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Sinonasal NUT Carcinoma

MedGen UID:
1768085
•Concept ID:
C5420032
•
Neoplastic Process
Synonym: Nasal Cavity and Paranasal Sinus NUT Carcinoma

Definition

A highly aggressive, poorly differentiated carcinoma that arises from the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal NUT Carcinoma

Professional guidelines

PubMed

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435

Recent clinical studies

Etiology

Sinonasal NUT carcinoma: A consecutive case series and systematic review.
Ramesh U, Contrera KJ, Shakibai N, Su SY, Brahimaj B, Roberts D, Williams MD, Ferrarotto R, Phan J, Gunn GB, Raza S, DeMonte F, Hanna EY
Head Neck 2024 Jan;46(1):29-36. Epub 2023 Oct 18 doi: 10.1002/hed.27553. PMID: 37853958

Diagnosis

Sinonasal NUT Carcinoma: Delayed Diagnosis Due to the COVID-19 Pandemic and a Review of the Literature.
Crocetta FM, Botti C, Fornaciari M, Castellucci A, Murri D, Santandrea G, Piana S, Ghidini A
Head Neck Pathol 2021 Dec;15(4):1409-1414. Epub 2021 Mar 8 doi: 10.1007/s12105-021-01311-x. PMID: 33686584Free PMC Article
Sinonasal NUT carcinoma: clinicopathological and cytogenetic analysis with autopsy findings.
Minato H, Kobayashi E, Nakada S, Kurose N, Tanaka M, Tanaka Y, Suzuki S, Tanioka F, Saikawa Y, Miwa T, Nojima T
Hum Pathol 2018 Jan;71:157-165. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.011. PMID: 29079177

Prognosis

Sinonasal NUT Carcinoma: Delayed Diagnosis Due to the COVID-19 Pandemic and a Review of the Literature.
Crocetta FM, Botti C, Fornaciari M, Castellucci A, Murri D, Santandrea G, Piana S, Ghidini A
Head Neck Pathol 2021 Dec;15(4):1409-1414. Epub 2021 Mar 8 doi: 10.1007/s12105-021-01311-x. PMID: 33686584Free PMC Article

Recent systematic reviews

Sinonasal NUT carcinoma: A consecutive case series and systematic review.
Ramesh U, Contrera KJ, Shakibai N, Su SY, Brahimaj B, Roberts D, Williams MD, Ferrarotto R, Phan J, Gunn GB, Raza S, DeMonte F, Hanna EY
Head Neck 2024 Jan;46(1):29-36. Epub 2023 Oct 18 doi: 10.1002/hed.27553. PMID: 37853958

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