146-2. PMID: 27283860Free PMC Article

Clinical prediction guides

Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma.
Parker AL, Bowman E, Zingone A, Ryan BM, Cooper WA, Kohonen-Corish M, Harris CC, Cox TR
Genome Med 2022 Nov 21;14(1):126. doi: 10.1186/s13073-022-01127-6. PMID: 36404344Free PMC Article
Immunologically active phenotype by gene expression profiling is associated with clinical benefit from PD-1/PD-L1 inhibitors in real-world head and neck and lung cancer patients.
Foy JP, Karabajakian A, Ortiz-Cuaran S, Boussageon M, Michon L, Bouaoud J, Fekiri D, Robert M, Baffert KA, Hervé G, Quilhot P, Attignon V, Girod A, Chaine A, Benassarou M, Zrounba P, Caux C, Ghiringhelli F, Lantuejoul S, Crozes C, Brochériou I, Pérol M, Fayette J, Bertolus C, Saintigny P
Eur J Cancer 2022 Oct;174:287-298. Epub 2022 Aug 26 doi: 10.1016/j.ejca.2022.06.034. PMID: 36038492
A Phase II Study of Telisotuzumab Vedotin in Patients With c-MET-positive Stage IV or Recurrent Squamous Cell Lung Cancer (LUNG-MAP Sub-study S1400K, NCT03574753).
Waqar SN, Redman MW, Arnold SM, Hirsch FR, Mack PC, Schwartz LH, Gandara DR, Stinchcombe TE, Leighl NB, Ramalingam SS, Tanna SH, Raddin RS, Minichiello K, Bradley JD, Kelly K, Herbst RS, Papadimitrakopoulou VA
Clin Lung Cancer 2021 May;22(3):170-177. Epub 2020 Oct 14 doi: 10.1016/j.cllc.2020.09.013. PMID: 33221175Free PMC Article
Biomarker-driven therapies for previously treated squamous non-small-cell lung cancer (Lung-MAP SWOG S1400): a biomarker-driven master protocol.
Redman MW, Papadimitrakopoulou VA, Minichiello K, Hirsch FR, Mack PC, Schwartz LH, Vokes E, Ramalingam S, Leighl N, Bradley J, Miao J, Moon J, Highleyman L, Miwa C, LeBlanc ML, Malik S, Miller VA, Sigal EV, Adam S, Wholley D, Sigman C, Smolich B, Blanke CD, Kelly K, Gandara DR, Herbst RS
Lancet Oncol 2020 Dec;21(12):1589-1601. Epub 2020 Oct 27 doi: 10.1016/S1470-2045(20)30475-7. PMID: 33125909Free PMC Article
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer.
Lu CS, Shiau AL, Su BH, Hsu TS, Wang CT, Su YC, Tsai MS, Feng YH, Tseng YL, Yen YT, Wu CL, Shieh GS
J Hematol Oncol 2020 Jun 1;13(1):62. doi: 10.1186/s13045-020-00887-1. PMID: 32487125Free PMC Article

Recent systematic reviews

Impact of bone metastasis on the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.
Liu L, Shi Z, Qiu X
Clin Transl Oncol 2024 Mar;26(3):747-755. Epub 2023 Aug 11 doi: 10.1007/s12094-023-03300-8. PMID: 37566344
Predictive Role of Tumor-Stroma Ratio for Survival of Patients With Non-Small Cell Lung Cancer: A Meta-Analysis.
Zhang X, Ma H, Zhang L, Li F
Pathol Oncol Res 2021;27:1610021. Epub 2022 Jan 21 doi: 10.3389/pore.2021.1610021. PMID: 35132307Free PMC Article
Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Chen D, Mao Y, Wen J, She Y, Zhu E, Zhu F, Zhang Y, Fan M, Chen C, Chen Y
Ann Thorac Surg 2019 Sep;108(3):945-954. Epub 2019 Mar 23 doi: 10.1016/j.athoracsur.2019.02.045. PMID: 30914285
Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.
Zhang Q, Wang Q, Sun W, Gao F, Liu L, Cheng L, Li Z
Biomed Res Int 2018;2018:6124927. Epub 2018 Nov 25 doi: 10.1155/2018/6124927. PMID: 30596096Free PMC Article
Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies.
Tang H, Wang S, Xiao G, Schiller J, Papadimitrakopoulou V, Minna J, Wistuba II, Xie Y
Ann Oncol 2017 Apr 1;28(4):733-740. doi: 10.1093/annonc/mdw683. PMID: 28200038Free PMC Article

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