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Head and Neck NUT Carcinoma

MedGen UID:
1756150
•Concept ID:
C5420031
•
Neoplastic Process

Definition

A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck NUT Carcinoma

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment.
French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654

Recent clinical studies

Etiology

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma.
Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A
Med Sci (Basel) 2023 Jun 13;11(2) doi: 10.3390/medsci11020042. PMID: 37367741Free PMC Article
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review.
Lee T, Cho J, Baek CH, Son YI, Jeong HS, Chung MK, Hong SD, Ahn YC, Oh DR, Noh JM, Park K, Ahn MJ, Kim HJ, Kim YK, Ko YH
Head Neck 2020 May;42(5):924-938. Epub 2020 Jan 6 doi: 10.1002/hed.26067. PMID: 31903701

Diagnosis

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma.
Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A
Med Sci (Basel) 2023 Jun 13;11(2) doi: 10.3390/medsci11020042. PMID: 37367741Free PMC Article
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article

Therapy

Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations.
Lemelle L, Flaadt T, Fresneau B, Moya-Plana A, Timmermann B, Roganovic J, Ferrari A, Fichera G, Lauer UM, Ben-Ami T, Schneider DT, Vokuhl C, Bolle S, Fox E, DuBois SG, Rodriguez-Galindo C, Bisogno G, Surun A, Brecht IB, Orbach D
J Pediatr Hematol Oncol 2023 May 1;45(4):165-173. Epub 2022 Oct 10 doi: 10.1097/MPH.0000000000002568. PMID: 36219702
Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer.
Chuang HC, Tsai MH, Lin YT, Chou MH, Yang KL, Chien CY
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221146870. doi: 10.1177/15330338221146870. PMID: 36575633Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Prognosis

Nuclear protein of the testis midline carcinoma of the thorax.
Saiki A, Sakamoto K, Bee Y, Izumo T
Jpn J Clin Oncol 2022 May 31;52(6):531-538. doi: 10.1093/jjco/hyac033. PMID: 35325167Free PMC Article
Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway.
Wang J, Jiang C, Li N, Wang F, Xu Y, Shen Z, Yang L, Li Z, He C
Cell Death Dis 2020 Aug 12;11(8):682. doi: 10.1038/s41419-020-02851-w. PMID: 32826876Free PMC Article
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360

Clinical prediction guides

Prediction of Prognosis of Tongue Squamous Cell Carcinoma Based on Clinical MR Imaging Data Modeling.
Liu J, Song L, Zhou J, Yu M, Hu Y, Zhang J, Song P, Ye Y, Wang J, Feng G, Guo H, An P
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207006. doi: 10.1177/15330338231207006. PMID: 37872687Free PMC Article
Molecular Signature of Long Non-Coding RNA Associated with Areca Nut-Induced Head and Neck Cancer.
Huang HH, You GR, Tang SJ, Chang JT, Cheng AJ
Cells 2023 Mar 11;12(6) doi: 10.3390/cells12060873. PMID: 36980216Free PMC Article
Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study.
Jung M, Kim S, Lee JK, Yoon SO, Park HS, Hong SW, Park WS, Kim JE, Kim J, Keam B, Kim HJ, Kang HJ, Kim DW, Jung KC, Kim YT, Heo DS, Kim TM, Jeon YK
Oncologist 2019 Aug;24(8):e740-e748. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0477. PMID: 30696721Free PMC Article
Targeting the DNA Damage Response in OSCC with TP53 Mutations.
Lindemann A, Takahashi H, Patel AA, Osman AA, Myers JN
J Dent Res 2018 Jun;97(6):635-644. Epub 2018 Feb 28 doi: 10.1177/0022034518759068. PMID: 29489434Free PMC Article
NUT carcinoma in children and adults: A multicenter retrospective study.
Lemelle L, Pierron G, Fréneaux P, Huybrechts S, Spiegel A, Plantaz D, Julieron M, Dumoucel S, Italiano A, Millot F, Le Tourneau C, Leverger G, Chastagner P, Carton M, Orbach D
Pediatr Blood Cancer 2017 Dec;64(12) Epub 2017 Jun 23 doi: 10.1002/pbc.26693. PMID: 28643357

Recent systematic reviews

Sinonasal NUT carcinoma: A consecutive case series and systematic review.
Ramesh U, Contrera KJ, Shakibai N, Su SY, Brahimaj B, Roberts D, Williams MD, Ferrarotto R, Phan J, Gunn GB, Raza S, DeMonte F, Hanna EY
Head Neck 2024 Jan;46(1):29-36. Epub 2023 Oct 18 doi: 10.1002/hed.27553. PMID: 37853958
NUT carcinoma of the mandible in a child: case report and systematic review.
Jimenez C, Stanton E, Kondra K, Nickels EM, Jacob L, Shah R, Hammoudeh JA
Int J Oral Maxillofac Surg 2023 Mar;52(3):304-312. Epub 2022 Jul 19 doi: 10.1016/j.ijom.2022.07.002. PMID: 35868909
Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
Head Neck Pathol 2021 Mar;15(1):236-243. Epub 2020 Feb 19 doi: 10.1007/s12105-020-01141-3. PMID: 32077054Free PMC Article
Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases.
Giridhar P, Mallick S, Kashyap L, Rath GK
Eur Arch Otorhinolaryngol 2018 Mar;275(3):815-821. Epub 2018 Jan 22 doi: 10.1007/s00405-018-4882-y. PMID: 29356890

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